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Reviewed, UniProtKB/Swiss-Prot Q2A1K3 (ACON_FRATH)

Last modified February 9, 2010. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Aconitate hydratase
      Short name=Aconitase
    EC=4.2.1.3
Alternative name(s):
    Citrate hydro-lyase
Gene names
Name: acn
Ordered Locus Names: FTL_1772
OrganismFrancisella tularensis subsp. holarctica (strain LVS) [Complete proteome] [HAMAP]
Taxonomic identifier376619 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Protein attributes

Sequence length937 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Citrate = isocitrate.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Ligand4Fe-4S
Iron
Iron-sulfur
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function4 iron, 4 sulfur cluster binding

Inferred from electronic annotation. Source: UniProtKB-KW

aconitate hydratase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 937937Aconitate hydratase
PRO_0000235166

Sites

Metal binding4391Iron-sulfur (4Fe-4S) By similarity
Metal binding5051Iron-sulfur (4Fe-4S) By similarity
Metal binding5081Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2A1K3-1 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 3784B39F6F6980C9

FASTA937102,704
        10         20         30         40         50         60 
MSDIKNITKL QIEDKGKKYS LYSLKKLSQE LGKDVTRLPY SIRVLLENQL RNIDGYKVKE 

        70         80         90        100        110        120 
DDMHKVLDWD AKASSRPEIP HMPARVVMQD FTGVPAVVDL AAMRKAIKDA GGDADKINPL 

       130        140        150        160        170        180 
VDTAMVIDHS VQVDFYGTKT ALAQNVAKEF ERNGERYSLL KWAQKAFDDF IVVPPGMGII 

       190        200        210        220        230        240 
HQVNLEYLAK DALVKNINGE DVIYPDTLVG TDSHTTMING VGAVGWGVGG IEAEAVMLGQ 

       250        260        270        280        290        300 
PYYMVLPDVV GVKFTGKLKT GVTATDLVLK VTEVLRKHGV VGKFVEYYGE GLESLSLPDR 

       310        320        330        340        350        360 
ATIANMTPEY GATIGFFPVD EVTLDFFNNT NRSELVDAAR EMYKEQLLFR ENPAEEPEYS 

       370        380        390        400        410        420 
NIVEIDLSEV ESNLAGPKRP QDRVAFHDMK KAFAEALVHE QGLHGFGLTD EQLQKSAEVK 

       430        440        450        460        470        480 
GLNERITHGS VAIAAITSCT NTSNPSLLLG AGLLAKKANE KGLKVKPFVK TSLAPGSQVV 

       490        500        510        520        530        540 
TQYLEKANLL PELENLGFNL VGYGCTTCIG NSGPLDEPVV EAINEADLIV ASVSSGNRNF 

       550        560        570        580        590        600 
EGRINPHIKA NYLASPIHVV AYALAGTVDF DPVEDAIGKD AEGNDVYLAD IWPTTEEIAA 

       610        620        630        640        650        660 
IQSHVINSDM FKKAYATVLD GTEEWQKLKA PEGKLYEFDS SSTYIQCPNF FEKFAEGNDD 

       670        680        690        700        710        720 
LDIKGARTLL MLGDSVTTDH ISPAGAIPEE YPAGQYLKSH GVEKKDFNSY GSRRGNHEVM 

       730        740        750        760        770        780 
MRGTFANIRI RNLLLDNVEG GFTKYHLDGS QQYVFDAAMK YKEKGIPLVI LAGKEYGTGS 

       790        800        810        820        830        840 
SRDWAAKGTF LLGVKAVIAE SYERIHRSNL VGMGVLPLEY VNGQNAKTLG LDGTEMFNIK 

       850        860        870        880        890        900 
NLNNIKPRQI VIVEAVHPKT AHTTTFEALA RLDADVDVDY LKNGGILQTV LKDIMGDKKE 

       910        920        930 
SKSTQSTTSK GCGSADTSSE TSCPFAKIAN FFKKLFK 

« Hide

References

[1]"Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)."
Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM233362 Genomic DNA. Translation: CAJ80211.1.
RefSeqYP_514399.1.

3D structure databases

SMRQ2A1K3. Positions 8-895.
ModBaseSearch...

Genome annotation databases

GeneID3951896.
GenomeReviewsGene locus FTL_1772 in contig AM233362_GR.
KEGGftl:FTL_1772.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289738.
OMAYSKAQGM.

Enzyme and pathway databases

BioCycFTUL351581:FTL_1772-MONOMER.

Family and domain databases

InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015937. Aconitase-like_core.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR006249. Aconitase/Fe_reg_prot_2.
IPR015934. Aconitase/Fe_reg_prot_2/AcnD.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
Gene3DG3DSA:3.30.499.10. Acnase/IPM_dHydase_lsu_aba_1/3. 2 hits.
G3DSA:3.20.19.10. Aconitase/3IPM_dehydase_swvl. 1 hit.
G3DSA:3.40.1060.10. Aconitase/IPMdHydase_lsu_aba_2. 1 hit.
PANTHERPTHR11670. Aconitase-like_core. 1 hit.
PTHR11670:SF1. Aconitase/Fe_reg_prot_2/AcnD. 1 hit.
PfamPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSPR00415. ACONITASE.
TIGRFAMsTIGR01341. aconitase_1. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACON_FRATH
AccessionPrimary (citable) accession number: Q2A1K3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: April 4, 2006
Last modified: February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents