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Q29RU6

- G6PC_BOVIN

UniProt

Q29RU6 - G6PC_BOVIN

Protein

Glucose-6-phosphatase

Gene

G6PC

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + H2O = D-glucose + phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei83 – 831SubstrateSequence Analysis
    Active sitei119 – 1191Proton donorSequence Analysis
    Binding sitei170 – 1701SubstrateSequence Analysis
    Active sitei176 – 1761NucleophileBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphatase activity Source: UniProtKB-EC
    2. phosphate ion binding Source: Ensembl
    3. phosphotransferase activity, alcohol group as acceptor Source: Ensembl

    GO - Biological processi

    1. cholesterol homeostasis Source: Ensembl
    2. gluconeogenesis Source: UniProtKB-UniPathway
    3. glucose 6-phosphate metabolic process Source: Ensembl
    4. glucose-6-phosphate transport Source: Ensembl
    5. glucose homeostasis Source: Ensembl
    6. glycogen catabolic process Source: Ensembl
    7. multicellular organism growth Source: Ensembl
    8. regulation of gene expression Source: Ensembl
    9. steroid metabolic process Source: Ensembl
    10. triglyceride metabolic process Source: Ensembl
    11. urate metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Gluconeogenesis

    Enzyme and pathway databases

    ReactomeiREACT_204270. Glucose transport.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphatase (EC:3.1.3.9)
    Short name:
    G-6-Pase
    Short name:
    G6Pase
    Gene namesi
    Name:G6PC
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Glucose-6-phosphatasePRO_0000350564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ29RU6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000013436.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828LumenalSequence AnalysisAdd
    BLAST
    Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini82 – 11736LumenalSequence AnalysisAdd
    BLAST
    Topological domaini139 – 1479CytoplasmicSequence Analysis
    Topological domaini169 – 1702LumenalSequence Analysis
    Topological domaini192 – 20918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini231 – 25424LumenalSequence AnalysisAdd
    BLAST
    Topological domaini276 – 29116CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini313 – 3208LumenalSequence Analysis
    Topological domaini342 – 35716CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei321 – 34121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi354 – 3574Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the glucose-6-phosphatase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82628.
    GeneTreeiENSGT00510000046465.
    HOGENOMiHOG000264239.
    HOVERGENiHBG003560.
    InParanoidiQ29RU6.
    KOiK01084.
    OMAiYLQVNYQ.
    OrthoDBiEOG73NG4N.
    TreeFamiTF324388.

    Family and domain databases

    Gene3Di1.20.144.10. 1 hit.
    InterProiIPR016275. Glucose-6-phosphatase.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view]
    PfamiPF01569. PAP2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
    SMARTiSM00014. acidPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48317. SSF48317. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q29RU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKGMNVLHD FGIQSTHYLQ VNYQNSQDWF ILVSVIADLR NAFYVLFPIW    50
    FHLREAVGIK LLWVAVIGDW LNLVFKWILF GQRPYWWVLD TDYYSNTSAP 100
    LIKQFPVTCE TGPGSPSGHA MGTAGVYYVM VTSTLSIFRG KKKPTYRFRC 150
    LNVMLWLGFW VVQLNVCLSR IYLAAHFPHQ VVAGVLSGIA VAETFRHIQS 200
    IYNASLKKYF LITCFLFSFA IGFYLLLKWL GVDLLWTLEK AKRRCERPEW 250
    VHIDTTPFAS LLKNLGTLFG LGLALNSSMY RESCKGKLSK WFPFRLSCIV 300
    ASLVLLHLFD SLKPPSQIEL IFYVLSFCKS AAVPLASVSL IPYCLAWVLG 350
    QPNKKTV 357
    Length:357
    Mass (Da):40,827
    Last modified:April 4, 2006 - v1
    Checksum:iB932F00C8940EFEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114011 mRNA. Translation: AAI14012.1.
    RefSeqiNP_001069592.1. NM_001076124.2.
    UniGeneiBt.17113.

    Genome annotation databases

    EnsembliENSBTAT00000013436; ENSBTAP00000013436; ENSBTAG00000010184.
    GeneIDi538710.
    KEGGibta:538710.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114011 mRNA. Translation: AAI14012.1 .
    RefSeqi NP_001069592.1. NM_001076124.2.
    UniGenei Bt.17113.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000013436.

    Proteomic databases

    PRIDEi Q29RU6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013436 ; ENSBTAP00000013436 ; ENSBTAG00000010184 .
    GeneIDi 538710.
    KEGGi bta:538710.

    Organism-specific databases

    CTDi 2538.

    Phylogenomic databases

    eggNOGi NOG82628.
    GeneTreei ENSGT00510000046465.
    HOGENOMi HOG000264239.
    HOVERGENi HBG003560.
    InParanoidi Q29RU6.
    KOi K01084.
    OMAi YLQVNYQ.
    OrthoDBi EOG73NG4N.
    TreeFami TF324388.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    Reactomei REACT_204270. Glucose transport.

    Miscellaneous databases

    NextBioi 20877533.

    Family and domain databases

    Gene3Di 1.20.144.10. 1 hit.
    InterProi IPR016275. Glucose-6-phosphatase.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view ]
    Pfami PF01569. PAP2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
    SMARTi SM00014. acidPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48317. SSF48317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Testis.

    Entry informationi

    Entry nameiG6PC_BOVIN
    AccessioniPrimary (citable) accession number: Q29RU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 23, 2008
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3