Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase TRIM9

Gene

TRIM9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 50RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri163 – 212B box-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri224 – 266B box-type 2PROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM9 (EC:2.3.2.27By similarity)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM9Curated
Tripartite motif-containing protein 9
Gene namesi
Name:TRIM9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406081 – 710E3 ubiquitin-protein ligase TRIM9Add BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphothreonineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei53PhosphoserineBy similarity1

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ29RQ5.
PRIDEiQ29RQ5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010103.
ExpressionAtlasiQ29RQ5. baseline.

Interactioni

Subunit structurei

Interacts with SNAP25.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042592.

Structurei

3D structure databases

ProteinModelPortaliQ29RQ5.
SMRiQ29RQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini374 – 432COSPROSITE-ProRule annotationAdd BLAST59
Domaini440 – 535Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST96
Domaini533 – 702B30.2/SPRYPROSITE-ProRule annotationAdd BLAST170

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili273 – 340Sequence analysisAdd BLAST68

Domaini

The coiled coil domain mediates the interaction with the N-terminal t-SNARE domain of SNAP25.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 50RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri163 – 212B box-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri224 – 266B box-type 2PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4367. Eukaryota.
ENOG410XQMV. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000007387.
HOVERGENiHBG062305.
InParanoidiQ29RQ5.
KOiK10649.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
IPR035029. TRIM9.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PANTHERiPTHR24103:SF501. PTHR24103:SF501. 1 hit.
PfamiView protein in Pfam
PF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
SMARTiView protein in SMART
SM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29RQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEMEEELKC PVCGSFYREP IILPCSHNIC QACARNILVQ TPESESPQSR
60 70 80 90 100
RASGSGVSDY DYLDLDKMSL YSEADSGYGS YGGFASAPTT PCQKSPNGVR
110 120 130 140 150
VFPPAMPPPA THLSPALASV PRNSCITCPQ CHRSLILDDR GLRGFPKNRV
160 170 180 190 200
LEGVIDRYQQ SKAAALKCQL CEKAPKEATV MCEQCDVFYC DPCRLRCHPP
210 220 230 240 250
RGPLAKHRLV PPAQGRVSRR LSPRKVSTCT DHELENHSMY CVQCKMPVCY
260 270 280 290 300
QCLEEGKHSS HEVKALGAMW KLHKSQLSQA LNGLSDRAKE AKEFLVQLRN
310 320 330 340 350
MVQQIQENSV EFEACLVAQC DALIDALNRR KAQLLARVNK EHEHKLKVVR
360 370 380 390 400
DQISHCTVKL RQTTGLMEYC LEVIKENDPS GFLQISDALI RRVHLTEDQW
410 420 430 440 450
GKGTLTPRMT TDFDLSLDNS PLLQSIHQLD FVQMKASSPV PATPILQLED
460 470 480 490 500
CCTHNNSATL SWKQPPLSTV PAEGYILELD DGNGGQFREV YVGKETMCTV
510 520 530 540 550
DGLHFNSTYN ARIKAFNKTG VSQYSKTLVL QTSEVAWFAF DPGSAHSDII
560 570 580 590 600
FSNDNLTVTC SSYDDRVVLG KTGFSKGVHY WELTVDRYDN HPDPAFGVAR
610 620 630 640 650
IDVMKDVMLG KDDKAWAMYV DNNRSWFMHN NSHTNRTEGG ITKGATIGVL
660 670 680 690 700
LDFNRKTLTF FINDEQQGPI AFENVEGLFF PAVSLNRNVQ VTLHTGLQVP
710
DFYSSRASIA
Length:710
Mass (Da):79,347
Last modified:April 4, 2006 - v1
Checksum:iE919DCE99DC25F30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114071 mRNA. Translation: AAI14072.1.
RefSeqiNP_001070005.1. NM_001076537.2.
UniGeneiBt.110303.

Genome annotation databases

EnsembliENSBTAT00000013346; ENSBTAP00000013346; ENSBTAG00000010103.
GeneIDi767615.
KEGGibta:767615.

Similar proteinsi

Entry informationi

Entry nameiTRIM9_BOVIN
AccessioniPrimary (citable) accession number: Q29RQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: August 30, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families