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Protein

6-phospho-beta-galactosidase

Gene

lacG

Organism
Lactobacillus rhamnosus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donorUniRule annotation
Active sitei375 – 3751NucleophileUniRule annotation

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00542; UER00605.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidaseUniRule annotation (EC:3.2.1.85UniRule annotation)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolaseUniRule annotation
Short name:
PGALaseUniRule annotation
P-beta-GalUniRule annotation
Short name:
PBGUniRule annotation
Gene namesi
Name:lacGUniRule annotation
OrganismiLactobacillus rhamnosus
Taxonomic identifieri47715 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4744746-phospho-beta-galactosidasePRO_0000260723Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ29ZJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29ZJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKQLPKDFV IGGATAAYQV EGATKEDGKG RVLWDDFLEK QGRFSPDPAA
60 70 80 90 100
DFYHRYDEDL ALAEAYGHQV IRLSIAWSRI FPDGAGAVEP RGVAFYHRLF
110 120 130 140 150
AACAKHHLIP FVTLHHFDTP ERLHAIGDWL SQEMLEDFVE YARFCFEEFP
160 170 180 190 200
EIKHWITINE PTSMAVQQYT SGTFPPAETG HFDKTFQAEH NQIVAHARIV
210 220 230 240 250
NLYKSMGLDG EIGIVHALQT PYPYSDSSED QHAADLQDAL ENRLYLDGTL
260 270 280 290 300
AGDYAPKTLA LIKEILAANQ QPMFKYTDEE MAAIKKAAHQ LDFVGVNNYF
310 320 330 340 350
SKWLRAYHGK SETIHNGDGS KGSSVARLHG IGEEKKPAGI ETTDWDWSIY
360 370 380 390 400
PRGMYDMLMR IHQDYPLVPA IYVTENGIGL KESLPAEVTP NTVIADPKRI
410 420 430 440 450
DYLKKYLSAV ADAIQAGANV KGYFVWSLQD QFSWTNGYSK RYGLFFVDFP
460 470
TQKRYVKQSA EWLKQVSQTH VIPE
Length:474
Mass (Da):53,727
Last modified:April 4, 2006 - v1
Checksum:iE115E26364815405
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY705915 Genomic DNA. Translation: AAW30155.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY705915 Genomic DNA. Translation: AAW30155.1.

3D structure databases

ProteinModelPortaliQ29ZJ1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00542; UER00605.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence, organization, transcription and regulation of lactose and galactose operons in Lactobacillus rhamnosus TCELL-1."
    Tsai Y.-K., Lin T.-H.
    J. Appl. Microbiol. 100:446-459(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: TCELL-1.

Entry informationi

Entry nameiLACG_LACRH
AccessioniPrimary (citable) accession number: Q29ZJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 4, 2006
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.