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Q2A5V4

- TRPA_FRATH

UniProt

Q2A5V4 - TRPA_FRATH

Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Francisella tularensis subsp. holarctica (strain LVS)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501Proton acceptorUniRule annotation
    Active sitei61 – 611Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciFTUL376619:GI22-100-MONOMER.
    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
    Gene namesi
    Name:trpAUniRule annotation
    Ordered Locus Names:FTL_0098
    OrganismiFrancisella tularensis subsp. holarctica (strain LVS)
    Taxonomic identifieri376619 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001944: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Tryptophan synthase alpha chainPRO_1000018204Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ2A5V4.
    SMRiQ2A5V4. Positions 3-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0159.
    HOGENOMiHOG000223814.
    KOiK01695.
    OMAiRHEGAFV.
    OrthoDBiEOG6RVG0K.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00131. Trp_synth_alpha.
    InterProiIPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR002028. Trp_synthase_suA.
    [Graphical view]
    PfamiPF00290. Trp_syntA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00262. trpA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2A5V4-1 [UniParc]FASTAAdd to Basket

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    MTNRYTTLFA NLEKRNEGAF IPFVTIGDPN KALSFEIIDT LVSSGADALE    50
    LGIPFSDHLA DGPTIQEANI RALESGITPK DCFDILTKIR AKYPHIPIGL 100
    LLYANLVYAN GIENFYQKCL DAGVDSILIA DVPAHESKEF RDIAKKVGIA 150
    QIFIAPPDAS ESTLKQISKL GSGYTYLLSR VGVTGTETAA NMPVEDVLAK 200
    LREYNAPKPV LGFGISKPEQ VQQAIKAGAA GAISGSATVK IIQNNISNKQ 250
    KMLNELTYFV KEMKAATLN 269
    Length:269
    Mass (Da):29,077
    Last modified:April 4, 2006 - v1
    Checksum:i7205F63022675742
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM233362 Genomic DNA. Translation: CAJ78539.1.
    RefSeqiYP_512897.1. NC_007880.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ78539; CAJ78539; FTL_0098.
    GeneIDi3952275.
    KEGGiftl:FTL_0098.
    PATRICi17941055. VBIFraTul90181_0113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM233362 Genomic DNA. Translation: CAJ78539.1 .
    RefSeqi YP_512897.1. NC_007880.1.

    3D structure databases

    ProteinModelPortali Q2A5V4.
    SMRi Q2A5V4. Positions 3-267.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ78539 ; CAJ78539 ; FTL_0098 .
    GeneIDi 3952275.
    KEGGi ftl:FTL_0098.
    PATRICi 17941055. VBIFraTul90181_0113.

    Phylogenomic databases

    eggNOGi COG0159.
    HOGENOMi HOG000223814.
    KOi K01695.
    OMAi RHEGAFV.
    OrthoDBi EOG6RVG0K.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .
    BioCyci FTUL376619:GI22-100-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00131. Trp_synth_alpha.
    InterProi IPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR002028. Trp_synthase_suA.
    [Graphical view ]
    Pfami PF00290. Trp_syntA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00262. trpA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)."
      Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LVS.

    Entry informationi

    Entry nameiTRPA_FRATH
    AccessioniPrimary (citable) accession number: Q2A5V4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3