Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AP-4 complex subunit mu-1

Gene

AP4M1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-432720. Lysosome Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-4 complex subunit mu-1
Alternative name(s):
AP-4 adaptor complex mu subunit
Adaptor-related protein complex 4 subunit mu-1
Mu subunit of AP-4
Mu-adaptin-related protein 2
Short name:
mu-ARP2
Mu4-adaptin
Short name:
mu4
Gene namesi
Name:AP4M1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

  • Golgi apparatustrans-Golgi network By similarity
  • Endosome By similarity

  • Note: Found in soma and dendritic shafts of neuronal cells.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452AP-4 complex subunit mu-1PRO_0000283803Add
BLAST

Proteomic databases

PaxDbiQ29RY8.
PRIDEiQ29RY8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002881.

Interactioni

Subunit structurei

Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with the C-terminal domain of GRID2. Interacts with tyrosine-based sorting signals on the cytoplasmic tail of cargo proteins, such as LAMP2 and APP (By similarity). Interacts with NAGPA.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003736.

Structurei

3D structure databases

ProteinModelPortaliQ29RY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini184 – 451268MHDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000173245.
HOVERGENiHBG102734.
InParanoidiQ29RY8.
KOiK12402.
OMAiQTTSMEM.
OrthoDBiEOG091G0ISV.
TreeFamiTF329745.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29RY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH
60 70 80 90 100
HDDRHFIHIR HSGLYLVATT SENISPFSLL ELLSRLATLL GDYCGSLGEA
110 120 130 140 150
TISRNVALVY ELLDEVLDYG YVQTTSTEVL RNFIQTEAVV SKPFSLFDLS
160 170 180 190 200
SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD QSQKNEVFLD VVERLSVLIA
210 220 230 240 250
SNGSLLKVDV QGEIRLKSFL PSGSEMRIGL TEEFCVGKSE LRGYGPGIRV
260 270 280 290 300
DEVSFHSSVY LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP
310 320 330 340 350
SVQWDRGSGR LQVYLKLRCD LPPKSQALNV RLHLPLPRGV VSLSQELSSP
360 370 380 390 400
EQKAELGEGA LRWDLPRVQG GSQLSGLFQM DVPGLPGPPG QGPSASAPLG
410 420 430 440 450
LGPASLSFEL PRHTCSGLQV RFLRLAFRPC GNANPHKWVR HLSHSDAYVI

RI
Length:452
Mass (Da):49,854
Last modified:April 4, 2006 - v1
Checksum:i2B48FDEACA6E65A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113334 mRNA. Translation: AAI13335.1.
RefSeqiNP_001070567.1. NM_001077099.1.
UniGeneiBt.59228.

Genome annotation databases

EnsembliENSBTAT00000003736; ENSBTAP00000003736; ENSBTAG00000002881.
GeneIDi768040.
KEGGibta:768040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113334 mRNA. Translation: AAI13335.1.
RefSeqiNP_001070567.1. NM_001077099.1.
UniGeneiBt.59228.

3D structure databases

ProteinModelPortaliQ29RY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003736.

Proteomic databases

PaxDbiQ29RY8.
PRIDEiQ29RY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003736; ENSBTAP00000003736; ENSBTAG00000002881.
GeneIDi768040.
KEGGibta:768040.

Organism-specific databases

CTDi9179.

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000173245.
HOVERGENiHBG102734.
InParanoidiQ29RY8.
KOiK12402.
OMAiQTTSMEM.
OrthoDBiEOG091G0ISV.
TreeFamiTF329745.

Enzyme and pathway databases

ReactomeiR-BTA-432720. Lysosome Vesicle Biogenesis.

Gene expression databases

BgeeiENSBTAG00000002881.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP4M1_BOVIN
AccessioniPrimary (citable) accession number: Q29RY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 4, 2006
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.