Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Polyprotein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
PolyproteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 136Peptidase A2InterPro annotationAdd BLAST70
Domaini190 – 380Reverse transcriptaseInterPro annotationAdd BLAST191

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Family and domain databases

CDDicd05482. HIV_retropepsin_like. 1 hit.
Gene3Di2.40.70.10. 1 hit.
InterProiView protein in InterPro
IPR001969. Aspartic_peptidase_AS.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom_sf.
IPR034170. Retropepsin-like_cat_dom.
IPR018061. Retropepsins.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
PfamiView protein in Pfam
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q2A7P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AFPQGEAGEF SSEQTRANSP TSRELRVWGR NNPLSETGAE GQGSLSFPQI
60 70 80 90 100
TLWQRPLVSI KVGGQIKEAL LDTGADDTVL EEINLPGKWK PKMIGGIGGF
110 120 130 140 150
IKVRQYDQVP IEICGYKAIG TVLVGPTPVN IIGRNLLTQI GCTLNFPISP
160 170 180 190 200
IETVPVKLKP GMDGPKVKQW PLTEEKIKAL VEICTEMEKE GKISRIGPEN
210 220 230 240 250
PYNTPIFAIK KKDSTKWRKL VDFRELNKRT QDFWEVQLGI PHPAGLKKKK
260 270 280 290 300
SVTVLDVGDA YFSVPLDESF RKYTAFTIPS INNETPGIRY QYNVLPQGWK
310 320 330 340 350
GSPAIFQSSM IKILEPFKKQ NPELVIYQYM DDLYVGSDLE IGQHRTKIEK
360 370 380 390 400
LREHLLRWGL TTPDKKHQKE PPFLWMGYEL HPDKWTVQPI TLPEKESWTV
410 420 430 440 450
NDIQKLVGKL NWASQIYPGI KIKQLCKLLR GAKALTEVIP LTAEAELELA
460 470 480 490 500
ENREILKNPV HGVYYDPSKD LIAEVQKQGE GQWTYQIYQE PFKNLKTGKY
510 520 530 540 550
ARMRGAHTND IKQLTEAVQK IATESIVIWG KTPKFRLPIQ KETWEAWWRE
560 570 580
YWQATWIPEW EFVNTPPLVK LWYQLEKEPI IGAET
Length:585
Mass (Da):66,879
Last modified:April 4, 2006 - v1
Checksum:i20AFF574ED3A33DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei585Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM041003 Genomic DNA. Translation: CAJ13897.1.

Similar proteinsi

Entry informationi

Entry nameiQ2A7P4_9HIV1
AccessioniPrimary (citable) accession number: Q2A7P4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 22, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeSAAS annotation