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Q29ST6

- Q29ST6_DANRE

UniProt

Q29ST6 - Q29ST6_DANRE

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Protein

Adenosine receptor A2

Gene

adora2aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.UniRule annotation

GO - Molecular functioni

  1. G-protein coupled adenosine receptor activity Source: InterPro

GO - Biological processi

  1. heart contraction Source: ZFIN
  2. regulation of cell proliferation involved in tissue homeostasis Source: ZFIN
  3. regulation of type B pancreatic cell proliferation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_208663. Adenosine P1 receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2UniRule annotation
Gene namesi
Name:adora2aaImported
Synonyms:adora2a.1Imported
ORF Names:zgc:194773Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-080723-28. adora2aa.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation, GlycoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043901.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiNOG287824.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
KOiK04266.
OMAiPGVWANG.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29ST6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNNVFDVLY MILELLIALL SVLGNVLVCW AVGLNSNLQS ITNFFVVSLA
60 70 80 90 100
VADIAVGVLA IPFSIVISTG FCANFYGCLF IACFVLVLTQ SSIFSLLAIA
110 120 130 140 150
IDRYIAIKIP LRYNSLVTGQ RARGIIAICW VLSVIIGLTP MLGWHKARLQ
160 170 180 190 200
EGHNGTCPPG MMECLFEEVV VMDYMVYFNF FACVLVPLLL MLAIYLRIFM
210 220 230 240 250
AARHQLKCIE SKAIPCELKS RSTLQKEVHA AKSLAIIVGL FAVCWLPLHI
260 270 280 290 300
INCFTLFCPE CERPPALIMY LAIILSHANS VVNPFIYAYR IREFRHTFRK
310 320 330 340 350
IVRYHILGRR EPLSCNGSTR TSTRTSVADS LRIKVNGLVR ELYAEQSSTT
360 370 380 390 400
SSCESAEPGH THRPVSTENS ILDNQPIEIS NSHRHTALRH PESPLTGNNE
410 420 430 440
GLACRKHAGL DITDGKDLSS PLHIKSALYV QTAHCVELTE VS
Length:442
Mass (Da):49,111
Last modified:April 4, 2006 - v1
Checksum:i8603AF4D797FFAEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR547121 Genomic DNA. No translation available.
CR848681 Genomic DNA. No translation available.
BC163368 mRNA. Translation: AAI63368.1.
BC163378 mRNA. Translation: AAI63378.1.
AY945800 mRNA. Translation: AAX63345.1.
RefSeqiNP_001034904.1. NM_001039815.1.
XP_005167233.1. XM_005167176.1.
UniGeneiDr.79527.

Genome annotation databases

EnsembliENSDART00000043902; ENSDARP00000043901; ENSDARG00000033706.
ENSDART00000138750; ENSDARP00000121566; ENSDARG00000033706.
GeneIDi561701.
KEGGidre:561701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR547121 Genomic DNA. No translation available.
CR848681 Genomic DNA. No translation available.
BC163368 mRNA. Translation: AAI63368.1 .
BC163378 mRNA. Translation: AAI63378.1 .
AY945800 mRNA. Translation: AAX63345.1 .
RefSeqi NP_001034904.1. NM_001039815.1.
XP_005167233.1. XM_005167176.1.
UniGenei Dr.79527.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000043901.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000043902 ; ENSDARP00000043901 ; ENSDARG00000033706 .
ENSDART00000138750 ; ENSDARP00000121566 ; ENSDARG00000033706 .
GeneIDi 561701.
KEGGi dre:561701.

Organism-specific databases

CTDi 561701.
ZFINi ZDB-GENE-080723-28. adora2aa.

Phylogenomic databases

eggNOGi NOG287824.
GeneTreei ENSGT00550000074524.
HOGENOMi HOG000015770.
HOVERGENi HBG106962.
KOi K04266.
OMAi PGVWANG.
OrthoDBi EOG79SDXQ.
TreeFami TF325296.

Enzyme and pathway databases

Reactomei REACT_208663. Adenosine P1 receptors.

Miscellaneous databases

NextBioi 20884057.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Boehmler W.A., Woll M.P., Canfield V.A., Levenson R.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Identification of zebrafish A2 adenosine receptors and expression in developing embryos."
    Boehmler W., Petko J., Woll M., Frey C., Thisse B., Thisse C., Canfield V.A., Levenson R.
    Gene Expr. Patterns 9:144-151(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ29ST6_DANRE
AccessioniPrimary (citable) accession number: Q29ST6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3