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Protein

Sodium-dependent neutral amino acid transporter B(0)AT1

Gene

Slc6a19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent.By similarity

GO - Molecular functioni

GO - Biological processi

  • neutral amino acid transport Source: RGD
  • response to nutrient Source: RGD

Keywordsi

Biological processAmino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.
R-RNO-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter B(0)AT1
Alternative name(s):
Solute carrier family 6 member 19
System B(0) neutral amino acid transporter AT1
Gene namesi
Name:Slc6a19Imported
Synonyms:B0at1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1594328. Slc6a19.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 65ExtracellularSequence analysis3
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 119CytoplasmicSequence analysisAdd BLAST33
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 192ExtracellularSequence analysisAdd BLAST52
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 221CytoplasmicSequence analysis8
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 268ExtracellularSequence analysisAdd BLAST26
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 304CytoplasmicSequence analysisAdd BLAST15
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 413ExtracellularSequence analysisAdd BLAST88
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 456CytoplasmicSequence analysisAdd BLAST22
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Topological domaini478 – 490ExtracellularSequence analysisAdd BLAST13
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 531CytoplasmicSequence analysisAdd BLAST20
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 581ExtracellularSequence analysisAdd BLAST29
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 634CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994981 – 634Sodium-dependent neutral amino acid transporter B(0)AT1Add BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei627PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2A865.
PRIDEiQ2A865.

PTM databases

iPTMnetiQ2A865.
PhosphoSitePlusiQ2A865.

Expressioni

Inductioni

By high salt intake in SHR rats. Reduced level upon high salt intake in Wistar Kyoto rats.1 Publication

Gene expression databases

BgeeiENSRNOG00000026501.
GenevisibleiQ2A865. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028917.

Structurei

3D structure databases

ProteinModelPortaliQ2A865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ2A865.
KOiK05334.
OMAiGYVEECA.
OrthoDBiEOG091G08PX.
PhylomeDBiQ2A865.
TreeFamiTF343812.

Family and domain databases

InterProiView protein in InterPro
IPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
IPR037272. SNS_sf.
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiView protein in Pfam
PF00209. SNF. 1 hit.
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
SUPFAMiSSF161070. SSF161070. 2 hits.
PROSITEiView protein in PROSITE
PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2A865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRLVLPNPG LEDRIPSLDE LEVIEKEEAS SRPKWDNKAQ YMLTCVGFCV
60 70 80 90 100
GLGNVWRFPY LCQSHGGGAF MIPFLILLVL EGIPLLHLEF AIGQRLRKGS
110 120 130 140 150
VGVWSSIHPA LKGVGIASMF VSFMVGLYYN TIIAWVMWYF FNSFQEPLPW
160 170 180 190 200
SECPLNQNQT GYVEECAKSS SVDYFWYRET LNISTSISDS GSIQWWILLC
210 220 230 240 250
LTCAWSVLYV CTIRGIETTG KAVYITSTLP YVVLTIFLIR GLTLKGATNG
260 270 280 290 300
IVFLFTPNIT ELSNPNTWLD AGAQVFYSFS LAFGGLISFS SYNSVHNNCE
310 320 330 340 350
MDSVIVSIIN GFTSVYAATV VYSIIGFRAT ERFDDCVNTN ILTLINGFDL
360 370 380 390 400
PEGNVTAENF EAYQHWCNAT NPEAYAQLTF QTCDINTFLS EGVEGTGLAF
410 420 430 440 450
IVFTEAITKM PVSPLWSVLF FIMLFCLGLS SMFGNMEGVV VPLQDLNITP
460 470 480 490 500
KKWPKELLTG LICLGTYLIA FIFTLNSGQY WLSLLDSYAG SIPLLIIAFC
510 520 530 540 550
EMFAVVYVYG VDRFNKDIEF MIGHKPNIFW QVTWRVVSPL IMLVIFLFFF
560 570 580 590 600
VIEVNKQLMY SVWDPDYEEF PKSQKVPYPD WVYAVVVIVA GVPCLTIPCF
610 620 630
AIYKLIRNYC QKSGDQHGLV NALSTASVNG DLKN
Length:634
Mass (Da):71,232
Last modified:September 11, 2007 - v2
Checksum:i005015BEAF876CE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32R → K in CAI64591 (Ref. 1) Curated1
Sequence conflicti186S → P in CAI64591 (Ref. 1) Curated1
Sequence conflicti276F → Y in CAI64591 (Ref. 1) Curated1
Sequence conflicti433F → L in ABP63542 (PubMed:17646927).Curated1
Sequence conflicti458L → F in ABP63542 (PubMed:17646927).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ890206 mRNA. Translation: CAI64591.1.
EF474455 mRNA. Translation: ABP63542.1.
RefSeqiNP_001034811.1. NM_001039722.2.
UniGeneiRn.213283.

Genome annotation databases

EnsembliENSRNOT00000036714; ENSRNOP00000028917; ENSRNOG00000026501.
GeneIDi664630.
KEGGirno:664630.
UCSCiRGD:1594328. rat.

Similar proteinsi

Entry informationi

Entry nameiS6A19_RAT
AccessioniPrimary (citable) accession number: Q2A865
Secondary accession number(s): A4ZVM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 22, 2017
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families