Reviewed, UniProtKB/Swiss-Prot Q29RU9 (SOX_BOVIN)

Names and origin

Protein names

Recommended name:
    Peroxisomal sarcosine oxidase
      Short name=PSO
    EC=1.5.3.1
    EC=1.5.3.7
Alternative name(s):
    L-pipecolate oxidase
    L-pipecolic acid oxidase

Gene names

Name:

PIPOX

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Metabolizes sarcosine, L-pipecolic acid and L-proline By similarity.
Catalytic activity	Sarcosine + H(2)O + O(2) = glycine + formaldehyde + H(2)O(2). L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2).
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	PeroxisomeBy similarity.
Sequence similarities	Belongs to the MSOX/MTOX family.

Ontologies

Keywords
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-pipecolate oxidase activity Inferred from electronic annotation. Source: EC sarcosine oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Peroxisomal sarcosine oxidase		PRO_0000244375
Regions
	Nucleotide binding	9 – 39	31	FAD Potential
	Motif	390 – 392	3	Microbody targeting signal Potential
Amino acid modifications
	Modified residue	321	1	S-8alpha-FAD cysteine By similarity
Experimental info
	Sequence conflict	161	1	A → G in AAI14007. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q29RU9-1 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: E62446943F200F67	FASTA	392	43,820
	10 20 30 40 50 60 MAAQRELYDA IVIGAGIQGC FTAYHLAKHS KKVLLLEQFF LPHSRGSSHG QSRIIRRAYP 70 80 90 100 110 120 EDFYTQMMAE CYSLWAQLEH EAGTQLYRQT GLLLLGMKEN PELKIIQATL SRQGVEHQCL 130 140 150 160 170 180 SSEELKQRFP NIRLARGEVG LLEVSGGVLY ADKALRALQD AIRQLGGIVH DGEKVVEIKS 190 200 210 220 230 240 GLPVMVKTTS RSYQAKSLII TAGPWTNRLL RPLGAELPLQ TLRINVCYWQ EKVPGSYSVS 250 260 270 280 290 300 QAFPCFMGLG LSLAPHHIYG LPSREYPGLM KVCYHHGNNA DPEERDCPAA FSDIQDVHIL 310 320 330 340 350 360 SGFVRDHLPD LQPEPAVMEH CMYTNTPDGH FVLDRHPKYD NIVIGAGFSG HGFKLSPVVG 370 380 390 KILYELSMKL TPSYDLTPFR ISRFPSLGKA HL

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT020944 mRNA. Translation: AAX08961.1. BC114006 mRNA. Translation: AAI14007.1.
RefSeq	NP_001014878.2.
UniGene	Bt.38917
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000007946. Bos taurus. [Contig view]
GeneID	509102.
KEGG	bta:509102.
Phylogenomic databases
HOVERGEN	Q29RU9.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR006281. SoxA_mon. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
TIGRFAMs	TIGR01377. soxA_mon. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SOX_BOVIN

Accession

Primary (citable) accession number: Q29RU9
Secondary accession number(s): Q5E9H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	September 5, 2006
Last modified:	November 25, 2008
This is version 20 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)