ID   SOX_BOVIN               Reviewed;         392 AA.
AC   Q29RU9; Q5E9H6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Peroxisomal sarcosine oxidase;
DE            Short=PSO;
DE            EC=1.5.3.1;
DE            EC=1.5.3.7;
DE   AltName: Full=L-pipecolate oxidase;
DE   AltName: Full=L-pipecolic acid oxidase;
GN   Name=PIPOX;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Metabolizes sarcosine, L-pipecolic acid and L-proline
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Sarcosine + H(2)O + O(2) = glycine +
CC       formaldehyde + H(2)O(2).
CC   -!- CATALYTIC ACTIVITY: L-pipecolate + O(2) = 2,3,4,5-
CC       tetrahydropyridine-2-carboxylate + H(2)O(2).
CC   -!- COFACTOR: Binds 1 FAD per subunit (By similarity).
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Peroxisome (By similarity).
CC   -!- SIMILARITY: Belongs to the MSOX/MTOX family.
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DR   EMBL; BT020944; AAX08961.1; -; mRNA.
DR   EMBL; BC114006; AAI14007.1; -; mRNA.
DR   IPI; IPI00718597; -.
DR   RefSeq; NP_001014878.2; -.
DR   UniGene; Bt.38917; -.
DR   Ensembl; ENSBTAG00000007946; Bos taurus.
DR   GeneID; 509102; -.
DR   KEGG; bta:509102; -.
DR   HOVERGEN; Q29RU9; -.
DR   BRENDA; 1.5.3.1; 251.
DR   BRENDA; 1.5.3.7; 251.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0050031; F:L-pipecolate oxidase activity; IEA:EC.
DR   GO; GO:0008115; F:sarcosine oxidase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0046653; P:tetrahydrofolate metabolic process; IEA:InterPro.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR006281; SoxA_mon.
DR   Pfam; PF01266; DAO; 1.
DR   TIGRFAMs; TIGR01377; soxA_mon; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Oxidoreductase; Peroxisome.
FT   CHAIN         1    392       Peroxisomal sarcosine oxidase.
FT                                /FTId=PRO_0000244375.
FT   NP_BIND       9     39       FAD (Potential).
FT   MOTIF       390    392       Microbody targeting signal (Potential).
FT   MOD_RES     321    321       S-8alpha-FAD cysteine (By similarity).
FT   CONFLICT    161    161       A -> G (in Ref. 2; AAI14007).
SQ   SEQUENCE   392 AA;  43820 MW;  E62446943F200F67 CRC64;
     MAAQRELYDA IVIGAGIQGC FTAYHLAKHS KKVLLLEQFF LPHSRGSSHG QSRIIRRAYP
     EDFYTQMMAE CYSLWAQLEH EAGTQLYRQT GLLLLGMKEN PELKIIQATL SRQGVEHQCL
     SSEELKQRFP NIRLARGEVG LLEVSGGVLY ADKALRALQD AIRQLGGIVH DGEKVVEIKS
     GLPVMVKTTS RSYQAKSLII TAGPWTNRLL RPLGAELPLQ TLRINVCYWQ EKVPGSYSVS
     QAFPCFMGLG LSLAPHHIYG LPSREYPGLM KVCYHHGNNA DPEERDCPAA FSDIQDVHIL
     SGFVRDHLPD LQPEPAVMEH CMYTNTPDGH FVLDRHPKYD NIVIGAGFSG HGFKLSPVVG
     KILYELSMKL TPSYDLTPFR ISRFPSLGKA HL
//