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Protein

Adenosine receptor A2

Gene

adora2aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.UniRule annotation

GO - Molecular functioni

  1. G-protein coupled adenosine receptor activity Source: InterPro

GO - Biological processi

  1. heart contraction Source: ZFIN
  2. regulation of cell proliferation involved in tissue homeostasis Source: ZFIN
  3. regulation of type B pancreatic cell proliferation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_208663. Adenosine P1 receptors.
REACT_245767. G alpha (s) signalling events.
REACT_252456. NGF-independant TRKA activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2UniRule annotation
Gene namesi
Name:adora2aaImported
Synonyms:adora2a.1Imported
ORF Names:zgc:194773Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-080723-28. adora2aa.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalUniRule annotationAdd
BLAST
Transmembranei44 – 6724HelicalUniRule annotationAdd
BLAST
Transmembranei73 – 10129HelicalUniRule annotationAdd
BLAST
Transmembranei122 – 14423HelicalUniRule annotationAdd
BLAST
Transmembranei176 – 19621HelicalUniRule annotationAdd
BLAST
Transmembranei234 – 25724HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 28921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation, GlycoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043901.

Structurei

3D structure databases

ProteinModelPortaliQ29ST6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiNOG287824.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
KOiK04266.
OMAiPGVWANG.
OrthoDBiEOG79SDXQ.
PhylomeDBiQ29ST6.
TreeFamiTF325296.

Family and domain databases

InterProiIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29ST6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNNVFDVLY MILELLIALL SVLGNVLVCW AVGLNSNLQS ITNFFVVSLA
60 70 80 90 100
VADIAVGVLA IPFSIVISTG FCANFYGCLF IACFVLVLTQ SSIFSLLAIA
110 120 130 140 150
IDRYIAIKIP LRYNSLVTGQ RARGIIAICW VLSVIIGLTP MLGWHKARLQ
160 170 180 190 200
EGHNGTCPPG MMECLFEEVV VMDYMVYFNF FACVLVPLLL MLAIYLRIFM
210 220 230 240 250
AARHQLKCIE SKAIPCELKS RSTLQKEVHA AKSLAIIVGL FAVCWLPLHI
260 270 280 290 300
INCFTLFCPE CERPPALIMY LAIILSHANS VVNPFIYAYR IREFRHTFRK
310 320 330 340 350
IVRYHILGRR EPLSCNGSTR TSTRTSVADS LRIKVNGLVR ELYAEQSSTT
360 370 380 390 400
SSCESAEPGH THRPVSTENS ILDNQPIEIS NSHRHTALRH PESPLTGNNE
410 420 430 440
GLACRKHAGL DITDGKDLSS PLHIKSALYV QTAHCVELTE VS
Length:442
Mass (Da):49,111
Last modified:April 4, 2006 - v1
Checksum:i8603AF4D797FFAEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR547121 Genomic DNA. No translation available.
CR848681 Genomic DNA. No translation available.
BC163368 mRNA. Translation: AAI63368.1.
BC163378 mRNA. Translation: AAI63378.1.
AY945800 mRNA. Translation: AAX63345.1.
RefSeqiNP_001034904.1. NM_001039815.1.
XP_005167233.1. XM_005167176.2.
UniGeneiDr.79527.

Genome annotation databases

EnsembliENSDART00000043902; ENSDARP00000043901; ENSDARG00000033706.
ENSDART00000138750; ENSDARP00000121566; ENSDARG00000033706.
GeneIDi561701.
KEGGidre:561701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR547121 Genomic DNA. No translation available.
CR848681 Genomic DNA. No translation available.
BC163368 mRNA. Translation: AAI63368.1.
BC163378 mRNA. Translation: AAI63378.1.
AY945800 mRNA. Translation: AAX63345.1.
RefSeqiNP_001034904.1. NM_001039815.1.
XP_005167233.1. XM_005167176.2.
UniGeneiDr.79527.

3D structure databases

ProteinModelPortaliQ29ST6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043901.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000043902; ENSDARP00000043901; ENSDARG00000033706.
ENSDART00000138750; ENSDARP00000121566; ENSDARG00000033706.
GeneIDi561701.
KEGGidre:561701.

Organism-specific databases

CTDi561701.
ZFINiZDB-GENE-080723-28. adora2aa.

Phylogenomic databases

eggNOGiNOG287824.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
KOiK04266.
OMAiPGVWANG.
OrthoDBiEOG79SDXQ.
PhylomeDBiQ29ST6.
TreeFamiTF325296.

Enzyme and pathway databases

ReactomeiREACT_208663. Adenosine P1 receptors.
REACT_245767. G alpha (s) signalling events.
REACT_252456. NGF-independant TRKA activation.

Miscellaneous databases

NextBioi20884057.

Family and domain databases

InterProiIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Boehmler W.A., Woll M.P., Canfield V.A., Levenson R.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Identification of zebrafish A2 adenosine receptors and expression in developing embryos."
    Boehmler W., Petko J., Woll M., Frey C., Thisse B., Thisse C., Canfield V.A., Levenson R.
    Gene Expr. Patterns 9:144-151(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ29ST6_DANRE
AccessioniPrimary (citable) accession number: Q29ST6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: February 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.