Reviewed, UniProtKB/Swiss-Prot Q2A4V1 (GCSPA_FRATH)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	FTL_0479

Organism

Francisella tularensis subsp. holarctica (strain LVS) [Complete proteome] [HAMAP]

Taxonomic identifier

376619 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045651

Sequences

	Sequence		Length	Mass (Da)
	Q2A4V1-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 02B10BD6E9DB2715	FASTA	455	49,667
	10 20 30 40 50 60 MSFIPHKLEQ IKKMLDTIGA SSVDQLFDEI PRHLRADTLN IKDGINEIQL ANLMRKRANK 70 80 90 100 110 120 NHHNINYIGA GAYSHHIPAA IWDIVARGEF YTAYTPYQAE ASQGGLQVIY EFQTMMAGLT 130 140 150 160 170 180 GMDASNASMY DGATALAESV LMAIRSNKKA KSQKVLIAEA LHPTYLRVLE TITKHQGIEF 190 200 210 220 230 240 DIVNLDSKNG KTDVTKLEDF ANTNYAAVVI QSPNFLGQLA DVDGITNWAH KHGALVIAVT 250 260 270 280 290 300 NPMSLAILKS PAEWGDNGAD IVCGEGQPIG VPLASGGPYF GFMTCKMAHV RQMPGRIVGR 310 320 330 340 350 360 TVDLDGNEGF CLTLQAREQH IRRAKATSNI CTNQGLMVTA ATIYMSLLGA EGLERVASIS 370 380 390 400 410 420 HENTQTLATE LAKINGVSIR FNSAFFNEVV IDLPVNAETF VTEMEKEAID AGYFLGEYHS 430 440 450 DLANSIMVCA TEIHTSEDIK EYIEATKKVL ARIGG

References

[1]

"Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)." Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM233362 Genomic DNA. Translation: CAJ78919.1.
RefSeq	YP_513251.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3952537.
GenomeReviews	Gene locus FTL_0479 in contig AM233362_GR.
KEGG	ftl:FTL_0479.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2A4V1.
OMA	Q2A4V1. VANASMY.
Enzyme and pathway databases
BioCyc	FTUL351581:FTL_0479-MON.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_FRATH

Accession

Primary (citable) accession number: Q2A4V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 4, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)