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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Francisella tularensis subsp. holarctica (strain LVS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:FTL_0477
OrganismiFrancisella tularensis subsp. holarctica (strain LVS)
Taxonomic identifieri376619 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000476681 – 358AminomethyltransferaseAdd BLAST358

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2A4V3.
SMRiQ2A4V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D43. Bacteria.
COG0404. LUCA.
HOGENOMiHOG000239381.
KOiK00605.
OMAiRITRCGY.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
HAMAPiMF_00259. GcvT. 1 hit.
InterProiView protein in InterPro
IPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/YgfZ/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
PfamiView protein in Pfam
PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2A4V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTPLYESH IAANAKMIDF SGWSMPINYG SQIQEHNNVR EDCGIFDVSH
60 70 80 90 100
MLAVDIQGSE AEKFLRYLLA NDVAKLQENK AQYGCMLNHD AGIVDDLITY
110 120 130 140 150
KVTDEHFRIV VNAGNRESDV AWFNQNAQNF DVAITPQTDL AIVAVQGPKA
160 170 180 190 200
VAVIKRVVTK EIAAEIEALL PFSFKFFSKW MVARTGYTGE DGFEVILPAT
210 220 230 240 250
QVKKFWDSLL ENGAQPAGLG ARDTLRLEAG MHLYGADMDT STTPLERGLG
260 270 280 290 300
WSVDLSDEHR DFIGKKAYLA KKAQGVDTKW VGVVLKTKGV LRAGQEIDFD
310 320 330 340 350
NGEKGYITSG SFSPTLKVAI GLAYVPKQAD NPVVNIRGKE LEVELVKPKF

VKNGKSLI
Length:358
Mass (Da):39,516
Last modified:April 4, 2006 - v1
Checksum:i52C8DD19F908945E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ78917.1.
RefSeqiWP_004336875.1. NZ_CP009694.1.

Genome annotation databases

EnsemblBacteriaiCAJ78917; CAJ78917; FTL_0477.
KEGGiftl:FTL_0477.

Similar proteinsi

Entry informationi

Entry nameiGCST_FRATH
AccessioniPrimary (citable) accession number: Q2A4V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 4, 2006
Last modified: September 27, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families