Reviewed, UniProtKB/Swiss-Prot Q2A4V3 (GCST_FRATH)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	FTL_0477

Organism

Francisella tularensis subsp. holarctica (strain LVS) [Complete proteome] [HAMAP]

Taxonomic identifier

376619 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity.
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Aminomethyltransferase HAMAP MF_00259		PRO_1000047668

Sequences

	Sequence		Length	Mass (Da)
	Q2A4V3-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 52C8DD19F908945E	FASTA	358	39,516
	10 20 30 40 50 60 MLKTPLYESH IAANAKMIDF SGWSMPINYG SQIQEHNNVR EDCGIFDVSH MLAVDIQGSE 70 80 90 100 110 120 AEKFLRYLLA NDVAKLQENK AQYGCMLNHD AGIVDDLITY KVTDEHFRIV VNAGNRESDV 130 140 150 160 170 180 AWFNQNAQNF DVAITPQTDL AIVAVQGPKA VAVIKRVVTK EIAAEIEALL PFSFKFFSKW 190 200 210 220 230 240 MVARTGYTGE DGFEVILPAT QVKKFWDSLL ENGAQPAGLG ARDTLRLEAG MHLYGADMDT 250 260 270 280 290 300 STTPLERGLG WSVDLSDEHR DFIGKKAYLA KKAQGVDTKW VGVVLKTKGV LRAGQEIDFD 310 320 330 340 350 NGEKGYITSG SFSPTLKVAI GLAYVPKQAD NPVVNIRGKE LEVELVKPKF VKNGKSLI

References

[1]

"Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)." Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM233362 Genomic DNA. Translation: CAJ78917.1.
RefSeq	YP_513249.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3952535.
GenomeReviews	Gene locus FTL_0477 in contig AM233362_GR.
KEGG	ftl:FTL_0477.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2A4V3.
OMA	Q2A4V3. VEIRGKW.
Enzyme and pathway databases
BioCyc	FTUL351581:FTL_0477-MON.
Family and domain databases
HAMAP	MF_00259. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_FRATH

Accession

Primary (citable) accession number: Q2A4V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 4, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)