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Protein

Early growth response protein 1

Gene

EGR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri337 – 361C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri366 – 388C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 1
Short name:
EGR-1
Gene namesi
Name:EGR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443801 – 540Early growth response protein 1Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ29W20

Interactioni

Subunit structurei

Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei335Interaction with DNABy similarity1
Sitei346Interaction with DNABy similarity1
Sitei350Interaction with DNABy similarity1
Sitei356Interaction with DNABy similarity1
Sitei373Interaction with DNABy similarity1
Sitei377Interaction with DNABy similarity1
Sitei401Interaction with DNABy similarity1
Sitei405Interaction with DNABy similarity1
Sitei411Interaction with DNABy similarity1

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013284

Structurei

3D structure databases

ProteinModelPortaliQ29W20
SMRiQ29W20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 84Gly/Ser-richAdd BLAST29

Domaini

Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri337 – 361C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri366 – 388C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOVERGENiHBG003909
InParanoidiQ29W20
KOiK09203

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR021839 EGR1_C
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11914 DUF3432, 1 hit
PF11928 DUF3446, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q29W20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML SNGAPQFLGA
60 70 80 90 100
AGAPEGSSGS SSGSSGGGGG GGGGSSSSNS NSSSAFNPQG EASEQPYEHL
110 120 130 140 150
TAESFPDISL NNEKVLVETS YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW
160 170 180 190 200
PEPLFSLVSG LVSMTNPPAT SSSASSPAAS SSASQSPPLS CAVQSNDSSP
210 220 230 240 250
IYSAAPTFPT PNTDIFPEPQ GQAFPGSAGP ALQYPPPAYP GAKGGFQVPM
260 270 280 290 300
IPDYLFPQQQ GDLGLGTPDQ KPFQGLESRT QQPSLTPLST IKAFATQSGS
310 320 330 340 350
QDLKALNSTY QSQLIKPSRM RKYPNRPSKT PPHERPYACP VESCDRRFSR
360 370 380 390 400
SDELTRHIRI HTGQKPQCRI SMRNFSRSDH LTTHIRTHTG EKPFACDICG
410 420 430 440 450
RKFARSDERK RHTKIHLRQK DKKADKSAAS AATSSLPSYP SPVATSYPSP
460 470 480 490 500
ATTSYPSPAT TSYPSPVPTS YSSPGSSTYP SPVHNGFPSP SVATTYSSVP
510 520 530 540
PAFPTQVSSF PSSAVTNSFS ASTGLSDMTT TFSPRTIEIC
Length:540
Mass (Da):57,115
Last modified:April 4, 2006 - v1
Checksum:iC16D470B244B34AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY924307 mRNA Translation: AAY16442.1
RefSeqiNP_001039340.1, NM_001045875.1
UniGeneiBt.54463

Genome annotation databases

GeneIDi407125
KEGGibta:407125

Similar proteinsi

Entry informationi

Entry nameiEGR1_BOVIN
AccessioniPrimary (citable) accession number: Q29W20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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