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Protein

Poly [ADP-ribose] polymerase 14

Gene

Parp14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has ADP-ribosyltransferase activity (By similarity). Enhances STAT6-dependent transcription.By similarity1 Publication

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 14 (EC:2.4.2.30)
Short name:
PARP-14
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 8
Short name:
ARTD8
Collaborator of STAT6
Short name:
CoaSt6
Gene namesi
Name:Parp14
Synonyms:Kiaa1268
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1919489. Parp14.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18171817Poly [ADP-ribose] polymerase 14PRO_0000247590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331PhosphoserineBy similarity
Modified residuei1419 – 14191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ2EMV9.
MaxQBiQ2EMV9.
PaxDbiQ2EMV9.
PeptideAtlasiQ2EMV9.
PRIDEiQ2EMV9.

PTM databases

iPTMnetiQ2EMV9.
PhosphoSiteiQ2EMV9.

Expressioni

Tissue specificityi

Weakly expressed in the thymus during development and in adulthood.1 Publication

Gene expression databases

BgeeiENSMUSG00000034422.
CleanExiMM_PARP14.
GenevisibleiQ2EMV9. MM.

Interactioni

Subunit structurei

Interacts with STAT6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GpiP067454EBI-1534943,EBI-1534927

Protein-protein interaction databases

BioGridi246104. 2 interactions.
DIPiDIP-38053N.
IntActiQ2EMV9. 2 interactions.
STRINGi10090.ENSMUSP00000037657.

Structurei

Secondary structure

1
1817
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1532 – 15343Combined sources
Turni1537 – 15415Combined sources
Helixi1542 – 15487Combined sources
Beta strandi1552 – 15565Combined sources
Beta strandi1561 – 15633Combined sources
Helixi1568 – 157710Combined sources
Beta strandi1581 – 15877Combined sources
Beta strandi1590 – 15956Combined sources
Turni1596 – 15994Combined sources
Beta strandi1600 – 16023Combined sources
Beta strandi1608 – 16147Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4RNMR-A1532-1617[»]
ProteinModelPortaliQ2EMV9.
SMRiQ2EMV9. Positions 802-1203, 1220-1399, 1534-1617, 1635-1817.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2EMV9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini802 – 989188Macro 1PROSITE-ProRule annotationAdd
BLAST
Domaini1014 – 1202189Macro 2PROSITE-ProRule annotationAdd
BLAST
Domaini1227 – 1398172Macro 3PROSITE-ProRule annotationAdd
BLAST
Domaini1539 – 161779WWEPROSITE-ProRule annotationAdd
BLAST
Domaini1621 – 1817197PARP catalyticPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi771 – 80030Glu-richAdd
BLAST

