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Q29RV1

- PDIA4_BOVIN

UniProt

Q29RV1 - PDIA4_BOVIN

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Protein

Protein disulfide-isomerase A4

Gene
PDIA4
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A4 (EC:5.3.4.1)
Gene namesi
Name:PDIA4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Endoplasmic reticulum lumen By similarity. Melanosome By similarity

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. melanosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 643623Protein disulfide-isomerase A4PRO_0000240338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 93Redox-active By similarity
Disulfide bondi205 ↔ 208Redox-active By similarity
Modified residuei365 – 3651N6-acetyllysine By similarity
Disulfide bondi553 ↔ 556Redox-active By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiQ29RV1.
PRIDEiQ29RV1.

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Protein-protein interaction databases

IntActiQ29RV1. 1 interaction.
STRINGi9913.ENSBTAP00000022782.

Structurei

3D structure databases

ProteinModelPortaliQ29RV1.
SMRiQ29RV1. Positions 55-283, 521-643.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 168148Thioredoxin 1Add
BLAST
Domaini170 – 300131Thioredoxin 2Add
BLAST
Domaini503 – 634132Thioredoxin 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi640 – 6434Prevents secretion from ER By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 5416Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 3 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000162459.
HOVERGENiHBG005920.
InParanoidiQ29RV1.
KOiK09582.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR017068. Protein_diS-isomerase_A4.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
PIRSFiPIRSF036862. Disulphide_isom_A4. 1 hit.
SUPFAMiSSF52833. SSF52833. 5 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 3 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29RV1-1 [UniParc]FASTAAdd to Basket

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MRPRKAWMLV LLLALVQLLA VASAGAPDED STDKEDAIEE DEEEDEDDDD    50
DDDDLEVKEE NGVLILNDAN FDNFVADKDT VLLEFYAPWC GHCKQFAPEY 100
EKIAATLKEN DPPIPVAKID ATSESALASR FDVSGYPTIK ILKKGQEVDY 150
EGSRTQEEIV AKVKEVSQPN WTPPPEVTLV LTKDNFDEVV NDADIILVEF 200
YAPWCGHCKK LAPEYEKAAK ELSKSSPPIP LAKVDAIAET DLAKRFDVSS 250
YPTLKIFRKG KAFSYNGPRE KYGIVDYMME QSGPPSKQIL ALKQVQEFLK 300
DGDDVIIIGV FKSESDPAYQ LYQDAANSLR EDYKFHHTFS TEIAKFLKVS 350
LGKLVVMQPE KFQSKYEPKS YVMDIKDSTE AAAITEHVVK HTLPLVGHRK 400
AADAKRYTRR PLVVVYYSVD FSFDYRAATQ FWRNKVLEVA KDFPEYTFAV 450
ADEEDFATEL KDLGLSESGE EVNAAILDEG GRRFAMEPDD FDADALRDFV 500
TAFKKGKLKP VIKSQPVPKN NKGPVKVVVG KTFDSIVMDP KKDVLIEFYA 550
PWCGHCKQLE PVYTSLGKKY KGHKNLVIAK MDATANDVTS DRYKVEGFPT 600
IYFAPSGDKK KPIKFEDGNR DLEHLSKFIE EHATKLSRTK EEL 643
Length:643
Mass (Da):72,526
Last modified:April 4, 2006 - v1
Checksum:iEFBBB755DE97A35E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161V → A in ABG81434. 1 Publication
Sequence conflicti32 – 321T → S in ABG81434. 1 Publication
Sequence conflicti32 – 321T → S in ABQ12930. 1 Publication
Sequence conflicti415 – 4151V → I in ABG81434. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114004 mRNA. Translation: AAI14005.1.
BT026278 mRNA. Translation: ABG81434.1.
BT030490 mRNA. Translation: ABQ12930.1.
RefSeqiNP_001039344.1. NM_001045879.2.
UniGeneiBt.23128.

Genome annotation databases

GeneIDi415110.
KEGGibta:415110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114004 mRNA. Translation: AAI14005.1 .
BT026278 mRNA. Translation: ABG81434.1 .
BT030490 mRNA. Translation: ABQ12930.1 .
RefSeqi NP_001039344.1. NM_001045879.2.
UniGenei Bt.23128.

3D structure databases

ProteinModelPortali Q29RV1.
SMRi Q29RV1. Positions 55-283, 521-643.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q29RV1. 1 interaction.
STRINGi 9913.ENSBTAP00000022782.

Proteomic databases

PaxDbi Q29RV1.
PRIDEi Q29RV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 415110.
KEGGi bta:415110.

Organism-specific databases

CTDi 9601.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000162459.
HOVERGENi HBG005920.
InParanoidi Q29RV1.
KOi K09582.

Miscellaneous databases

NextBioi 20818794.

Family and domain databases

Gene3Di 3.40.30.10. 4 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR017068. Protein_diS-isomerase_A4.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 3 hits.
[Graphical view ]
PIRSFi PIRSF036862. Disulphide_isom_A4. 1 hit.
SUPFAMi SSF52833. SSF52833. 5 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 3 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-478.

Entry informationi

Entry nameiPDIA4_BOVIN
AccessioniPrimary (citable) accession number: Q29RV1
Secondary accession number(s): A5D971, Q0V8E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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