Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q2A5V4 (TRPA_FRATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan synthase alpha chain
EC=4.2.1.20
Gene names
Name:trpA
Ordered Locus Names:FTL_0098
OrganismFrancisella tularensis subsp. holarctica (strain LVS) [Complete proteome] [HAMAP]
Taxonomic identifier376619 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella ›

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity. HAMAP-Rule MF_00131

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00131

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00131

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpA family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontryptophan synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Tryptophan synthase alpha chain HAMAP-Rule MF_00131
PRO_1000018204

Sites

Active site501Proton acceptor By similarity
Active site611Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2A5V4 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 7205F63022675742

FASTA26929,077
        10         20         30         40         50         60 
MTNRYTTLFA NLEKRNEGAF IPFVTIGDPN KALSFEIIDT LVSSGADALE LGIPFSDHLA 

        70         80         90        100        110        120 
DGPTIQEANI RALESGITPK DCFDILTKIR AKYPHIPIGL LLYANLVYAN GIENFYQKCL 

       130        140        150        160        170        180 
DAGVDSILIA DVPAHESKEF RDIAKKVGIA QIFIAPPDAS ESTLKQISKL GSGYTYLLSR 

       190        200        210        220        230        240 
VGVTGTETAA NMPVEDVLAK LREYNAPKPV LGFGISKPEQ VQQAIKAGAA GAISGSATVK 

       250        260 
IIQNNISNKQ KMLNELTYFV KEMKAATLN

« Hide

References

[1]"Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)."
Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LVS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM233362 Genomic DNA. Translation: CAJ78539.1.
RefSeqYP_512897.1. NC_007880.1.

3D structure databases

HSSPHSSP built from PDB template 1WBJ based on UniProtKB P00929.
ProteinModelPortalQ2A5V4.
SMRQ2A5V4. Positions 3-267.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ78539; CAJ78539; FTL_0098.
GeneID3952275.
KEGGftl:FTL_0098.
PATRIC17941055. VBIFraTul90181_0113.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0159.
HOGENOMHOG000223814.
KOK01695.
OMAYIYGVER.
ProtClustDBPRK13111.

Enzyme and pathway databases

BioCycFTUL376619:GI22-353-MONOMER.
UniPathwayUPA00035; UER00044.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00131. Trp_synth_alpha.
InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR00262. trpA. 1 hit.
PROSITEPS00167. TRP_SYNTHASE_ALPHA. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPA_FRATH
AccessionPrimary (citable) accession number: Q2A5V4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents