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Protein

Polycystic kidney disease protein 1-like 3

Gene

Pkd1l3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.5 Publications

Enzyme regulationi

The calcium channel is gated following an off-response property by acid: gated open after the removal of acid stimulus, but not during acid application.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: BHF-UCL
  • cellular response to acidic pH Source: BHF-UCL
  • detection of chemical stimulus involved in sensory perception of sour taste Source: BHF-UCL
  • detection of mechanical stimulus Source: GO_Central
  • sensory perception of sour taste Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Lectin

Protein family/group databases

MEROPSiP02.041.

Names & Taxonomyi

Protein namesi
Recommended name:
Polycystic kidney disease protein 1-like 3
Alternative name(s):
PC1-like 3 protein
Polycystin-1L3
Gene namesi
Name:Pkd1l3
ORF Names:71B10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2664670. Pkd1l3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 10831059ExtracellularSequence analysisAdd
BLAST
Transmembranei1084 – 110421HelicalSequence analysisAdd
BLAST
Topological domaini1105 – 1293189CytoplasmicSequence analysisAdd
BLAST
Transmembranei1294 – 131421HelicalSequence analysisAdd
BLAST
Topological domaini1315 – 133016ExtracellularSequence analysisAdd
BLAST
Transmembranei1331 – 135121HelicalSequence analysisAdd
BLAST
Topological domaini1352 – 1543192CytoplasmicSequence analysisAdd
BLAST
Transmembranei1544 – 156421HelicalSequence analysisAdd
BLAST
Topological domaini1565 – 158521ExtracellularSequence analysisAdd
BLAST
Transmembranei1586 – 160621HelicalSequence analysisAdd
BLAST
Topological domaini1607 – 166660CytoplasmicSequence analysisAdd
BLAST
Transmembranei1667 – 168721HelicalSequence analysisAdd
BLAST
Topological domaini1688 – 1855168ExtracellularSequence analysisAdd
BLAST
Transmembranei1856 – 187621HelicalSequence analysisAdd
BLAST
Topological domaini1877 – 190226CytoplasmicSequence analysisAdd
BLAST
Transmembranei1903 – 192321HelicalSequence analysisAdd
BLAST
Topological domaini1924 – 194421ExtracellularSequence analysisAdd
BLAST
Transmembranei1945 – 196521HelicalSequence analysisAdd
BLAST
Topological domaini1966 – 203267CytoplasmicSequence analysisAdd
BLAST
Transmembranei2033 – 205321HelicalSequence analysisAdd
BLAST
Topological domaini2054 – 20607ExtracellularSequence analysis
Transmembranei2061 – 207818HelicalSequence analysisAdd
BLAST
Topological domaini2079 – 209820CytoplasmicSequence analysisAdd
BLAST
Transmembranei2099 – 211921HelicalSequence analysisAdd
BLAST
Topological domaini2120 – 220182ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • cation channel complex Source: BHF-UCL
  • extracellular exosome Source: MGI
  • plasma membrane Source: UniProtKB
  • receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No significant reduction in taste responsiveness: mice have normal nerve and behavioral responses to sour stimuli.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2059 – 20591D → N: Little or no effect on calcium channel activity. 1 Publication
Mutagenesisi2082 – 20821E → Q: Little or no effect on calcium channel activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 22012177Polycystic kidney disease protein 1-like 3PRO_0000322579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 141PROSITE-ProRule annotation
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 133PROSITE-ProRule annotation
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence analysis
Glycosylationi579 – 5791N-linked (GlcNAc...)Sequence analysis
Glycosylationi592 – 5921N-linked (GlcNAc...)Sequence analysis
Glycosylationi923 – 9231N-linked (GlcNAc...)Sequence analysis
Glycosylationi961 – 9611N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ2EG98.
PaxDbiQ2EG98.
PRIDEiQ2EG98.

PTM databases

iPTMnetiQ2EG98.
PhosphoSiteiQ2EG98.

Expressioni

Tissue specificityi

Expressed in a subset of taste receptor cells distinct from those involved in bitter, sweet and umami taste. Expressed in circumvallate and foliate taste buds, but not in surrounding non-gustatory lingual epithelium cells. Expressed in testis.3 Publications

Gene expression databases

BgeeiQ2EG98.
CleanExiMM_PKD1L3.
ExpressionAtlasiQ2EG98. baseline and differential.

Interactioni

Subunit structurei

Calcium channels are probably composed of 3 subunit of PKD2L1 and 1 subunit of PKD1L3.

Protein-protein interaction databases

DIPiDIP-61249N.
STRINGi10090.ENSMUSP00000104865.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 142109C-type lectinAdd
BLAST
Domaini1018 – 106750GPSPROSITE-ProRule annotationAdd
BLAST
Domaini1129 – 1246118PLATPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2053 – 209139Channel pore-regionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1744 – 175411Polycystin motifAdd
BLAST
Motifi1840 – 185011Polycystin motifAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi236 – 602367Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the polycystin family.Curated
Contains 1 C-type lectin domain.Curated
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 PLAT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410YE1E. LUCA.
GeneTreeiENSGT00700000104221.
HOVERGENiHBG066396.
InParanoidiQ2EG98.
KOiK04989.
OMAiYIMAVEN.
OrthoDBiEOG7BW0HJ.
TreeFamiTF316484.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000203. GPS.
IPR013122. PKD1_2_channel.
IPR003915. PKD_2.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PfamiPF01825. GPS. 1 hit.
PF08016. PKD_channel. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR01433. POLYCYSTIN2.
SMARTiSM00303. GPS. 1 hit.
SM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50221. GPS. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2EG98-1) [UniParc]FASTAAdd to basket

