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Protein

Keratin, type II cytoskeletal 7

Gene

KRT7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei344StutterSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-6805567. Keratinization.
R-BTA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 7
Alternative name(s):
Cytokeratin-7
Short name:
CK-7
Keratin-7
Short name:
K7
Type-II keratin Kb7
Gene namesi
Name:KRT7Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003076342 – 466Keratin, type II cytoskeletal 7Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei20Dimethylated arginine; alternateBy similarity1
Modified residuei20Omega-N-methylarginine; alternateBy similarity1
Modified residuei54PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei98PhosphothreonineBy similarity1
Cross-linki131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei180N6-acetyllysineBy similarity1
Modified residuei255PhosphoserineBy similarity1
Modified residuei290PhosphothreonineBy similarity1

Post-translational modificationi

Arg-20 is dimethylated, probably to asymmetric dimethylarginine.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ29S21.
PeptideAtlasiQ29S21.
PRIDEiQ29S21.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016165.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10. Interacts with GPER1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021516.

Structurei

3D structure databases

ProteinModelPortaliQ29S21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 91HeadSequence analysisAdd BLAST90
Regioni91 – 127Coil 1ASequence analysisAdd BLAST37
Regioni92 – 400RodSequence analysisAdd BLAST309
Regioni128 – 145Linker 1Sequence analysisAdd BLAST18
Regioni146 – 237Coil 1BSequence analysisAdd BLAST92
Regioni238 – 261Linker 12Sequence analysisAdd BLAST24
Regioni262 – 400Coil 2Sequence analysisAdd BLAST139
Regioni401 – 466TailSequence analysisAdd BLAST66

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ29S21.
KOiK07605.
OMAiPGIFEAQ.
OrthoDBiEOG091G09KR.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29S21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLHFGSQVF SSRSAAFPGR GTQVRLSSVR PGGFGSSSSL YGLGASRPRV
60 70 80 90 100
AARSSYGAPV GTGIRAVTIN QSLLTPLQVD IDPSIQQVRQ EEREQIKTLN
110 120 130 140 150
NKFASFIDKV RFLEQQNKLL ETKWALLQEQ KSAKSNRLPG IFEAQIAGLR
160 170 180 190 200
KQLEALQLDG GRLEVELRNM QDVVEDFKNK YEDEINHRTA AENEFVVLKK
210 220 230 240 250
DVDVAYMNKV ELEAKVDTLN DEINFLRTLY EQELKELQSE VSDTSVVLSM
260 270 280 290 300
DNNRSLDLDS IIAEVKAQYE EIANRSRAEA EACYQTKFET LQAQAGKHGD
310 320 330 340 350
DLQNTRNEIA DMNRAVQRLQ AEIDSVKNQR SKLEAAIADA EQRGELAVKD
360 370 380 390 400
ARAKQEDLEA ALQKAKQDMT RQLREYQELM NVKLALDIEI ATYRKLLEGE
410 420 430 440 450
ESRLTGDGVG AVNISVVSST GGSGSLLTFG GTMGNNALRF SSGGGPGTLK
460
AYSMRTTSAT SRSPRK
Length:466
Mass (Da):51,578
Last modified:April 4, 2006 - v1
Checksum:i4663001F60907BBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113214 mRNA. Translation: AAI13215.1.
RefSeqiNP_001039876.1. NM_001046411.1.
UniGeneiBt.29236.

Genome annotation databases

EnsembliENSBTAT00000021516; ENSBTAP00000021516; ENSBTAG00000016165.
GeneIDi535697.
KEGGibta:535697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113214 mRNA. Translation: AAI13215.1.
RefSeqiNP_001039876.1. NM_001046411.1.
UniGeneiBt.29236.

3D structure databases

ProteinModelPortaliQ29S21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021516.

Proteomic databases

PaxDbiQ29S21.
PeptideAtlasiQ29S21.
PRIDEiQ29S21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021516; ENSBTAP00000021516; ENSBTAG00000016165.
GeneIDi535697.
KEGGibta:535697.

Organism-specific databases

CTDi3855.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ29S21.
KOiK07605.
OMAiPGIFEAQ.
OrthoDBiEOG091G09KR.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiR-BTA-6805567. Keratinization.
R-BTA-6809371. Formation of the cornified envelope.

Gene expression databases

BgeeiENSBTAG00000016165.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C7_BOVIN
AccessioniPrimary (citable) accession number: Q29S21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.