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Protein

Kinesin-like protein KIF20A

Gene

KIF20A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi159 – 166ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-68884. Mitotic Telophase/Cytokinesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF20A
Gene namesi
Name:KIF20A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002443762 – 888Kinesin-like protein KIF20AAdd BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei527Phosphoserine; by PLK1By similarity1
Modified residuei531PhosphoserineBy similarity1
Modified residuei667PhosphoserineBy similarity1
Modified residuei683PhosphoserineBy similarity1
Modified residuei823PhosphoserineBy similarity1
Modified residuei855PhosphothreonineBy similarity1
Modified residuei865PhosphoserineBy similarity1
Modified residuei876PhosphoserineBy similarity1
Modified residuei881PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by PLK1 at Ser-527 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ29RT6.
PRIDEiQ29RT6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008758.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011539.

Structurei

3D structure databases

ProteinModelPortaliQ29RT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 506Kinesin motorPROSITE-ProRule annotationAdd BLAST444

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni761 – 888GlobularSequence analysisAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili559 – 587Sequence analysisAdd BLAST29
Coiled coili630 – 760Sequence analysisAdd BLAST131

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0247. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133684.
HOGENOMiHOG000054207.
HOVERGENiHBG052246.
InParanoidiQ29RT6.
KOiK10402.
OMAiPANIRFS.
OrthoDBiEOG091G00AY.
TreeFamiTF105232.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR027326. KIF20A.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PTHR24115:SF352. PTHR24115:SF352. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29RT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGILSPPA GLLSDEEVVV SPMFESTAAD LGSVIRKDLL SDCSVISTSL
60 70 80 90 100
EDKQVPSEDG TEKVKVYLRV RPLLPSELER QEDQGCVCIE NMETLALQAP
110 120 130 140 150
KDSFAQKSNE RGIGQATHRF TFSQIFGPEV GQASFFNLTV KEMVKDVLKG
160 170 180 190 200
QNWLIYTYGV TNSGKTYTIQ GTIKDGGILP RSLALIFNSL QGQLHPTPNL
210 220 230 240 250
KPLFSNEVMW LDSKQIRQEE LKKLALLNGG LQEEELSTSL KKSVYIDSRM
260 270 280 290 300
GTSTSFDSGI AGLSSSSQFP SSSQLDEMSH RWAQPDTVPV SVPADLRFSI
310 320 330 340 350
WISFFEIYNE LLYDLLEPPS QQRKRQTLRL CEDQNGNPYV KDLNWIHVQD
360 370 380 390 400
AEEAWKLLKV GRKNQSFAST HLNQNSSRSH SIFSIRILHL QGEGDIIPKI
410 420 430 440 450
SELSLCDLAG SERCKDQKSG ERLKEAGNIN TSLHTLGRCI AALRQNQQNR
460 470 480 490 500
SKQNLVPFRD SKLTRVFQGF FTGRGRSCMI VNVNPCASTY DETLHVAKFS
510 520 530 540 550
AIASQLVHAP PVQLGFPSIH SFLKEHSLRA SPSLETGAKT DPGLGDDIEN
560 570 580 590 600
EVDISTYGKE ELLQVVEAMK ALLLKERQEK LRLEVQLRDE ICNEMVEQMQ
610 620 630 640 650
QREQWCSEHL DTQKELLEEL YEDKLTILKE SLTSFYQEEL QERDEKIKEL
660 670 680 690 700
EALLQEARQQ QVAHQPSGSE LSLRRSQRLT SVSTQQFHEI KAKLEQCKAE
710 720 730 740 750
LNSTTEELQK YQKMLEPPPS AKPFIVDVDK KLEEGQKNIR LLRTELQKLG
760 770 780 790 800
ESLQSAERAC CHNTGAGKLR QALATCDDIL IKQDQTLAEL QNNMTLVKLD
810 820 830 840 850
LRKKAACIAE QYHTVLKLQG QASTKKRLGA NQENQQPNQQ PPGKKPFLRN
860 870 880
LLPRTPTCQS STDCSPYARI LRSRRSPLLK SGPFGKKY
Length:888
Mass (Da):100,044
Last modified:April 4, 2006 - v1
Checksum:iFD2A2D7083DD4662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114026 mRNA. Translation: AAI14027.1.
RefSeqiNP_001039753.1. NM_001046288.2.
UniGeneiBt.18081.

Genome annotation databases

EnsembliENSBTAT00000011539; ENSBTAP00000011539; ENSBTAG00000008758.
GeneIDi527854.
KEGGibta:527854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114026 mRNA. Translation: AAI14027.1.
RefSeqiNP_001039753.1. NM_001046288.2.
UniGeneiBt.18081.

3D structure databases

ProteinModelPortaliQ29RT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011539.

Proteomic databases

PaxDbiQ29RT6.
PRIDEiQ29RT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011539; ENSBTAP00000011539; ENSBTAG00000008758.
GeneIDi527854.
KEGGibta:527854.

Organism-specific databases

CTDi10112.

Phylogenomic databases

eggNOGiKOG0247. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133684.
HOGENOMiHOG000054207.
HOVERGENiHBG052246.
InParanoidiQ29RT6.
KOiK10402.
OMAiPANIRFS.
OrthoDBiEOG091G00AY.
TreeFamiTF105232.

Enzyme and pathway databases

ReactomeiR-BTA-68884. Mitotic Telophase/Cytokinesis.

Gene expression databases

BgeeiENSBTAG00000008758.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR027326. KIF20A.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PTHR24115:SF352. PTHR24115:SF352. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKI20A_BOVIN
AccessioniPrimary (citable) accession number: Q29RT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.