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Protein

Glucose-6-phosphatase

Gene

G6PC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831SubstrateSequence Analysis
Active sitei119 – 1191Proton donorSequence Analysis
Binding sitei170 – 1701SubstrateSequence Analysis
Active sitei176 – 1761NucleophileBy similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: UniProtKB-EC
  2. phosphate ion binding Source: Ensembl
  3. phosphotransferase activity, alcohol group as acceptor Source: Ensembl

GO - Biological processi

  1. cholesterol homeostasis Source: Ensembl
  2. gluconeogenesis Source: UniProtKB-UniPathway
  3. glucose 6-phosphate metabolic process Source: Ensembl
  4. glucose-6-phosphate transport Source: Ensembl
  5. glucose homeostasis Source: Ensembl
  6. glycogen catabolic process Source: Ensembl
  7. multicellular organism growth Source: Ensembl
  8. regulation of gene expression Source: Ensembl
  9. steroid metabolic process Source: Ensembl
  10. triglyceride metabolic process Source: Ensembl
  11. urate metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

ReactomeiREACT_273832. Glucose transport.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase (EC:3.1.3.9)
Short name:
G-6-Pase
Short name:
G6Pase
Gene namesi
Name:G6PC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828LumenalSequence AnalysisAdd
BLAST
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Topological domaini82 – 11736LumenalSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Topological domaini139 – 1479CytoplasmicSequence Analysis
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Topological domaini169 – 1702LumenalSequence Analysis
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Topological domaini192 – 20918CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence AnalysisAdd
BLAST
Topological domaini231 – 25424LumenalSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Topological domaini276 – 29116CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei292 – 31221HelicalSequence AnalysisAdd
BLAST
Topological domaini313 – 3208LumenalSequence Analysis
Transmembranei321 – 34121HelicalSequence AnalysisAdd
BLAST
Topological domaini342 – 35716CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Glucose-6-phosphatasePRO_0000350564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ29RU6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013436.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi354 – 3574Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82628.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ29RU6.
KOiK01084.
OMAiYLQVNYQ.
OrthoDBiEOG73NG4N.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29RU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKGMNVLHD FGIQSTHYLQ VNYQNSQDWF ILVSVIADLR NAFYVLFPIW
60 70 80 90 100
FHLREAVGIK LLWVAVIGDW LNLVFKWILF GQRPYWWVLD TDYYSNTSAP
110 120 130 140 150
LIKQFPVTCE TGPGSPSGHA MGTAGVYYVM VTSTLSIFRG KKKPTYRFRC
160 170 180 190 200
LNVMLWLGFW VVQLNVCLSR IYLAAHFPHQ VVAGVLSGIA VAETFRHIQS
210 220 230 240 250
IYNASLKKYF LITCFLFSFA IGFYLLLKWL GVDLLWTLEK AKRRCERPEW
260 270 280 290 300
VHIDTTPFAS LLKNLGTLFG LGLALNSSMY RESCKGKLSK WFPFRLSCIV
310 320 330 340 350
ASLVLLHLFD SLKPPSQIEL IFYVLSFCKS AAVPLASVSL IPYCLAWVLG

QPNKKTV
Length:357
Mass (Da):40,827
Last modified:April 3, 2006 - v1
Checksum:iB932F00C8940EFEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114011 mRNA. Translation: AAI14012.1.
RefSeqiNP_001069592.1. NM_001076124.2.
UniGeneiBt.17113.

Genome annotation databases

EnsembliENSBTAT00000013436; ENSBTAP00000013436; ENSBTAG00000010184.
GeneIDi538710.
KEGGibta:538710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114011 mRNA. Translation: AAI14012.1.
RefSeqiNP_001069592.1. NM_001076124.2.
UniGeneiBt.17113.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013436.

Proteomic databases

PRIDEiQ29RU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013436; ENSBTAP00000013436; ENSBTAG00000010184.
GeneIDi538710.
KEGGibta:538710.

Organism-specific databases

CTDi2538.

Phylogenomic databases

eggNOGiNOG82628.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ29RU6.
KOiK01084.
OMAiYLQVNYQ.
OrthoDBiEOG73NG4N.
TreeFamiTF324388.

Enzyme and pathway databases

UniPathwayiUPA00138.
ReactomeiREACT_273832. Glucose transport.

Miscellaneous databases

NextBioi20877533.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiG6PC_BOVIN
AccessioniPrimary (citable) accession number: Q29RU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2008
Last sequence update: April 3, 2006
Last modified: March 31, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.