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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Francisella tularensis subsp. holarctica (strain LVS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton acceptorUniRule annotation
Active sitei61 – 611Proton acceptorUniRule annotation

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciFTUL376619:GI22-100-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpAUniRule annotation
Ordered Locus Names:FTL_0098
OrganismiFrancisella tularensis subsp. holarctica (strain LVS)
Taxonomic identifieri376619 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001944 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Tryptophan synthase alpha chainPRO_1000018204Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2A5V4.
SMRiQ2A5V4. Positions 3-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223814.
KOiK01695.
OMAiVFICPPN.
OrthoDBiEOG6RVG0K.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2A5V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNRYTTLFA NLEKRNEGAF IPFVTIGDPN KALSFEIIDT LVSSGADALE
60 70 80 90 100
LGIPFSDHLA DGPTIQEANI RALESGITPK DCFDILTKIR AKYPHIPIGL
110 120 130 140 150
LLYANLVYAN GIENFYQKCL DAGVDSILIA DVPAHESKEF RDIAKKVGIA
160 170 180 190 200
QIFIAPPDAS ESTLKQISKL GSGYTYLLSR VGVTGTETAA NMPVEDVLAK
210 220 230 240 250
LREYNAPKPV LGFGISKPEQ VQQAIKAGAA GAISGSATVK IIQNNISNKQ
260
KMLNELTYFV KEMKAATLN
Length:269
Mass (Da):29,077
Last modified:April 4, 2006 - v1
Checksum:i7205F63022675742
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ78539.1.
RefSeqiYP_512897.1. NC_007880.1.

Genome annotation databases

EnsemblBacteriaiCAJ78539; CAJ78539; FTL_0098.
KEGGiftl:FTL_0098.
PATRICi17941055. VBIFraTul90181_0113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ78539.1.
RefSeqiYP_512897.1. NC_007880.1.

3D structure databases

ProteinModelPortaliQ2A5V4.
SMRiQ2A5V4. Positions 3-267.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ78539; CAJ78539; FTL_0098.
KEGGiftl:FTL_0098.
PATRICi17941055. VBIFraTul90181_0113.

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223814.
KOiK01695.
OMAiVFICPPN.
OrthoDBiEOG6RVG0K.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.
BioCyciFTUL376619:GI22-100-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)."
    Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVS.

Entry informationi

Entry nameiTRPA_FRATH
AccessioniPrimary (citable) accession number: Q2A5V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: April 29, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.