Also known as: Variant 1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLQRRSWLW LYIRIGVILG DILGRKPSIR EQHGGNSCYQ LNRLFCDFQE
60 70 80 90 100
ADNYCHAQRG RLAHTWNPKL RGFLKSFLNE ETVWWVRGNL TLPGSHPGIN
110 120 130 140 150
QTGGDDVLRN QKPGECPSVV THSNAVFSRW NLCIEKHHFI CQAAAFPPQG
160 170 180 190 200
ASIWRNEFGP GPLLPMKRRG AETERHMIPG NGPPLAMCHQ PAPPELFETL
210 220 230 240 250
CFPIDPASSA PPKATHRMTI TSLTGRPQVT SDTLASSSPP QGTSDTPASS
260 270 280 290 300
SPPQVTSATS ASSSPPQGTS DTPASSSPPQ VTSATSASSS PPQGTSDTPA
310 320 330 340 350
SSSPPQVTSA TSASSSPPQG TSDTPASSSP PQVTSATSAS SSPPQGTSDT
360 370 380 390 400
PASSSPPQGT LDTPSSSSPP QGTSDTPASS SPPQGTSETP ASNSPPQGTS
410 420 430 440 450
ETPGFSSPPQ VTTATLVSSS PPQVTSETPA SSSPTQVTSE TPASSSPTQV
460 470 480 490 500
TSDTPASNSP PQGTSDTPGF SSPTQVTTAT LVSSSPPQVT SDTPASSSPP
510 520 530 540 550
QVTSDTPASS SPPQVTSETP ASSSPPQVTS DTSASISPPQ VISDTPASSS
560 570 580 590 600
PPQVTSETPA SSSPTNMTSD TPASSSPTNM TSDTPASSSP TNMTSDTPAS
610 620 630 640 650
SSPPWPVITE VTRPESTIPA GRSLANITSK AQEDSPLGVI STHPQMSFQS
660 670 680 690 700
STSQALDETA GERVPTIPDF QAHSEFQKAC AILQRLRDFL PTSPTSAQKN
710 720 730 740 750
NSWSSQTPAV SCPFQPLGRL TTTEKSSHQM AQQDMEQHPM DGAHNAFGIS
760 770 780 790 800
AGGSEIQSDI QLRSEFEVED MLETSLMALG EIHRAFCQQS LCPQSAVTLA
810 820 830 840 850
SPSATLMLSS QNVSTLPLST YTLGEPAPLT LGFPSAEALK ELLNKHPGVN
860 870 880 890 900
LQVTGLAFNP FKTLDDKNIV GSIGNVQLSS AYQSIRVHDL IEDIEIMLWR
910 920 930 940 950
NASMETQPTS LNTSTDHFTI SVNITSLEKT LIVTIEPESP LLMTLHLGFQ
960 970 980 990 1000
DQLAHTHFYL NISLPRDQVW QKDEEYTWVL TPENLWYGTG TYYIMAVENK
1010 1020 1030 1040 1050
STEAAQHTPV LVSVVTAVTQ CYFWDRYNRT WKSDGCQVGP KSTILKTQCL
1060 1070 1080 1090 1100
CDHLTFFSSD FFIVPRTVDV ENTIKLLLHV TNNPVGVSLL SSLLGFYILL
1110 1120 1130 1140 1150
AMWASRKDRE DMQKVKVTVL ADNDPSSASH YLIQVYTGYR RRAATTAKVV
1160 1170 1180 1190 1200
ITLYGSEGHS EPHHLCDPEK TVFERGALDV FLLSTGSWLG DLHGLRLWHD
1210 1220 1230 1240 1250
NSGDSPSWYV SQVIVSDMTT RKKWHFQCNC WLAVDLGNCE RDRVFTPASR
1260 1270 1280 1290 1300
SELSSFRHLF SSTIVEKFTQ DYLWLSVATR HPWNQFTRVQ RLSCCMALLL
1310 1320 1330 1340 1350
CDMVINIMFW KMGGTTAKRG TEQLGPLAVT LSELLVSIQT SIILFPIHLI
1360 1370 1380 1390 1400
FGRLFQLIHP PEALPQLPFI QAAWPPALVC ESPSLTQVVK ELKETVGFLL
1410 1420 1430 1440 1450
RRNTQLLSEC EPSSCSSCDI NKLAKLLSGL IYCHLEDEGC HQQTESHWED
1460 1470 1480 1490 1500
AVSENHYHFC RYLLQLLRRL KAHLEALGAT QDHQSCDFSE AVSQLQNLQE
1510 1520 1530 1540 1550
LLETQTLRRG PGPCRHSTSF PILSPGEGKK PMSFCLFRWL KCSCWLLLGV
1560 1570 1580 1590 1600
ISLASAFFIT LYSLELDKDQ ATSWVISMML SVLQDIFISQ PIKVIFLTLL
1610 1620 1630 1640 1650
FSLMANHMPW LNKDKEQHAR RIVALWAKCP WSAPGLRDKN NPIYTAPAMN
1660 1670 1680 1690 1700
NLAKPTRKAW KKQLSKLTGG TLVQILFLTL LMTTVYSAKD SSRFFLHRAI
1710 1720 1730 1740 1750
WKRFSHRFSE IKTVEDFYPW ANGTLLPNLY GDYRGFITDG NSFLLGNVLI
1760 1770 1780 1790 1800
RQTRIPNDIF FPGSLHKQMK SPPQHQEDRE NYGAGWVPPD TNITKVDSIW
1810 1820 1830 1840 1850
HYQNQESLGG YPIQGELATY SGGGYVVRLG RNHSAATRVL QHLEQRRWLD
1860 1870 1880 1890 1900
HCTKALFVEF TVFNANVNLL CAVTLILESS GVGTFLTSLQ LDSLTSLQSS
1910 1920 1930 1940 1950
ERGFAWIVSQ VVYYLLVCYY AFIQGCRLKR QRLAFFTRKR NLLDTSIVLI
1960 1970 1980 1990 2000
SFSILGLSMQ SLSLLHKKMQ QYHCDRDRFI SFYEALRVNS AVTHLRGFLL
2010 2020 2030 2040 2050
LFATVRVWDL LRHHAQLQVI NKTLSKAWDE VLGFILIIVV LLSSYAMTFN
2060 2070 2080 2090 2100
LLFGWSISDY QSFFRSIVTV VGLLMGTSKH KEVIALYPIL GSLLVLSSII
2110 2120 2130 2140 2150
LMGLVIINLF VSAILIAFGK ERKACEKEAT LTDMLLQKLS SLLGIRLHQN
2160 2170 2180 2190 2200
PSEEHADNTG SSNLRERSSK SMSSDAEVLA PADAVGSVSG TDGNSGSTKV

L
Length:2,201
Mass (Da):241,253
Last modified:July 27, 2011 - v2
Checksum:i389C31618FA84C07
GO
Isoform 2 (identifier: Q2EG98-2) [UniParc]FASTAAdd to basket

Also known as: Variant 1b

The sequence of this isoform differs from the canonical sequence as follows:
     698-698: Q → QVSVANLLIDLSEQLLVLPFQ
     738-767: Missing.

