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Q29RY9

- NPL_BOVIN

UniProt

Q29RY9 - NPL_BOVIN

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Protein
N-acetylneuraminate lyase
Gene
NPL
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway By similarity.

Catalytic activityi

N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei143 – 1431Involved in proton transfer during cleavage By similarity
Active sitei173 – 1731Schiff-base intermediate with substrate By similarity

GO - Molecular functioni

  1. N-acetylneuraminate lyase activity Source: UniProtKB

GO - Biological processi

  1. N-acetylneuraminate catabolic process Source: UniProtKB-UniPathway
  2. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiREACT_213420. Sialic acid metabolism.
UniPathwayiUPA00629.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylneuraminate lyase (EC:4.1.3.3)
Short name:
NALase
Alternative name(s):
N-acetylneuraminate pyruvate-lyase
N-acetylneuraminic acid aldolase
Sialate lyase
Sialate-pyruvate lyase
Sialic acid aldolase
Sialic acid lyase
Gene namesi
Name:NPL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 16

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320N-acetylneuraminate lyase
PRO_0000273351Add
BLAST

Proteomic databases

PRIDEiQ29RY9.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002925.

Structurei

3D structure databases

ProteinModelPortaliQ29RY9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 522Substrate binding By similarity

Sequence similaritiesi

Belongs to the DapA family. NanA subfamily.

Phylogenomic databases

eggNOGiCOG0329.
GeneTreeiENSGT00530000063604.
HOGENOMiHOG000218206.
HOVERGENiHBG082055.
InParanoidiQ29RY9.
KOiK01639.
OMAiLKPWNKD.
OrthoDBiEOG7NKKKP.
TreeFamiTF353639.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.

Sequencei

Sequence statusi: Complete.

Q29RY9-1 [UniParc]FASTAAdd to Basket

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MASPKKKLQG LVAATITPMT EHGEINFSVI GRYVDYLVEE QGVKNVFVNG    50
TTGEGLSLSI SERCQVAEEW VTKGKNKLDQ IVIHVGALSL KESQELAQHA 100
AEIGADGIAV IAPFFLKPWN KDVLINFLKE VAAAAPALPF YYYHIPALTG 150
VKIRAEELLD GIQDKIPSFQ GLKFSDTDLL DFGQCVDQNR QRQFAFLFGV 200
DEQLLSALVM GATGAVGSTY NYLGKKTKQM LEAFERKDFS SALNHQFCIQ 250
RFINFVVKLG FGVSQTKAIM TLVSGIPMGP PRLPLQKASR EFTDNAEAKL 300
KSLDFLSCTD LKDGNMEACS 320
Length:320
Mass (Da):35,166
Last modified:April 4, 2006 - v1
Checksum:iD91F221361E56BA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC113332 mRNA. Translation: AAI13333.1.
RefSeqiNP_001039443.1. NM_001045978.1.
XP_005217334.1. XM_005217277.1.
XP_005217335.1. XM_005217278.1.
UniGeneiBt.26155.

Genome annotation databases

EnsembliENSBTAT00000002925; ENSBTAP00000002925; ENSBTAG00000002266.
GeneIDi507597.
KEGGibta:507597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC113332 mRNA. Translation: AAI13333.1 .
RefSeqi NP_001039443.1. NM_001045978.1.
XP_005217334.1. XM_005217277.1.
XP_005217335.1. XM_005217278.1.
UniGenei Bt.26155.

3D structure databases

ProteinModelPortali Q29RY9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000002925.

Proteomic databases

PRIDEi Q29RY9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000002925 ; ENSBTAP00000002925 ; ENSBTAG00000002266 .
GeneIDi 507597.
KEGGi bta:507597.

Organism-specific databases

CTDi 80896.

Phylogenomic databases

eggNOGi COG0329.
GeneTreei ENSGT00530000063604.
HOGENOMi HOG000218206.
HOVERGENi HBG082055.
InParanoidi Q29RY9.
KOi K01639.
OMAi LKPWNKD.
OrthoDBi EOG7NKKKP.
TreeFami TF353639.

Enzyme and pathway databases

UniPathwayi UPA00629 .
Reactomei REACT_213420. Sialic acid metabolism.

Miscellaneous databases

NextBioi 20868136.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view ]
PANTHERi PTHR12128. PTHR12128. 1 hit.
Pfami PF00701. DHDPS. 1 hit.
[Graphical view ]
PIRSFi PIRSF001365. DHDPS. 1 hit.
PRINTSi PR00146. DHPICSNTHASE.
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiNPL_BOVIN
AccessioniPrimary (citable) accession number: Q29RY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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