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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Francisella tularensis subsp. holarctica (strain LVS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciFTUL376619:GI22-498-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:FTL_0477
OrganismiFrancisella tularensis subsp. holarctica (strain LVS)
Taxonomic identifieri376619 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358AminomethyltransferasePRO_1000047668Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi376619.FTL_0477.

Structurei

3D structure databases

ProteinModelPortaliQ2A4V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D43. Bacteria.
COG0404. LUCA.
HOGENOMiHOG000239381.
KOiK00605.
OMAiLGWLVHL.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT. 1 hit.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2A4V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTPLYESH IAANAKMIDF SGWSMPINYG SQIQEHNNVR EDCGIFDVSH
60 70 80 90 100
MLAVDIQGSE AEKFLRYLLA NDVAKLQENK AQYGCMLNHD AGIVDDLITY
110 120 130 140 150
KVTDEHFRIV VNAGNRESDV AWFNQNAQNF DVAITPQTDL AIVAVQGPKA
160 170 180 190 200
VAVIKRVVTK EIAAEIEALL PFSFKFFSKW MVARTGYTGE DGFEVILPAT
210 220 230 240 250
QVKKFWDSLL ENGAQPAGLG ARDTLRLEAG MHLYGADMDT STTPLERGLG
260 270 280 290 300
WSVDLSDEHR DFIGKKAYLA KKAQGVDTKW VGVVLKTKGV LRAGQEIDFD
310 320 330 340 350
NGEKGYITSG SFSPTLKVAI GLAYVPKQAD NPVVNIRGKE LEVELVKPKF

VKNGKSLI
Length:358
Mass (Da):39,516
Last modified:April 4, 2006 - v1
Checksum:i52C8DD19F908945E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ78917.1.
RefSeqiWP_004336875.1. NZ_CP009694.1.

Genome annotation databases

EnsemblBacteriaiCAJ78917; CAJ78917; FTL_0477.
KEGGiftl:FTL_0477.
PATRICi17941908. VBIFraTul90181_0521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ78917.1.
RefSeqiWP_004336875.1. NZ_CP009694.1.

3D structure databases

ProteinModelPortaliQ2A4V3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi376619.FTL_0477.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ78917; CAJ78917; FTL_0477.
KEGGiftl:FTL_0477.
PATRICi17941908. VBIFraTul90181_0521.

Phylogenomic databases

eggNOGiENOG4105D43. Bacteria.
COG0404. LUCA.
HOGENOMiHOG000239381.
KOiK00605.
OMAiLGWLVHL.

Enzyme and pathway databases

BioCyciFTUL376619:GI22-498-MONOMER.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT. 1 hit.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCST_FRATH
AccessioniPrimary (citable) accession number: Q2A4V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.