ID   BIOD_FRATH              Reviewed;         219 AA.
AC   Q2A2V6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=Dethiobiotin synthetase;
DE            EC=6.3.3.3;
DE   AltName: Full=Dethiobiotin synthase;
DE   AltName: Full=DTB synthetase;
DE            Short=DTBS;
GN   Name=bioD; OrderedLocusNames=FTL_1275;
OS   Francisella tularensis subsp. holarctica (strain LVS).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=376619;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S.,
RA   Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R.,
RA   Garcia E.;
RT   "Complete genome sequence of Francisella tularensis LVS (Live Vaccine
RT   Strain).";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + 7,8-diaminononanoate + CO(2) = ADP +
CC       phosphate + dethiobiotin.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from
CC       6-carboxyhexanoyl-CoA: step 3/4.
CC   -!- SIMILARITY: Belongs to the dethiobiotin synthetase family.
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DR   EMBL; AM233362; CAJ79714.1; -; Genomic_DNA.
DR   RefSeq; YP_513946.1; -.
DR   GeneID; 3951959; -.
DR   GenomeReviews; AM233362_GR; FTL_1275.
DR   KEGG; ftl:FTL_1275; -.
DR   HOGENOM; Q2A2V6; -.
DR   OMA; Q2A2V6; CLIEGAG.
DR   BioCyc; FTUL351581:FTL_1275-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004141; F:dethiobiotin synthase activity; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00336; -; 1.
DR   InterPro; IPR004472; BioD_synth.
DR   PIRSF; PIRSF006755; DTB_synth; 1.
DR   TIGRFAMs; TIGR00347; bioD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Biotin biosynthesis; Complete proteome; Ligase;
KW   Magnesium; Nucleotide-binding.
FT   CHAIN         1    219       Dethiobiotin synthetase.
FT                                /FTId=PRO_0000302505.
FT   NP_BIND       8     16       ATP (By similarity).
SQ   SEQUENCE   219 AA;  24502 MW;  090B0BF3DAD24657 CRC64;
     MKKFFIIGTN TEVGKTYIST KLIEVCEHQN IKSLCLKPVA SGQSQFSELC EDVESILNAY
     KHKFTAAEIN LISFNQAVAP HIIAAKTKVD ISIENLKQFI EDKYNQDLDI LFIEGAGGLL
     TPYSDHTTQL DLIKALQIPV LLVSAIKVGC INHTLLTINE LNRHNIKLAG WIANCNDSNI
     KYIDEQINTI EELSGYKCSA KISRNADYLD FIDLSKILI
//