Sequence similaritiesi

Contains 3 Macro domains.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
Contains 1 WWE domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000168887.
HOVERGENiHBG082105.
InParanoidiQ2EMV9.
KOiK15261.
OMAiRRCHCEL.
OrthoDBiEOG091G00EB.
TreeFamiTF328965.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR002589. Macro_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
[Graphical view]
PfamiPF01661. Macro. 3 hits.
PF00644. PARP. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 3 hits.
[Graphical view]
PROSITEiPS51154. MACRO. 3 hits.
PS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2EMV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASGSFPLL VEGSWGPDPP KNLINKLQVY FQSRKKSGGG ECEVVPEPGN
60 70 80 90 100
PARFRVLFSP EDVRQNVLER GNHELVWQEK GTFKLTVLMP TDPEEASASK
110 120 130 140 150
KSRKESPEEE SKTKEDAVKQ GDLDITHSPS SGSEKTEDVP KECENISSMV
160 170 180 190 200
AFENLPEKVS EMVLTILVEN ISGLPSDDFK VEVNRDFAVA VVTFQKPIDI
210 220 230 240 250
KKFIVDCISH RSNQQLQLAP RLLETTNVVR VENLPPGVDE YQLQLFFENP
260 270 280 290 300
FNGGGRVARV ECFPEESSAL VEFCDSKVLD TVMAKTHSYN KMPLSVFPYY
310 320 330 340 350
PSLGTALYGE EKPLIKLPAS FQESLDLPLW KFFQKNNHLI EEINNEMRCC
360 370 380 390 400
HCELTWSEIN GKLTIRPAAT LVNHRLSIKT WQRDASAVLS GIKSKYGVEL
410 420 430 440 450
FEVCSPVWDI IKHELESGDD RVLVEFEKES LNIAGKSEDV QGMSQKIREL
460 470 480 490 500
IESTTEKLRR EEQSLKEKVA ISPGKHYLLH HSGFLKDLSK GFPEMEISYD
510 520 530 540 550
ATAQFLYLKG FRADVYKVKC DIQEKVFSMA QKDVQVSSEV FEFLQQVDSQ
560 570 580 590 600
RLSKSLFEAQ NILAIYELKG TALFLVGSSF KDLAEAETKM LSALSHKQIE
610 620 630 640 650
VEDKEVLISN GWKKKVHPLQ KRHSSCATII VQNELTSETP AKVIVTGCVK
660 670 680 690 700
EVNEIHRQLF EYLENNMKVE RALKIKPSLI VDYLRTDKRL LSKIKKAHVY
710 720 730 740 750
VHFKPKDNPN SILLTGCKSK VLECMNLVKE IQDSVCVQRF QTDKAGVRHF
760 770 780 790 800
FKDKESYYKT EIGRQFGCVI ELEEDREEKG EEEDGEEEEG EEEGESSINE
810 820 830 840 850
QKCHLQRDIA PGVKLFVLEE DLSRFPVDVV VNAANENLKH ISGLAQALSK
860 870 880 890 900
AAGPELQTEC DQIVKEGGVV LPGNAVISKA GKLPCHHVIH AVGPRWKGDK
910 920 930 940 950
VLECVSLLKK VVRQSLSLAE EHRCRSIAMP AVSAGIFDFP LELCVANIVS
960 970 980 990 1000
AIKEHFQHKR DTHTLKKIYL VGLPAKVARA FAEAVKTTYK DSLSHTAFPS
1010 1020 1030 1040 1050
SLKALVPLGK TPQKQGSLLV SPEGLRIRLV EEGVQNATTH AIVNSISPDL
1060 1070 1080 1090 1100
KLNKGPLSQA FLEKAGPKLQ EELTRSGQGV SVDVGTILQT SGCNLNSRHV
1110 1120 1130 1140 1150
FHVVPPPWKS NNSAWSLKIM KNIIRDCLKT TENLSLQSIA FPAIGTGNLR
1160 1170 1180 1190 1200
FPKPEFAKLI ISEVLKFSSR NQLKTLQEVQ FLLHPKDHEN IQAFSDEFDK
1210 1220 1230 1240 1250
RNNGDPSDKN PKAEDTQGIY GSLSSPTLGM HEMNIGPILF QVATGNIIKE
1260 1270 1280 1290 1300
VADVIVNSTT LTFDLKSGVS KAILEGAGQN VEQECSLLAK QSNHGYIVTG
1310 1320 1330 1340 1350
GGLLQCKNII HVVGGNDVKK SVSCVLEECE QRNYSSICLP AIGTGNAQQD
1360 1370 1380 1390 1400
PNVVAKAIID AIEEFVQKKS VQAVKRVKVV IFQPHILQFF YDNMKEREGS
1410 1420 1430 1440 1450
PAPPKQSPAK QSVMSKIASF LGFPKQASPK KNTLVLEKKI EHTVFQVCGS
1460 1470 1480 1490 1500
GVDSVNKTIS WLKELITKEQ LSYTNDDECV SDFDMEEYEK LNEIQKELNI
1510 1520 1530 1540 1550
TIEMNQKKTS IQVSGISRDV IKARDEIEGM IKSIRLAKEK ESQADYISTY
1560 1570 1580 1590 1600
VEWQYIDKNI TQCFDKMTNM KLEVAWKAKK KDTVVQIHNQ DFTVDLSTNT
1610 1620 1630 1640 1650
ATAPQGQTFT VQRLVKAEAE IPANWSDMKQ DKLLLVNLQT SDPEYNMVAS
1660 1670 1680 1690 1700
AFRQTCSNFF IEKIERIQNP ALWRRYQAYK KSMDEKNGNV RNEKHLFHGT
1710 1720 1730 1740 1750
EASSLPQLNS NGFNRSYAGK NATAYGKGTY FAVKASYSAC DTYSRPDTNG
1760 1770 1780 1790 1800
RKYMYYVRVL TGNYTNGNAS LIVPPSRDPQ NAADLYDTVT DNDKNPSIFV
1810
VFYDNQTYPE YLITFRQ
Length:1,817
Mass (Da):203,802
Last modified:July 27, 2011 - v3
Checksum:i42E902CC20858931
GO
Isoform 2 (identifier: Q2EMV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-589: Missing.

