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Q29RV1

- PDIA4_BOVIN

UniProt

Q29RV1 - PDIA4_BOVIN

Protein

Protein disulfide-isomerase A4

Gene

PDIA4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide-isomerase A4 (EC:5.3.4.1)
    Gene namesi
    Name:PDIA4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation. Melanosome By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. melanosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 643623Protein disulfide-isomerase A4PRO_0000240338Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi90 ↔ 93Redox-activePROSITE-ProRule annotation
    Disulfide bondi205 ↔ 208Redox-activePROSITE-ProRule annotation
    Modified residuei365 – 3651N6-acetyllysineBy similarity
    Disulfide bondi553 ↔ 556Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Acetylation, Disulfide bond

    Proteomic databases

    PaxDbiQ29RV1.
    PRIDEiQ29RV1.

    Interactioni

    Subunit structurei

    Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

    Protein-protein interaction databases

    IntActiQ29RV1. 1 interaction.
    STRINGi9913.ENSBTAP00000022782.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29RV1.
    SMRiQ29RV1. Positions 55-283, 521-643.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 168148Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini170 – 300131Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini503 – 634132Thioredoxin 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi640 – 6434Prevents secretion from ERPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi39 – 5416Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 3 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000162459.
    HOVERGENiHBG005920.
    InParanoidiQ29RV1.
    KOiK09582.

    Family and domain databases

    Gene3Di3.40.30.10. 4 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR017068. Protein_diS-isomerase_A4.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 3 hits.
    [Graphical view]
    PIRSFiPIRSF036862. Disulphide_isom_A4. 1 hit.
    SUPFAMiSSF52833. SSF52833. 5 hits.
    TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 3 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 3 hits.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q29RV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPRKAWMLV LLLALVQLLA VASAGAPDED STDKEDAIEE DEEEDEDDDD    50
    DDDDLEVKEE NGVLILNDAN FDNFVADKDT VLLEFYAPWC GHCKQFAPEY 100
    EKIAATLKEN DPPIPVAKID ATSESALASR FDVSGYPTIK ILKKGQEVDY 150
    EGSRTQEEIV AKVKEVSQPN WTPPPEVTLV LTKDNFDEVV NDADIILVEF 200
    YAPWCGHCKK LAPEYEKAAK ELSKSSPPIP LAKVDAIAET DLAKRFDVSS 250
    YPTLKIFRKG KAFSYNGPRE KYGIVDYMME QSGPPSKQIL ALKQVQEFLK 300
    DGDDVIIIGV FKSESDPAYQ LYQDAANSLR EDYKFHHTFS TEIAKFLKVS 350
    LGKLVVMQPE KFQSKYEPKS YVMDIKDSTE AAAITEHVVK HTLPLVGHRK 400
    AADAKRYTRR PLVVVYYSVD FSFDYRAATQ FWRNKVLEVA KDFPEYTFAV 450
    ADEEDFATEL KDLGLSESGE EVNAAILDEG GRRFAMEPDD FDADALRDFV 500
    TAFKKGKLKP VIKSQPVPKN NKGPVKVVVG KTFDSIVMDP KKDVLIEFYA 550
    PWCGHCKQLE PVYTSLGKKY KGHKNLVIAK MDATANDVTS DRYKVEGFPT 600
    IYFAPSGDKK KPIKFEDGNR DLEHLSKFIE EHATKLSRTK EEL 643
    Length:643
    Mass (Da):72,526
    Last modified:April 4, 2006 - v1
    Checksum:iEFBBB755DE97A35E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161V → A in ABG81434. (PubMed:16305752)Curated
    Sequence conflicti32 – 321T → S in ABG81434. (PubMed:16305752)Curated
    Sequence conflicti32 – 321T → S in ABQ12930. (PubMed:16305752)Curated
    Sequence conflicti415 – 4151V → I in ABG81434. (PubMed:16305752)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114004 mRNA. Translation: AAI14005.1.
    BT026278 mRNA. Translation: ABG81434.1.
    BT030490 mRNA. Translation: ABQ12930.1.
    RefSeqiNP_001039344.1. NM_001045879.2.
    UniGeneiBt.23128.

    Genome annotation databases

    GeneIDi415110.
    KEGGibta:415110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114004 mRNA. Translation: AAI14005.1 .
    BT026278 mRNA. Translation: ABG81434.1 .
    BT030490 mRNA. Translation: ABQ12930.1 .
    RefSeqi NP_001039344.1. NM_001045879.2.
    UniGenei Bt.23128.

    3D structure databases

    ProteinModelPortali Q29RV1.
    SMRi Q29RV1. Positions 55-283, 521-643.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q29RV1. 1 interaction.
    STRINGi 9913.ENSBTAP00000022782.

    Proteomic databases

    PaxDbi Q29RV1.
    PRIDEi Q29RV1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 415110.
    KEGGi bta:415110.

    Organism-specific databases

    CTDi 9601.

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000162459.
    HOVERGENi HBG005920.
    InParanoidi Q29RV1.
    KOi K09582.

    Miscellaneous databases

    NextBioi 20818794.

    Family and domain databases

    Gene3Di 3.40.30.10. 4 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR017068. Protein_diS-isomerase_A4.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF036862. Disulphide_isom_A4. 1 hit.
    SUPFAMi SSF52833. SSF52833. 5 hits.
    TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 3 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 3 hits.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-478.

    Entry informationi

    Entry nameiPDIA4_BOVIN
    AccessioniPrimary (citable) accession number: Q29RV1
    Secondary accession number(s): A5D971, Q0V8E1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3