Show »
Length:2,191
Mass (Da):240,263
Checksum:i9F312AD58E96BF0B
GO
Isoform 3 (identifier: Q2EG98-3) [UniParc]FASTAAdd to basket

Also known as: Variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     2200-2201: VL → GTRDI

Show »
Length:2,204
Mass (Da):241,584
Checksum:i83BDF05E0681618F
GO
Isoform 4 (identifier: Q2EG98-4) [UniParc]FASTAAdd to basket

Also known as: Variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     2200-2201: VL → IPASTVTKKCKQARHGGACL

Show »
Length:2,219
Mass (Da):243,092
Checksum:iCB7DBD597A8BB930
GO
Isoform 5 (identifier: Q2EG98-5) [UniParc]FASTAAdd to basket

Also known as: Variant 4

The sequence of this isoform differs from the canonical sequence as follows:
     1885-2201: Missing.

Show »
Length:1,884
Mass (Da):205,802
Checksum:i82BCBEDE41DE70A2
GO
Isoform 6 (identifier: Q2EG98-6) [UniParc]FASTAAdd to basket

Also known as: Variant 5

The sequence of this isoform differs from the canonical sequence as follows:
     102-102: T → TDYIL
     698-698: Q → QVSVANLLIDLSEQLLVLPFQ
     738-767: Missing.
     1391-1409: ELKETVGFLLRRNTQLLSE → QCLKTITISAATFSNFCGD
     1410-2201: Missing.

Show »
Length:1,403
Mass (Da):151,051
Checksum:i3B20B74DC2F9CCE1
GO
Isoform 7 (identifier: Q2EG98-7) [UniParc]FASTAAdd to basket

Also known as: Variant 6

The sequence of this isoform differs from the canonical sequence as follows:
     1391-1398: ELKETVGF → VSLVSTVF
     1399-2201: Missing.

Show »
Length:1,398
Mass (Da):150,367
Checksum:i7D76E04DB329C85C
GO
Isoform 8 (identifier: Q2EG98-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-698: Q → QVSVANLLIDLSEQLLVLPFQ
     738-767: Missing.
     2161-2201: SSNLRERSSKSMSSDAEVLAPADAVGSVSGTDGNSGSTKVL → Y

Show »
Length:2,151
Mass (Da):236,389
Checksum:i138B68AC13771378
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti294 – 2941G → V in ABD36563 (PubMed:16805797).Curated
Sequence conflicti308 – 3081T → A in ABD36562 (PubMed:16805797).Curated
Sequence conflicti308 – 3081T → A in ABD36564 (PubMed:16805797).Curated
Sequence conflicti794 – 7941Q → L in ABD36564 (PubMed:16805797).Curated
Sequence conflicti812 – 8121N → K in ABD36564 (PubMed:16805797).Curated
Sequence conflicti822 – 8221T → P in ABD36564 (PubMed:16805797).Curated
Sequence conflicti916 – 9161D → G in ABD36564 (PubMed:16805797).Curated
Sequence conflicti1063 – 10631I → S in AAO32799 (PubMed:12782129).Curated
Sequence conflicti1113 – 11131Q → L in ABD36564 (PubMed:16805797).Curated
Sequence conflicti1130 – 11301H → L in ABD36564 (PubMed:16805797).Curated
Sequence conflicti1341 – 13411S → P in ABD36562 (PubMed:16805797).Curated
Sequence conflicti1538 – 15381R → K in ABD36562 (PubMed:16805797).Curated
Sequence conflicti1618 – 16181H → R in ABD36563 (PubMed:16805797).Curated
Sequence conflicti1618 – 16181H → R in ABD36566 (PubMed:16805797).Curated
Sequence conflicti1618 – 16181H → R in ABD36567 (PubMed:16805797).Curated
Sequence conflicti1618 – 16181H → R in ABD36568 (PubMed:16805797).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei102 – 1021T → TDYIL in isoform 6. 1 PublicationVSP_031952
Alternative sequencei698 – 6981Q → QVSVANLLIDLSEQLLVLPF Q in isoform 2, isoform 6 and isoform 8. 2 PublicationsVSP_031953
Alternative sequencei738 – 76730Missing in isoform 2, isoform 6 and isoform 8. 2 PublicationsVSP_031954Add
BLAST
Alternative sequencei1391 – 140919ELKET…QLLSE → QCLKTITISAATFSNFCGD in isoform 6. 1 PublicationVSP_031955Add
BLAST
Alternative sequencei1391 – 13988ELKETVGF → VSLVSTVF in isoform 7. 1 PublicationVSP_031956
Alternative sequencei1399 – 2201803Missing in isoform 7. 1 PublicationVSP_031957Add
BLAST
Alternative sequencei1410 – 2201792Missing in isoform 6. 1 PublicationVSP_031958Add
BLAST
Alternative sequencei1885 – 2201317Missing in isoform 5. 1 PublicationVSP_031959Add
BLAST
Alternative sequencei2161 – 220141SSNLR…STKVL → Y in isoform 8. 1 PublicationVSP_031960Add
BLAST
Alternative sequencei2200 – 22012VL → GTRDI in isoform 3. 1 PublicationVSP_031961
Alternative sequencei2200 – 22012VL → IPASTVTKKCKQARHGGACL in isoform 4. 1 PublicationVSP_031962

