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Protein

Peroxisomal sarcosine oxidase

Gene

PIPOX

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metabolizes sarcosine, L-pipecolic acid and L-proline.By similarity

Catalytic activityi

Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2.
L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 39FADSequence analysisAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-BTA-71064 Lysine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal sarcosine oxidase (EC:1.5.3.1, EC:1.5.3.7)
Short name:
PSO
Alternative name(s):
L-pipecolate oxidase
L-pipecolic acid oxidase
Gene namesi
Name:PIPOX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:32914 PIPOX

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443751 – 392Peroxisomal sarcosine oxidaseAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126N6-acetyllysineBy similarity1
Modified residuei321S-8alpha-FAD cysteineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ29RU9
PeptideAtlasiQ29RU9
PRIDEiQ29RU9

Expressioni

Gene expression databases

BgeeiENSBTAG00000007946

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010444

Structurei

3D structure databases

ProteinModelPortaliQ29RU9
SMRiQ29RU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi390 – 392Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the MSOX/MTOX family.Curated

Phylogenomic databases

eggNOGiKOG2820 Eukaryota
COG0665 LUCA
GeneTreeiENSGT00390000011000
HOGENOMiHOG000236097
HOVERGENiHBG023161
InParanoidiQ29RU9
KOiK00306
OMAiAHTEVEY
OrthoDBiEOG091G0DNX
TreeFamiTF313837

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR006281 SoxA_mon
PfamiView protein in Pfam
PF01266 DAO, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01377 soxA_mon, 1 hit

Sequencei

Sequence statusi: Complete.

Q29RU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQRELYDA IVIGAGIQGC FTAYHLAKHS KKVLLLEQFF LPHSRGSSHG
60 70 80 90 100
QSRIIRRAYP EDFYTQMMAE CYSLWAQLEH EAGTQLYRQT GLLLLGMKEN
110 120 130 140 150
PELKIIQATL SRQGVEHQCL SSEELKQRFP NIRLARGEVG LLEVSGGVLY
160 170 180 190 200
ADKALRALQD AIRQLGGIVH DGEKVVEIKS GLPVMVKTTS RSYQAKSLII
210 220 230 240 250
TAGPWTNRLL RPLGAELPLQ TLRINVCYWQ EKVPGSYSVS QAFPCFMGLG
260 270 280 290 300
LSLAPHHIYG LPSREYPGLM KVCYHHGNNA DPEERDCPAA FSDIQDVHIL
310 320 330 340 350
SGFVRDHLPD LQPEPAVMEH CMYTNTPDGH FVLDRHPKYD NIVIGAGFSG
360 370 380 390
HGFKLSPVVG KILYELSMKL TPSYDLTPFR ISRFPSLGKA HL
Length:392
Mass (Da):43,820
Last modified:September 5, 2006 - v2
Checksum:iE62446943F200F67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161A → G in AAI14007 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020944 mRNA Translation: AAX08961.1
BC114006 mRNA Translation: AAI14007.1
RefSeqiNP_001014878.2, NM_001014878.2
UniGeneiBt.38917

Genome annotation databases

EnsembliENSBTAT00000010444; ENSBTAP00000010444; ENSBTAG00000007946
GeneIDi509102
KEGGibta:509102

Similar proteinsi

Entry informationi

Entry nameiSOX_BOVIN
AccessioniPrimary (citable) accession number: Q29RU9
Secondary accession number(s): Q5E9H6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health