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Protein

Glutamine--tRNA ligase

Gene

FTL_1617

Organism
Francisella tularensis subsp. holarctica (strain LVS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutaminyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFTUL376619:GI22-1658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligaseSAAS annotation (EC:6.1.1.18SAAS annotation)
Gene namesi
Ordered Locus Names:FTL_1617Imported
OrganismiFrancisella tularensis subsp. holarctica (strain LVS)Imported
Taxonomic identifieri376619 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001944: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ2A1Z6.
SMRiQ2A1Z6. Positions 10-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000259232.
KOiK01886.
OMAiVTHSICT.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2A1Z6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSEIKVNKT NFIKNIIKKD LETNKVSSIL TRFPPEPNGY LHIGHAKSIC
60 70 80 90 100
LNFGIAQEFD GKCNLRFDDT NPDKEDIEYI NAIQEDVEWL GFKWENQPRF
110 120 130 140 150
ASEYFDKMYE LAILLIKKGK AYVCDLSAEE IRAYRGTLKE PGKNSPYRER
160 170 180 190 200
SITENLELFE EMKNGKFAEG SKTLRAKIDM SSGNINLRDP ALYRIKFSHH
210 220 230 240 250
PKTGDKWCIY PMYTFAHPLE DAIEKITHSL CTLEFQDQRP FYDWVIEETE
260 270 280 290 300
FSIKPQQIEF SRLNLNYTIT SKRKLKYLVD NKLVNGWDDP RMPTIKGYRR
310 320 330 340 350
RGYTPESIRN FCEMIGISKQ DSVIDVSVLE DAIRDDLNKS VLRKNVVLDP
360 370 380 390 400
IRVSIKDMPN HHLDVPNHPQ DPEFGRREIT ISSQIFIERD DFVFKLEKDM
410 420 430 440 450
KKLSPNGRVR LLNSYVIECQ EVITDTSGEV IELKCSYLPE TLGGKKPNDG
460 470 480 490 500
IKPNGIIHWV DANNCLDAEV RIYDRLFNDE NPANADRIED VLNPDSLQVI
510 520 530 540
KNAKVERSLE SVKAEERFQF NRVGYFIADL KDCSNDTLVF NRIATLRN
Length:548
Mass (Da):63,594
Last modified:April 4, 2006 - v1
Checksum:i980EC18F509FD70D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ80056.1.
RefSeqiYP_514256.1. NC_007880.1.

Genome annotation databases

EnsemblBacteriaiCAJ80056; CAJ80056; FTL_1617.
GeneIDi3952005.
KEGGiftl:FTL_1617.
PATRICi17944434. VBIFraTul90181_1757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ80056.1.
RefSeqiYP_514256.1. NC_007880.1.

3D structure databases

ProteinModelPortaliQ2A1Z6.
SMRiQ2A1Z6. Positions 10-548.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ80056; CAJ80056; FTL_1617.
GeneIDi3952005.
KEGGiftl:FTL_1617.
PATRICi17944434. VBIFraTul90181_1757.

Phylogenomic databases

HOGENOMiHOG000259232.
KOiK01886.
OMAiVTHSICT.
OrthoDBiEOG6DRPF7.

Enzyme and pathway databases

BioCyciFTUL376619:GI22-1658-MONOMER.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)."
    Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVSImported.

Entry informationi

Entry nameiQ2A1Z6_FRATH
AccessioniPrimary (citable) accession number: Q2A1Z6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: February 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.