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Protein

Pre-miRNA 5'-monophosphate methyltransferase

Gene

BCDIN3D

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-miRNA 5'-monophosphate methyltransferase (EC:2.1.1.-)
Alternative name(s):
BCDIN3 domain-containing protein
Gene namesi
Name:BCDIN3D
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Pre-miRNA 5'-monophosphate methyltransferasePRO_0000289264Add
BLAST

Proteomic databases

PaxDbiQ29S19.
PRIDEiQ29S19.

Interactioni

Subunit structurei

Interacts with DICER1; the interaction may be mediated by RNA.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023645.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 274222Bin3-type SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated
Contains 1 Bin3-type SAM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2899. Eukaryota.
ENOG410XZ7T. LUCA.
GeneTreeiENSGT00390000014918.
HOGENOMiHOG000013152.
HOVERGENiHBG057674.
InParanoidiQ29S19.
OMAiDVGCNCG.
OrthoDBiEOG715Q5R.
TreeFamiTF324061.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR010675. Bin3_C.
IPR024160. BIN3_SAM-bd_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF06859. Bin3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51515. BIN3_SAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29S19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTEQATG GVEKTAAEEK PRVLEPGAAP FGNFPHYSRF HPPEQRLRLL
60 70 80 90 100
PPELLRRLFP QSPETRPILG LDVGCNSGDL SVALYKHFLS LHDGETCLDA
110 120 130 140 150
SRELHLLCCD IDPVLVERAE KECPFPDGLT FITLDFMNQR TRKVLLSSFL
160 170 180 190 200
SQFGRSVFDI GFCMSVTMWI HLNHGDQGLW EFLAHLSSLC RYLLVEPQPW
210 220 230 240 250
KCYRAAARRL RKLGLHDFDH FRSLAIRGDM ASQIVQILTQ DHGMELVCCF
260 270 280 290
GNTKWDRSLL LFRTKQATET HPIPESLIEE GKERNRIRFW RE
Length:292
Mass (Da):33,490
Last modified:April 4, 2006 - v1
Checksum:i570600352C1CA6A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113219 mRNA. Translation: AAI13220.1.
RefSeqiNP_001068684.1. NM_001075216.1.
UniGeneiBt.11290.

Genome annotation databases

EnsembliENSBTAT00000023645; ENSBTAP00000023645; ENSBTAG00000017781.
GeneIDi505650.
KEGGibta:505650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113219 mRNA. Translation: AAI13220.1.
RefSeqiNP_001068684.1. NM_001075216.1.
UniGeneiBt.11290.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023645.

Proteomic databases

PaxDbiQ29S19.
PRIDEiQ29S19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023645; ENSBTAP00000023645; ENSBTAG00000017781.
GeneIDi505650.
KEGGibta:505650.

Organism-specific databases

CTDi144233.

Phylogenomic databases

eggNOGiKOG2899. Eukaryota.
ENOG410XZ7T. LUCA.
GeneTreeiENSGT00390000014918.
HOGENOMiHOG000013152.
HOVERGENiHBG057674.
InParanoidiQ29S19.
OMAiDVGCNCG.
OrthoDBiEOG715Q5R.
TreeFamiTF324061.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR010675. Bin3_C.
IPR024160. BIN3_SAM-bd_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF06859. Bin3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51515. BIN3_SAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiBN3D2_BOVIN
AccessioniPrimary (citable) accession number: Q29S19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 4, 2006
Last modified: June 8, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.