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164486 mRNA. Translation: AAO32799.1.
DQ382344 mRNA. Translation: ABD36562.1.
DQ382345 mRNA. Translation: ABD36563.1.
DQ382346 mRNA. Translation: ABD36564.1.
DQ382347 mRNA. Translation: ABD36565.1.
DQ382348 mRNA. Translation: ABD36566.1.
DQ382349 mRNA. Translation: ABD36567.1.
DQ382350 mRNA. Translation: ABD36568.1.
AC125162 Genomic DNA. No translation available.
CCDSiCCDS22654.1. [Q2EG98-8]
CCDS40472.1. [Q2EG98-1]
RefSeqiNP_001034789.2. NM_001039700.2. [Q2EG98-1]
NP_001273383.1. NM_001286454.1. [Q2EG98-2]
NP_853522.2. NM_181544.2. [Q2EG98-8]
UniGeneiMm.436810.

Genome annotation databases

EnsembliENSMUST00000057344; ENSMUSP00000051512; ENSMUSG00000048827. [Q2EG98-8]
ENSMUST00000109242; ENSMUSP00000104865; ENSMUSG00000048827. [Q2EG98-1]
GeneIDi244646.
KEGGimmu:244646.
UCSCiuc009niu.1. mouse. [Q2EG98-1]
uc009niv.1. mouse. [Q2EG98-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164486 mRNA. Translation: AAO32799.1.
DQ382344 mRNA. Translation: ABD36562.1.
DQ382345 mRNA. Translation: ABD36563.1.
DQ382346 mRNA. Translation: ABD36564.1.
DQ382347 mRNA. Translation: ABD36565.1.
DQ382348 mRNA. Translation: ABD36566.1.
DQ382349 mRNA. Translation: ABD36567.1.
DQ382350 mRNA. Translation: ABD36568.1.
AC125162 Genomic DNA. No translation available.
CCDSiCCDS22654.1. [Q2EG98-8]
CCDS40472.1. [Q2EG98-1]
RefSeqiNP_001034789.2. NM_001039700.2. [Q2EG98-1]
NP_001273383.1. NM_001286454.1. [Q2EG98-2]
NP_853522.2. NM_181544.2. [Q2EG98-8]
UniGeneiMm.436810.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61249N.
STRINGi10090.ENSMUSP00000104865.

Protein family/group databases

MEROPSiP02.041.

PTM databases

iPTMnetiQ2EG98.
PhosphoSiteiQ2EG98.

