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Protein

Glutamate decarboxylase

Gene

FTL_1863

Organism
Francisella tularensis subsp. holarctica (strain LVS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciFTUL376619:GI22-1913-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:FTL_1863Imported
OrganismiFrancisella tularensis subsp. holarctica (strain LVS)Imported
Taxonomic identifieri376619 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001944: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi119857.FTL_1863.

Structurei

3D structure databases

ProteinModelPortaliQ2A1C2.
SMRiQ2A1C2. Positions 13-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiFAREPIS.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2A1C2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALHGKKDTI DNLDFFEQSL PKFKLPLNSQ DPLEVYQEIK DELMLDGNSK
60 70 80 90 100
QNLETFCQTE VDDFIHKLMD DCIDKNMIDK DEYPQTAEIE SRCVNILANL
110 120 130 140 150
WNSSAENAIG CSTTGSSEAA MLGGMAMKWR WRDKMKAQGK DYTKPNLVTG
160 170 180 190 200
PVQVCWHKFA RYWDIELREI PMSNESLIMT PEAVLERCDE NTIGVVPTLG
210 220 230 240 250
VTFTGQYEPV EQVCKALDDF ERQTGVDIPV HVDAASGGFL APFVEPELKW
260 270 280 290 300
DFRLPISPLG VGWVIWADKK YLPDDLIFNV NYLGGNMPTF ALNFSRPGGQ
310 320 330 340 350
IVAQYYNFVR LGFEGYKKVH QLCYDIAEYI AKELRKMEIF EIIHAGEGGI
360 370
PAVSWSLKAT KEYSLFDISE SSR
Length:373
Mass (Da):42,362
Last modified:April 4, 2006 - v1
Checksum:i0911AA3E533856C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ80302.1.
RefSeqiWP_003017427.1. NC_007880.1.
YP_514480.1. NC_007880.1.

Genome annotation databases

EnsemblBacteriaiCAJ80302; CAJ80302; FTL_1863.
GeneIDi3950910.
KEGGiftl:FTL_1863.
PATRICi17944980. VBIFraTul90181_2021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM233362 Genomic DNA. Translation: CAJ80302.1.
RefSeqiWP_003017427.1. NC_007880.1.
YP_514480.1. NC_007880.1.

3D structure databases

ProteinModelPortaliQ2A1C2.
SMRiQ2A1C2. Positions 13-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi119857.FTL_1863.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ80302; CAJ80302; FTL_1863.
GeneIDi3950910.
KEGGiftl:FTL_1863.
PATRICi17944980. VBIFraTul90181_2021.

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiFAREPIS.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciFTUL376619:GI22-1913-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain)."
    Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVSImported.

Entry informationi

Entry nameiQ2A1C2_FRATH
AccessioniPrimary (citable) accession number: Q2A1C2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: February 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.