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Protein

dTDP-glucose 4,6-dehydratase

Gene

FTL_0606

Organism
Francisella tularensis subsp. holarctica (strain LVS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.UniRule annotation

Cofactori

NAD(+)UniRule annotation

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. dTDP-glucose 4,6-dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. nucleotide-sugar metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Enzyme and pathway databases

BioCyciFTUL376619:GI22-628-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-glucose 4,6-dehydrataseUniRule annotation (EC:4.2.1.46UniRule annotation)
Gene namesi
Ordered Locus Names:FTL_0606Imported
OrganismiFrancisella tularensis subsp. holarctica (strain LVS)Imported
Taxonomic identifieri376619 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001944: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ2A4I6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000168006.
KOiK01710.
OMAiMNNTILV.
OrthoDBiEOG6PZXCX.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10366:SF41. PTHR10366:SF41. 1 hit.
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01181. dTDP_gluc_dehyt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2A4I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNEKMNYKP KNILVTGAAG FIGSNYVRIM LSRYSDIKII SYDKLTYAGS
60 70 80 90 100
LDNLKDLNNE HNHIFIKGDI CDEVLVYQTL KEYKIDTIVH FAAESHVDNS
110 120 130 140 150
IANPKVFLET NVIGTFTLLD CAKRYWLDEL GLEETSCRFH HISTDEVYGT
160 170 180 190 200
LAKDEPAFTE IKAYEPNSPY SASKAGSDHI ARAYHHTYKL PVTISNCSNN
210 220 230 240 250
YGPYQHREKL IPVVINSCIN YKPIPIYGDG SNIRDWLYVE DHCDAIQTIV
260 270 280 290 300
EKGVVGEVYN IGGINEVDNL TLVKTICKLM DEYKPENAPH SNLITFVEDR
310 320 330
KGHDWRYAID NSKIQNELGW KPSQDFDKMF RQTIEFYL
Length:338
Mass (Da):38,787
Last modified:April 4, 2006 - v1
Checksum:iB35E0F8D788CE254
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ79046.1.
RefSeqiYP_513366.1. NC_007880.1.

Genome annotation databases

EnsemblBacteriaiCAJ79046; CAJ79046; FTL_0606.
GeneIDi3951334.
KEGGiftl:FTL_0606.
PATRICi17942199. VBIFraTul90181_0665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ79046.1.
RefSeqiYP_513366.1. NC_007880.1.

3D structure databases

ProteinModelPortaliQ2A4I6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ79046; CAJ79046; FTL_0606.
GeneIDi3951334.
KEGGiftl:FTL_0606.
PATRICi17942199. VBIFraTul90181_0665.

Phylogenomic databases

HOGENOMiHOG000168006.
KOiK01710.
OMAiMNNTILV.
OrthoDBiEOG6PZXCX.

Enzyme and pathway databases

BioCyciFTUL376619:GI22-628-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10366:SF41. PTHR10366:SF41. 1 hit.
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01181. dTDP_gluc_dehyt. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)."
    Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVSImported.

Entry informationi

Entry nameiQ2A4I6_FRATH
AccessioniPrimary (citable) accession number: Q2A4I6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.