Show »
Length:1,228
Mass (Da):137,366
Checksum:i3E066E6F69CD4193
GO

Sequence cautioni

The sequence AAH21340 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH21340 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti708 – 7081N → Y in ABD16173 (PubMed:16537510).Curated
Sequence conflicti789 – 7891E → K in BAC40943 (PubMed:16141072).Curated
Sequence conflicti1045 – 10451S → T in ABD16173 (PubMed:16537510).Curated
Sequence conflicti1209 – 12091K → E in BAC40943 (PubMed:16141072).Curated
Sequence conflicti1609 – 16091F → L in ABD16173 (PubMed:16537510).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1384 – 13841P → S in strain: Czech II. 1 Publication
Natural varianti1658 – 16581N → D in strain: Czech II. 1 Publication
Natural varianti1682 – 16821S → G in strain: Czech II. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 589589Missing in isoform 2. 1 PublicationVSP_020020Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ372930 mRNA. Translation: ABD16173.1.
AC129574 Genomic DNA. No translation available.
AK089685 mRNA. Translation: BAC40943.1.
AK220263 mRNA. Translation: BAD90188.1.
BC021340 mRNA. Translation: AAH21340.1. Different initiation.
CCDSiCCDS28143.1. [Q2EMV9-1]
RefSeqiNP_001034619.2. NM_001039530.3. [Q2EMV9-1]
UniGeneiMm.244406.

Genome annotation databases

EnsembliENSMUST00000042665; ENSMUSP00000037657; ENSMUSG00000034422. [Q2EMV9-1]
GeneIDi547253.
KEGGimmu:547253.
UCSCiuc007zbs.2. mouse. [Q2EMV9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ372930 mRNA. Translation: ABD16173.1.
AC129574 Genomic DNA. No translation available.
AK089685 mRNA. Translation: BAC40943.1.
AK220263 mRNA. Translation: BAD90188.1.
BC021340 mRNA. Translation: AAH21340.1. Different initiation.
CCDSiCCDS28143.1. [Q2EMV9-1]
RefSeqiNP_001034619.2. NM_001039530.3. [Q2EMV9-1]
UniGeneiMm.244406.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4RNMR-A1532-1617[»]
ProteinModelPortaliQ2EMV9.
SMRiQ2EMV9. Positions 802-1203, 1220-1399, 1534-1617, 1635-1817.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246104. 2 interactions.
DIPiDIP-38053N.
IntActiQ2EMV9. 2 interactions.
STRINGi10090.ENSMUSP00000037657.

PTM databases

iPTMnetiQ2EMV9.
PhosphoSiteiQ2EMV9.

Proteomic databases

EPDiQ2EMV9.
MaxQBiQ2EMV9.
PaxDbiQ2EMV9.
PeptideAtlasiQ2EMV9.
PRIDEiQ2EMV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042665; ENSMUSP00000037657; ENSMUSG00000034422. [Q2EMV9-1]
GeneIDi547253.
KEGGimmu:547253.
UCSCiuc007zbs.2. mouse. [Q2EMV9-1]

Organism-specific databases

CTDi54625.
MGIiMGI:1919489. Parp14.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000168887.
HOVERGENiHBG082105.
InParanoidiQ2EMV9.
KOiK15261.
OMAiRRCHCEL.
OrthoDBiEOG091G00EB.
TreeFamiTF328965.

Miscellaneous databases

EvolutionaryTraceiQ2EMV9.
PROiQ2EMV9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034422.
CleanExiMM_PARP14.
GenevisibleiQ2EMV9. MM.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR002589. Macro_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
[Graphical view]
PfamiPF01661. Macro. 3 hits.
PF00644. PARP. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 3 hits.
[Graphical view]
PROSITEiPS51154. MACRO. 3 hits.
PS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR14_MOUSE
AccessioniPrimary (citable) accession number: Q2EMV9
Secondary accession number(s): E9QP48
, Q571C6, Q8BN35, Q8VDT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.