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Protein

Free fatty acid receptor 4

Gene

Ffar4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Names & Taxonomyi

Protein namesi
Recommended name:
Free fatty acid receptor 4
Alternative name(s):
G-protein coupled receptor 120
Omega-3 fatty acid receptor 1
Gene namesi
Name:Ffar4
Synonyms:Gpr120, O3far1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308252. Ffar4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini67 – 77CytoplasmicSequence analysisAdd BLAST11
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 103ExtracellularSequence analysis5
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 156CytoplasmicSequence analysisAdd BLAST32
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 204ExtracellularSequence analysisAdd BLAST27
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 268CytoplasmicSequence analysisAdd BLAST43
Transmembranei269 – 289Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini290 – 295ExtracellularSequence analysis6
Transmembranei296 – 316Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini317 – 361CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3309099.
GuidetoPHARMACOLOGYi127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002629611 – 361Free fatty acid receptor 4Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated. FFA stimulation facilitates phosphorylation (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2AC31.
PRIDEiQ2AC31.

PTM databases

PhosphoSitePlusiQ2AC31.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021763.

Interactioni

Subunit structurei

Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032715.

Chemistry databases

BindingDBiQ2AC31.

Structurei

3D structure databases

ProteinModelPortaliQ2AC31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000009371.
HOVERGENiHBG051775.
InParanoidiQ2AC31.
KOiK08425.
OMAiCADLLFT.
OrthoDBiEOG091G0CDY.
PhylomeDBiQ2AC31.
TreeFamiTF336844.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2AC31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPECAQTTG PGPSRTPDQV NRTHFPFFSD VKGDHRLVLS VLETTVLGLI
60 70 80 90 100
FVVSLLGNVC ALVLVVRRRR RGATVSLVLN LFCADLLFTS AIPLVLVVRW
110 120 130 140 150
TEAWLLGPVV CHLLFYVMTM SGSVTILTLA AVSLERMVCI VRLRRGLSGP
160 170 180 190 200
GRRTQAALLA FIWGYSALAA LPLCILFRVV PQRLPGGDQE IPICTLDWPN
210 220 230 240 250
RIGEISWDVF FVTLNFLVPG LVIVISYSKI LQITKASRKR LTLSLAYSES
260 270 280 290 300
HQIRVSQQDY RLFRTLFLLM VSFFIMWSPI IITILLILIQ NFRQDLVIWP
310 320 330 340 350
SLFFWVVAFT FANSALNPIL YNMSLFRSEW RKIFCCFFFP EKGAIFTETS
360
IRRNDLSVIS T
Length:361
Mass (Da):40,902
Last modified:April 4, 2006 - v1
Checksum:i8444F22C1CB7DC0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB207868 mRNA. Translation: BAE80312.1.
RefSeqiNP_001040553.1. NM_001047088.1.
UniGeneiRn.82501.

Genome annotation databases

EnsembliENSRNOT00000034563; ENSRNOP00000032715; ENSRNOG00000021763.
GeneIDi294075.
KEGGirno:294075.
UCSCiRGD:1308252. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFFAR4_RAT
AccessioniPrimary (citable) accession number: Q2AC31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 4, 2006
Last modified: June 7, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families