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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD

Organism
Helicosporidium sp. subsp. Simulium jonesii (Green alga)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57ZincUniRule annotation1
Metal bindingi60ZincUniRule annotation1
Metal bindingi76ZincUniRule annotation1
Metal bindingi79ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 79C4-typeUniRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaUniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotation
Encoded oniPlastid; Non-photosynthetic plastid
OrganismiHelicosporidium sp. subsp. Simulium jonesii (Green alga)
Taxonomic identifieri145475 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaTrebouxiophyceaeChlorellalesHelicosporidium

Subcellular locationi

Keywords - Cellular componenti

Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003090041 – 471Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST471

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2EEX4.
SMRiQ2EEX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 323CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 79C4-typeUniRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2EEX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILAWIKDK KNKAILNTPE YSSQSSLSWC FTHKEAASNK AVSFINLSKR
60 70 80 90 100
RALWTRCEKC GMIQFMRFFK ENANLCLSCS YHHIMTSDER IALLVEKGTW
110 120 130 140 150
YPLNETISPK DPIKFTDTQS YAQRIQSTQE KLGMQDAVQT GTGLINGIPF
160 170 180 190 200
AIGIMDFRFM GGSMGSVVGE KLTRLIEYAT KQGLFLLIVS ASGGARMQEG
210 220 230 240 250
IYSLMQMAKI SAALNVYQNE ANLLYISLCT SPTTGGVTAS FAMLGDIIFS
260 270 280 290 300
EPEAIIGFAG RRVIQQTLQQ ELPEDFQTSE SLLHHGLIDA IVPRCFLVNA
310 320 330 340 350
ISEVASIFAY APSKYKKLGN ISHYHENTLS WATEEILRRN CINNKKVEYR
360 370 380 390 400
TIEKIYQTTL YKESFFRLNK LLSKLKSEIN FTNKMKKQNN AFNTSSVYAN
410 420 430 440 450
YYDVMLCNYN IGTHSLNLLF NEESEFCKYF PFNMDHMKKE NRIKYNFITE
460 470
NSNDFIRKKT INDFSIMLIG D
Length:471
Mass (Da):53,744
Last modified:March 21, 2006 - v1
Checksum:i83E36D751BC162E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ398104 Genomic DNA. Translation: ABD33968.1.
RefSeqiYP_635920.1. NC_008100.1.

Genome annotation databases

GeneIDi4100439.

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiACCD_HELSJ
AccessioniPrimary (citable) accession number: Q2EEX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 21, 2006
Last modified: November 22, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families