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Q2A1W9 (GLPK_FRATH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:FTL_1644
OrganismFrancisella tularensis subsp. holarctica (strain LVS) [Complete proteome] [HAMAP]
Taxonomic identifier376619 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Glycerol kinase HAMAP MF_00186
PRO_1000058449

Regions

Nucleotide binding412 – 4165ATP By similarity

Sites

Binding site131Substrate By similarity
Binding site171ATP By similarity
Binding site831Substrate By similarity
Binding site1361Substrate By similarity
Binding site2461Substrate By similarity
Binding site2681ATP By similarity
Binding site3111ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2A1W9 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 853AC3C05CEBDB80

FASTA50255,818
        10         20         30         40         50         60 
MSKDFILAID QGTTSSRAII FDKKGNIRKI AQKEFTQIYP KSGWVEHDAM EIWGTQSGVM 

        70         80         90        100        110        120 
REALEFGRVK PDQIAAIGIT NQRETVVVWD KETGDPVYNA IVWQCRRTSS ICDEIKRDPQ 

       130        140        150        160        170        180 
FVKYIKENTG LVVDAYFSGT KVKWILDNVE GAREKANAGK LLMGTIDTWL IWNLTRGKVH 

       190        200        210        220        230        240 
ATDYSNASRT MLFNINSLEW DKKILDYLNI PESMLPEVKN SSEVFGVTDS HTLGGAEIPI 

       250        260        270        280        290        300 
AGVAGDQHAA LFGHCCFEKG MAKNTYGTGC FALMNVGDKP VYSDEGLLTT IAWAENGKPT 

       310        320        330        340        350        360 
YALEGSIFIV GAVIQWIRDG LGLVRSAEDS EYYATKIDST NGVYLVPAFV GLGTPYWDMY 

       370        380        390        400        410        420 
ARGTIVGITR DTKREHIIRA ALEAIAYQAK DVLECMKEDT GLDLAGLRVD GGAVQNNFLM 

       430        440        450        460        470        480 
QFQSDILQSE ISKPKINEIT SLGAVFLAGL AVGFWKDKQE LKSILTTEKV FEPQKDSQAV 

       490        500 
AHDYRGWKKA VERSKAWAEC YS

« Hide

References

[1]"Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)."
Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LVS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM233362 Genomic DNA. Translation: CAJ80083.1.
RefSeqYP_514283.1. NC_007880.1.

3D structure databases

ProteinModelPortalQ2A1W9.
SMRQ2A1W9. Positions 3-499.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3952755.
GenomeReviewsGene locus FTL_1644 in contig AM233362_GR.
KEGGftl:FTL_1644.
PATRIC17944499. VBIFraTul90181_1789.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMAADTIGMP.
PhylomeDBQ2A1W9.
ProtClustDBCLSK934381.

Enzyme and pathway databases

BioCycFTUL351581:FTL_1644-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_FRATH
AccessionPrimary (citable) accession number: Q2A1W9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 4, 2006
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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