Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type II cytoskeletal 7

Gene

KRT7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei344 – 3441StutterSequence analysis

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 7
Alternative name(s):
Cytokeratin-7
Short name:
CK-7
Keratin-7
Short name:
K7
Type-II keratin Kb7
Gene namesi
Name:KRT7Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 466465Keratin, type II cytoskeletal 7PRO_0000307634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei20 – 201Dimethylated arginine; alternateBy similarity
Modified residuei20 – 201Omega-N-methylarginine; alternateBy similarity
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei98 – 981PhosphothreonineBy similarity
Cross-linki131 – 131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei180 – 1801N6-acetyllysineBy similarity
Modified residuei255 – 2551PhosphoserineBy similarity
Modified residuei290 – 2901PhosphothreonineBy similarity

Post-translational modificationi

Arg-20 is dimethylated, probably to asymmetric dimethylarginine.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ29S21.
PeptideAtlasiQ29S21.
PRIDEiQ29S21.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10. Interacts with GPER1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021516.

Structurei

3D structure databases

ProteinModelPortaliQ29S21.
SMRiQ29S21. Positions 91-127, 358-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 9190HeadSequence analysisAdd
BLAST
Regioni91 – 12737Coil 1ASequence analysisAdd
BLAST
Regioni92 – 400309RodSequence analysisAdd
BLAST
Regioni128 – 14518Linker 1Sequence analysisAdd
BLAST
Regioni146 – 23792Coil 1BSequence analysisAdd
BLAST
Regioni238 – 26124Linker 12Sequence analysisAdd
BLAST
Regioni262 – 400139Coil 2Sequence analysisAdd
BLAST
Regioni401 – 46666TailSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ29S21.
KOiK07605.
OMAiPGIFEAQ.
OrthoDBiEOG7FV3Q8.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29S21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLHFGSQVF SSRSAAFPGR GTQVRLSSVR PGGFGSSSSL YGLGASRPRV
60 70 80 90 100
AARSSYGAPV GTGIRAVTIN QSLLTPLQVD IDPSIQQVRQ EEREQIKTLN
110 120 130 140 150
NKFASFIDKV RFLEQQNKLL ETKWALLQEQ KSAKSNRLPG IFEAQIAGLR
160 170 180 190 200
KQLEALQLDG GRLEVELRNM QDVVEDFKNK YEDEINHRTA AENEFVVLKK
210 220 230 240 250
DVDVAYMNKV ELEAKVDTLN DEINFLRTLY EQELKELQSE VSDTSVVLSM
260 270 280 290 300
DNNRSLDLDS IIAEVKAQYE EIANRSRAEA EACYQTKFET LQAQAGKHGD
310 320 330 340 350
DLQNTRNEIA DMNRAVQRLQ AEIDSVKNQR SKLEAAIADA EQRGELAVKD
360 370 380 390 400
ARAKQEDLEA ALQKAKQDMT RQLREYQELM NVKLALDIEI ATYRKLLEGE
410 420 430 440 450
ESRLTGDGVG AVNISVVSST GGSGSLLTFG GTMGNNALRF SSGGGPGTLK
460
AYSMRTTSAT SRSPRK
Length:466
Mass (Da):51,578
Last modified:April 4, 2006 - v1
Checksum:i4663001F60907BBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113214 mRNA. Translation: AAI13215.1.
RefSeqiNP_001039876.1. NM_001046411.1.
UniGeneiBt.29236.

Genome annotation databases

EnsembliENSBTAT00000021516; ENSBTAP00000021516; ENSBTAG00000016165.
GeneIDi535697.
KEGGibta:535697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113214 mRNA. Translation: AAI13215.1.
RefSeqiNP_001039876.1. NM_001046411.1.
UniGeneiBt.29236.

3D structure databases

ProteinModelPortaliQ29S21.
SMRiQ29S21. Positions 91-127, 358-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021516.

Proteomic databases

PaxDbiQ29S21.
PeptideAtlasiQ29S21.
PRIDEiQ29S21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021516; ENSBTAP00000021516; ENSBTAG00000016165.
GeneIDi535697.
KEGGibta:535697.

Organism-specific databases

CTDi3855.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ29S21.
KOiK07605.
OMAiPGIFEAQ.
OrthoDBiEOG7FV3Q8.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: HerefordImported.
    Tissue: UterusImported.

Entry informationi

Entry nameiK2C7_BOVIN
AccessioniPrimary (citable) accession number: Q29S21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 4, 2006
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.