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Q2A3K7

- MDH_FRATH

UniProt

Q2A3K7 - MDH_FRATH

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Protein

Malate dehydrogenase

Gene
mdh, FTL_0987
Organism
Francisella tularensis subsp. holarctica (strain LVS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NAD By similarity
Binding sitei83 – 831Substrate By similarity
Binding sitei89 – 891Substrate By similarity
Binding sitei96 – 961NAD By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei152 – 1521Substrate By similarity
Active sitei176 – 1761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NAD By similarity
Nucleotide bindingi119 – 1213NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciFTUL376619:GI22-1013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:FTL_0987
OrganismiFrancisella tularensis subsp. holarctica (strain LVS)
Taxonomic identifieri376619 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001944: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Malate dehydrogenaseUniRule annotationPRO_1000026472Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi119857.FTL_0987.

Structurei

3D structure databases

ProteinModelPortaliQ2A3K7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000213794.
KOiK00024.
OMAiDANIVEC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2A3K7-1 [UniParc]FASTAAdd to Basket

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MARKKITLVG AGNIGGTLAH LALIKQLGDV VLFDIAQGMP NGKALDLLQT    50
CPIEGVDFKV RGTNDYKDLE NSDVVIVTAG VPRKPGMSRD DLLGINIKVM 100
QTVGEGIKHN CPNAFVICIT NPLDIMVNML QKFSGVPDNK IVGMAGVLDS 150
ARFRTFLADE LNVSVQQVQA YVMGGHGDTM VPLTKMSNVA GVSLEQLVKE 200
GKLKQERLDA IVSRTRSGGG EIVALLKTGS AYYAPAAAGI QMAESFLKDK 250
KMILPCAAKV KAGMYGLDED LFVGVPTEIS ANGVRPIEVE ISDKEREQLQ 300
VSINAVKDLN KAAAEILAK 319
Length:319
Mass (Da):34,077
Last modified:June 13, 2006 - v1
Checksum:i13749C47CF07D34D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM233362 Genomic DNA. Translation: CAJ79426.1.
RefSeqiYP_513695.1. NC_007880.1.

Genome annotation databases

EnsemblBacteriaiCAJ79426; CAJ79426; FTL_0987.
GeneIDi3951214.
KEGGiftl:FTL_0987.
PATRICi17943026. VBIFraTul90181_1070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM233362 Genomic DNA. Translation: CAJ79426.1 .
RefSeqi YP_513695.1. NC_007880.1.

3D structure databases

ProteinModelPortali Q2A3K7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 119857.FTL_0987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ79426 ; CAJ79426 ; FTL_0987 .
GeneIDi 3951214.
KEGGi ftl:FTL_0987.
PATRICi 17943026. VBIFraTul90181_1070.

Phylogenomic databases

HOGENOMi HOG000213794.
KOi K00024.
OMAi DANIVEC.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci FTUL376619:GI22-1013-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)."
    Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVS.

Entry informationi

Entry nameiMDH_FRATH
AccessioniPrimary (citable) accession number: Q2A3K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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