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Q29ST6

- Q29ST6_DANRE

UniProt

Q29ST6 - Q29ST6_DANRE

Protein

Adenosine receptor A2

Gene

adora2aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.UniRule annotation

    GO - Molecular functioni

    1. G-protein coupled adenosine receptor activity Source: InterPro

    GO - Biological processi

    1. heart contraction Source: ZFIN
    2. regulation of cell proliferation involved in tissue homeostasis Source: ZFIN
    3. regulation of type B pancreatic cell proliferation Source: ZFIN

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_208663. Adenosine P1 receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosine receptor A2UniRule annotation
    Gene namesi
    Name:adora2aaImported
    Synonyms:adora2a.1Imported
    ORF Names:zgc:194773Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 8

    Organism-specific databases

    ZFINiZDB-GENE-080723-28. adora2aa.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondUniRule annotation, GlycoproteinUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000043901.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    eggNOGiNOG287824.
    GeneTreeiENSGT00550000074524.
    HOGENOMiHOG000015770.
    HOVERGENiHBG106962.
    InParanoidiQ29ST6.
    KOiK04266.
    OMAiPGVWANG.
    OrthoDBiEOG79SDXQ.
    TreeFamiTF325296.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001513. Adeno_A2A_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00553. ADENOSINA2AR.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29ST6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNNVFDVLY MILELLIALL SVLGNVLVCW AVGLNSNLQS ITNFFVVSLA    50
    VADIAVGVLA IPFSIVISTG FCANFYGCLF IACFVLVLTQ SSIFSLLAIA 100
    IDRYIAIKIP LRYNSLVTGQ RARGIIAICW VLSVIIGLTP MLGWHKARLQ 150
    EGHNGTCPPG MMECLFEEVV VMDYMVYFNF FACVLVPLLL MLAIYLRIFM 200
    AARHQLKCIE SKAIPCELKS RSTLQKEVHA AKSLAIIVGL FAVCWLPLHI 250
    INCFTLFCPE CERPPALIMY LAIILSHANS VVNPFIYAYR IREFRHTFRK 300
    IVRYHILGRR EPLSCNGSTR TSTRTSVADS LRIKVNGLVR ELYAEQSSTT 350
    SSCESAEPGH THRPVSTENS ILDNQPIEIS NSHRHTALRH PESPLTGNNE 400
    GLACRKHAGL DITDGKDLSS PLHIKSALYV QTAHCVELTE VS 442
    Length:442
    Mass (Da):49,111
    Last modified:April 4, 2006 - v1
    Checksum:i8603AF4D797FFAEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR547121 Genomic DNA. No translation available.
    CR848681 Genomic DNA. No translation available.
    BC163368 mRNA. Translation: AAI63368.1.
    BC163378 mRNA. Translation: AAI63378.1.
    AY945800 mRNA. Translation: AAX63345.1.
    RefSeqiNP_001034904.1. NM_001039815.1.
    XP_005167233.1. XM_005167176.1.
    UniGeneiDr.79527.

    Genome annotation databases

    EnsembliENSDART00000043902; ENSDARP00000043901; ENSDARG00000033706.
    ENSDART00000138750; ENSDARP00000121566; ENSDARG00000033706.
    GeneIDi561701.
    KEGGidre:561701.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR547121 Genomic DNA. No translation available.
    CR848681 Genomic DNA. No translation available.
    BC163368 mRNA. Translation: AAI63368.1 .
    BC163378 mRNA. Translation: AAI63378.1 .
    AY945800 mRNA. Translation: AAX63345.1 .
    RefSeqi NP_001034904.1. NM_001039815.1.
    XP_005167233.1. XM_005167176.1.
    UniGenei Dr.79527.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000043901.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000043902 ; ENSDARP00000043901 ; ENSDARG00000033706 .
    ENSDART00000138750 ; ENSDARP00000121566 ; ENSDARG00000033706 .
    GeneIDi 561701.
    KEGGi dre:561701.

    Organism-specific databases

    CTDi 561701.
    ZFINi ZDB-GENE-080723-28. adora2aa.

    Phylogenomic databases

    eggNOGi NOG287824.
    GeneTreei ENSGT00550000074524.
    HOGENOMi HOG000015770.
    HOVERGENi HBG106962.
    InParanoidi Q29ST6.
    KOi K04266.
    OMAi PGVWANG.
    OrthoDBi EOG79SDXQ.
    TreeFami TF325296.

    Enzyme and pathway databases

    Reactomei REACT_208663. Adenosine P1 receptors.

    Miscellaneous databases

    NextBioi 20884057.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001513. Adeno_A2A_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00553. ADENOSINA2AR.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Boehmler W.A., Woll M.P., Canfield V.A., Levenson R.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Identification of zebrafish A2 adenosine receptors and expression in developing embryos."
      Boehmler W., Petko J., Woll M., Frey C., Thisse B., Thisse C., Canfield V.A., Levenson R.
      Gene Expr. Patterns 9:144-151(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    5. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiQ29ST6_DANRE
    AccessioniPrimary (citable) accession number: Q29ST6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3