Q2A4V3 (GCST_FRATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	FTL_0477

Organism

Francisella tularensis subsp. holarctica (strain LVS) [Complete proteome] [HAMAP]

Taxonomic identifier

376619 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Aminomethyltransferase HAMAP MF_00259		PRO_1000047668

Sequences

	Sequence		Length	Mass (Da)
	Q2A4V3 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 52C8DD19F908945E	FASTA	358	39,516
	10 20 30 40 50 60 MLKTPLYESH IAANAKMIDF SGWSMPINYG SQIQEHNNVR EDCGIFDVSH MLAVDIQGSE 70 80 90 100 110 120 AEKFLRYLLA NDVAKLQENK AQYGCMLNHD AGIVDDLITY KVTDEHFRIV VNAGNRESDV 130 140 150 160 170 180 AWFNQNAQNF DVAITPQTDL AIVAVQGPKA VAVIKRVVTK EIAAEIEALL PFSFKFFSKW 190 200 210 220 230 240 MVARTGYTGE DGFEVILPAT QVKKFWDSLL ENGAQPAGLG ARDTLRLEAG MHLYGADMDT 250 260 270 280 290 300 STTPLERGLG WSVDLSDEHR DFIGKKAYLA KKAQGVDTKW VGVVLKTKGV LRAGQEIDFD 310 320 330 340 350 NGEKGYITSG SFSPTLKVAI GLAYVPKQAD NPVVNIRGKE LEVELVKPKF VKNGKSLI

References

[1]

"Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)." Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LVS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM233362 Genomic DNA. Translation: CAJ78917.1.
RefSeq	YP_513249.1. NC_007880.1.
3D structure databases
ProteinModelPortal	Q2A4V3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3952535.
GenomeReviews	Gene locus FTL_0477 in contig AM233362_GR.
KEGG	ftl:FTL_0477.
PATRIC	17941908. VBIFraTul90181_0521.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	Q2A4V3.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	FTUL351581:FTL_0477-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_FRATH

Accession

Primary (citable) accession number: Q2A4V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 4, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program