Proteomic databases

MaxQBiQ2EG98.
PaxDbiQ2EG98.
PRIDEiQ2EG98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057344; ENSMUSP00000051512; ENSMUSG00000048827. [Q2EG98-8]
ENSMUST00000109242; ENSMUSP00000104865; ENSMUSG00000048827. [Q2EG98-1]
GeneIDi244646.
KEGGimmu:244646.
UCSCiuc009niu.1. mouse. [Q2EG98-1]
uc009niv.1. mouse. [Q2EG98-2]

Organism-specific databases

CTDi342372.
MGIiMGI:2664670. Pkd1l3.

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410YE1E. LUCA.
GeneTreeiENSGT00700000104221.
HOVERGENiHBG066396.
InParanoidiQ2EG98.
KOiK04989.
OMAiYIMAVEN.
OrthoDBiEOG7BW0HJ.
TreeFamiTF316484.

Miscellaneous databases

ChiTaRSiPkd1l3. mouse.
PROiQ2EG98.
SOURCEiSearch...

Gene expression databases

BgeeiQ2EG98.
CleanExiMM_PKD1L3.
ExpressionAtlasiQ2EG98. baseline and differential.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000203. GPS.
IPR013122. PKD1_2_channel.
IPR003915. PKD_2.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PfamiPF01825. GPS. 1 hit.
PF08016. PKD_channel. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR01433. POLYCYSTIN2.
SMARTiSM00303. GPS. 1 hit.
SM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50221. GPS. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes."
    Li A., Tian X., Sung S.-W., Somlo S.
    Genomics 81:596-608(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), ALTERNATIVE SPLICING.
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. Erratum
    Li A., Tian X., Sung S.-W., Somlo S.
    Genomics 82:498-500(2003)
  3. "Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells."
    LopezJimenez N.D., Cavenagh M.M., Sainz E., Cruz-Ithier M.A., Battey J.F., Sullivan S.L.
    J. Neurochem. 98:68-77(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 6), NUCLEOTIDE SEQUENCE [MRNA] OF 1405-2201 (ISOFORMS 3; 4 AND 5), NUCLEOTIDE SEQUENCE [MRNA] OF 829-2201 (ISOFORM 7), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Taste bud.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor."
    Ishimaru Y., Inada H., Kubota M., Zhuang H., Tominaga M., Matsunami H.
    Proc. Natl. Acad. Sci. U.S.A. 103:12569-12574(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PKD2L1, TISSUE SPECIFICITY.
  7. "Taste function in mice with a targeted mutation of the pkd1l3 gene."
    Nelson T.M., Lopezjimenez N.D., Tessarollo L., Inoue M., Bachmanov A.A., Sullivan S.L.
    Chem. Senses 35:565-577(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  8. "Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells."
    Kawaguchi H., Yamanaka A., Uchida K., Shibasaki K., Sokabe T., Maruyama Y., Yanagawa Y., Murakami S., Tominaga M.
    J. Biol. Chem. 285:17277-17281(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION.
  9. "A proton current drives action potentials in genetically identified sour taste cells."
    Chang R.B., Waters H., Liman E.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:22320-22325(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "The single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex."
    Fujimoto C., Ishimaru Y., Katano Y., Misaka T., Yamasoba T., Asakura T., Abe K.
    Biochem. Biophys. Res. Commun. 404:946-951(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-2059 AND GLU-2082.
  11. Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPK1L3_MOUSE
AccessioniPrimary (citable) accession number: Q2EG98
Secondary accession number(s): E9QPA5
, Q2EG93, Q2EG94, Q2EG95, Q2EG96, Q2EG97, Q2EG99, Q7TN87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Pkd1l3 and Pkd2l1 have been identified as sour taste receptor in gustatory cells based on a number of indirect evidences: Pkd2l1 is expressed in circumvallate papillae cells on the posterior part of the tongue distinct from those responsible for sweet, bitter and unami taste and genetic elimination of cells expressing Pkd2l1 reduces gustatory nerve responses to sour taste stimuli (PubMed:16891422, PubMed:16929298). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect: mice lacking Pkd1l3 do not show defects in sour taste perception (PubMed:20605874, PubMed:21625513). Moreover, the Pkd1l3-Pkd2l1 heteromer, when expressed in cells does not respond to acid stimuli used to evoke proton currents in taste cells (PubMed:21098668).5 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.