Reviewed, UniProtKB/Swiss-Prot Q29RT8 (LPPR2_BOVIN)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphatase-related protein type 2
    EC=3.1.3.4
Alternative name(s):
    Plasticity-related gene 4 protein
      Short name=PRG-4

Gene names

Name:	LPPR2
Synonyms:	PRG4

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Lipid phosphate phosphatase-related protein type 2		PRO_0000317537
Regions
	Transmembrane	14 – 34	21	Potential
	Transmembrane	66 – 86	21	Potential
	Transmembrane	147 – 167	21	Potential
	Transmembrane	176 – 196	21	Potential
	Transmembrane	203 – 223	21	Potential
	Compositional bias	337 – 345	9	Poly-Gly
Amino acid modifications
	Glycosylation	102	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q29RT8-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 9A5166C408797A44	FASTA	389	41,632
	10 20 30 40 50 60 MAGGRPQLKR SFSIIPCFVF VEILLGELAR AFFPAPPSAV PIIGESTIVS GACCRFSPPL 70 80 90 100 110 120 RRLVRFLGVY SFGLFTTTIF ANAGQVVTGN PTPHFLSVCR PNYTALGCPP PSPDRPGPDR 130 140 150 160 170 180 FVNDQGACAG SPSLVAAARR AFPCKDAALC AYAVTYTAMY VTLVFRVKGS RLVKPSLCLA 190 200 210 220 230 240 LLCPAFLVGV VRVAEYRNHW SDVLAGFLTG AAIATFLVTC VVHNFQSRPP SGRRLSPWED 250 260 270 280 290 300 LSQAPTMDSP LEKLSVAQEP EGCRSHSTPA RLTPSKPQNC ARRGHLIPNC VSSRAPAMCS 310 320 330 340 350 360 SPRVPRPRLR SEPTPLPLPL PLPAPAPSQG PSPSSPGPGG PGGGGSRGRK LLLPTPLLRD 370 380 LYTLSGLYPS PFHRDNFSPY LFASRDHLL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC114023 mRNA. Translation: AAI14024.1.
IPI	IPI00687297.
RefSeq	NP_001039713.1.
UniGene	Bt.10704
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000008192. Bos taurus. [Contig view]
GeneID	520247.
KEGG	bta:520247.
Phylogenomic databases
HOVERGEN	Q29RT8.
Enzyme and pathway databases
BRENDA	3.1.3.4. 251.
Family and domain databases
InterPro	IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPPR2_BOVIN

Accession

Primary (citable) accession number: Q29RT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	April 4, 2006
Last modified:	February 10, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)