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Q29ZJ1 (LACG_LACRH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phospho-beta-galactosidase

EC=3.2.1.85
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase
Short name=PGALase
P-beta-Gal
Short name=PBG
Gene names
Name:lacG
OrganismLactobacillus rhamnosus
Taxonomic identifier47715 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. HAMAP-Rule MF_01574

Pathway

Carbohydrate metabolism; lactose degradation; D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. HAMAP-Rule MF_01574

Sequence similarities

Belongs to the glycosyl hydrolase 1 family.

Ontologies

Keywords
   Molecular functionGlycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processlactose catabolic process via tagatose-6-phosphate

Inferred from electronic annotation. Source: InterPro

   Molecular_function6-phospho-beta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4744746-phospho-beta-galactosidase HAMAP-Rule MF_01574
PRO_0000260723

Sites

Active site1601Proton donor By similarity
Active site3751Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29ZJ1 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: E115E26364815405

FASTA47453,727
        10         20         30         40         50         60 
MRKQLPKDFV IGGATAAYQV EGATKEDGKG RVLWDDFLEK QGRFSPDPAA DFYHRYDEDL 

        70         80         90        100        110        120 
ALAEAYGHQV IRLSIAWSRI FPDGAGAVEP RGVAFYHRLF AACAKHHLIP FVTLHHFDTP 

       130        140        150        160        170        180 
ERLHAIGDWL SQEMLEDFVE YARFCFEEFP EIKHWITINE PTSMAVQQYT SGTFPPAETG 

       190        200        210        220        230        240 
HFDKTFQAEH NQIVAHARIV NLYKSMGLDG EIGIVHALQT PYPYSDSSED QHAADLQDAL 

       250        260        270        280        290        300 
ENRLYLDGTL AGDYAPKTLA LIKEILAANQ QPMFKYTDEE MAAIKKAAHQ LDFVGVNNYF 

       310        320        330        340        350        360 
SKWLRAYHGK SETIHNGDGS KGSSVARLHG IGEEKKPAGI ETTDWDWSIY PRGMYDMLMR 

       370        380        390        400        410        420 
IHQDYPLVPA IYVTENGIGL KESLPAEVTP NTVIADPKRI DYLKKYLSAV ADAIQAGANV 

       430        440        450        460        470 
KGYFVWSLQD QFSWTNGYSK RYGLFFVDFP TQKRYVKQSA EWLKQVSQTH VIPE 

« Hide

References

[1]"Sequence, organization, transcription and regulation of lactose and galactose operons in Lactobacillus rhamnosus TCELL-1."
Tsai Y.-K., Lin T.-H.
J. Appl. Microbiol. 100:446-459(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: TCELL-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY705915 Genomic DNA. Translation: AAW30155.1.

3D structure databases

ProteinModelPortalQ29ZJ1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00542; UER00605.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
HAMAPMF_01574. LacG.
InterProIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10353. PTHR10353. 1 hit.
PfamPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSPR00131. GLHYDRLASE1.
SUPFAMSSF51445. SSF51445. 1 hit.
TIGRFAMsTIGR01233. lacG. 1 hit.
PROSITEPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLACG_LACRH
AccessionPrimary (citable) accession number: Q29ZJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 4, 2006
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries