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Protein

Early growth response protein 1

Gene

EGR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri337 – 36125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 1
Short name:
EGR-1
Gene namesi
Name:EGR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Early growth response protein 1PRO_0000244380Add
BLAST

Proteomic databases

PaxDbiQ29W20.

Interactioni

Subunit structurei

Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013284.

Structurei

3D structure databases

ProteinModelPortaliQ29W20.
SMRiQ29W20. Positions 334-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 8429Gly/Ser-richAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri337 – 36125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG003909.
InParanoidiQ29W20.
KOiK09203.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021839. DUF3432.
IPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11914. DUF3432. 1 hit.
PF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29W20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML SNGAPQFLGA
60 70 80 90 100
AGAPEGSSGS SSGSSGGGGG GGGGSSSSNS NSSSAFNPQG EASEQPYEHL
110 120 130 140 150
TAESFPDISL NNEKVLVETS YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW
160 170 180 190 200
PEPLFSLVSG LVSMTNPPAT SSSASSPAAS SSASQSPPLS CAVQSNDSSP
210 220 230 240 250
IYSAAPTFPT PNTDIFPEPQ GQAFPGSAGP ALQYPPPAYP GAKGGFQVPM
260 270 280 290 300
IPDYLFPQQQ GDLGLGTPDQ KPFQGLESRT QQPSLTPLST IKAFATQSGS
310 320 330 340 350
QDLKALNSTY QSQLIKPSRM RKYPNRPSKT PPHERPYACP VESCDRRFSR
360 370 380 390 400
SDELTRHIRI HTGQKPQCRI SMRNFSRSDH LTTHIRTHTG EKPFACDICG
410 420 430 440 450
RKFARSDERK RHTKIHLRQK DKKADKSAAS AATSSLPSYP SPVATSYPSP
460 470 480 490 500
ATTSYPSPAT TSYPSPVPTS YSSPGSSTYP SPVHNGFPSP SVATTYSSVP
510 520 530 540
PAFPTQVSSF PSSAVTNSFS ASTGLSDMTT TFSPRTIEIC
Length:540
Mass (Da):57,115
Last modified:April 4, 2006 - v1
Checksum:iC16D470B244B34AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY924307 mRNA. Translation: AAY16442.1.
RefSeqiNP_001039340.1. NM_001045875.1.
UniGeneiBt.54463.

Genome annotation databases

GeneIDi407125.
KEGGibta:407125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY924307 mRNA. Translation: AAY16442.1.
RefSeqiNP_001039340.1. NM_001045875.1.
UniGeneiBt.54463.

3D structure databases

ProteinModelPortaliQ29W20.
SMRiQ29W20. Positions 334-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013284.

Proteomic databases

PaxDbiQ29W20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi407125.
KEGGibta:407125.

Organism-specific databases

CTDi1958.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG003909.
InParanoidiQ29W20.
KOiK09203.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021839. DUF3432.
IPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11914. DUF3432. 1 hit.
PF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGR1_BOVIN
AccessioniPrimary (citable) accession number: Q29W20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.