Reviewed,
UniProtKB/Swiss-Prot Q29RV1 (PDIA4_BOVIN)
Last modified
June 16, 2009.
Version 33.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein disulfide-isomerase A4 EC=5.3.4.1 | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 643 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Catalyzes the rearrangement of -S-S- bonds in proteins. |
| Subunit structure | Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. |
| Subcellular location | Endoplasmic reticulum lumen By similarity. Melanosome By similarity. |
| Sequence similarities | Belongs to the protein disulfide isomerase family. Contains 3 thioredoxin domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum |
| Domain | Redox-active center Repeat Signal |
| Molecular function | Isomerase |
| PTM | Disulfide bond |
| Gene Ontology (GO) | |
| Biological process | cell redox homeostasis Inferred from electronic annotation. Source: InterPro |
| Cellular component | endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum lumenInferred from electronic annotation. Source: UniProtKB-SubCell melanosomeInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro protein disulfide isomerase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | ||||||||
| Chain | 21 – 643 | 623 | Protein disulfide-isomerase A4 | PRO_0000240338 | |||||||
Regions | |||||||||||
| Domain | 21 – 168 | 148 | Thioredoxin 1 | ||||||||
| Domain | 170 – 300 | 131 | Thioredoxin 2 | ||||||||
| Domain | 503 – 634 | 132 | Thioredoxin 3 | ||||||||
| Motif | 640 – 643 | 4 | Prevents secretion from ER By similarity | ||||||||
| Compositional bias | 39 – 54 | 16 | Asp/Glu-rich (acidic) | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 90 ↔ 93 | Redox-active By similarity | |||||||||
| Disulfide bond | 205 ↔ 208 | Redox-active By similarity | |||||||||
| Disulfide bond | 553 ↔ 556 | Redox-active By similarity | |||||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| BC114004 mRNA. Translation: AAI14005.1. | |
| IPI | IPI00706136. |
| RefSeq | NP_001039344.1. |
| UniGene | Bt.23128 |
3D structure databases | |
| SMR | Q29RV1. Positions 55-178, 177-283, 521-643. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000017143. Bos taurus. [Contig view] |
| GeneID | 415110. |
| KEGG | bta:415110. |
Phylogenomic databases | |
| HOVERGEN | Q29RV1. |
Enzyme and pathway databases | |
| BRENDA | 5.3.4.1. 251. |
Family and domain databases | |
| InterPro | IPR005788. Disulphide_isomerase. IPR000886. ER_targeting_sequence. IPR005792. Prot_disulphide_isomerase. IPR017068. Protein_diS-isomerase_A4. IPR017936. Thioredoxin-like. IPR006662. Thioredoxin-like_subdom. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 3 hits. |
| Pfam | PF00085. Thioredoxin. 3 hits. [Graphical view] |
| PIRSF | PIRSF036862. Disulphide_isom_A4. 1 hit. |
| PRINTS | PR00421. THIOREDOXIN. |
| TIGRFAMs | TIGR01130. ER_PDI_fam. 1 hit. TIGR01126. pdi_dom. 3 hits. |
| PROSITE | PS00014. ER_TARGET. 1 hit. PS00194. THIOREDOXIN_1. 3 hits. PS51352. THIOREDOXIN_2. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PDIA4_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q29RV1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


