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Protein

Complement component C7

Gene

C7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C7
Gene namesi
Name:C7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane attack complex, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 843820Complement component C7PRO_0000254015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361C-linked (Man)By similarity
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi91 ↔ 109By similarity
Disulfide bondi103 ↔ 119By similarity
Disulfide bondi128 ↔ 165By similarity
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Glycosylationi503 – 5031C-linked (Man)By similarity
Glycosylationi506 – 5061C-linked (Man)By similarity
Glycosylationi509 – 5091C-linked (Man)By similarity
Disulfide bondi571 ↔ 613By similarity
Disulfide bondi599 ↔ 626By similarity
Disulfide bondi631 ↔ 673By similarity
Disulfide bondi659 ↔ 688By similarity
Glycosylationi696 – 6961O-linked (GalNAc...)By similarity
Disulfide bondi702 ↔ 713By similarity
Disulfide bondi715 ↔ 750By similarity
Disulfide bondi721 ↔ 743By similarity
Disulfide bondi728 ↔ 763By similarity
Glycosylationi754 – 7541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi773 ↔ 782By similarity
Disulfide bondi776 ↔ 789By similarity
Disulfide bondi791 ↔ 825By similarity
Disulfide bondi797 ↔ 818By similarity
Disulfide bondi805 ↔ 838By similarity

Post-translational modificationi

C7 has 28 disulfide bridges.By similarity
C-, N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ29RQ1.
PRIDEiQ29RQ1.

Interactioni

Subunit structurei

Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes (By similarity). Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047583.

Structurei

3D structure databases

ProteinModelPortaliQ29RQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 8054TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini84 – 12037LDL-receptor class APROSITE-ProRule annotationAdd
BLAST
Domaini124 – 456333MACPFPROSITE-ProRule annotationAdd
BLAST
Domaini457 – 48731EGF-likeAdd
BLAST
Domaini500 – 54950TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini569 – 62860Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini629 – 69062Sushi 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni545 – 61571CCP 1Add
BLAST
Regioni616 – 69378CCP 2Add
BLAST
Regioni695 – 77076Factor I module (FIM) 1Add
BLAST
Regioni771 – 84373Factor I module (FIM) 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi216 – 2194Poly-Ser
Compositional biasi227 – 2326Poly-Ser

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated
Contains 1 EGF-like domain.Curated
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 1 MACPF domain.PROSITE-ProRule annotation
Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation
Contains 2 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
HOGENOMiHOG000111868.
HOVERGENiHBG005367.
InParanoidiQ29RQ1.
KOiK03996.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR003884. FacI_MAC.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 2 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29RQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAITLLFLV GFIGEFQVFS SASSPINCQW GSYAPWSECN GCTKTQTRRR
60 70 80 90 100
SIAVYGQYGG HSCVGSAFET QPCQPTRGCP TEDGCGERFR CFSGQCISKS
110 120 130 140 150
LVCNGDSDCE EDGADEDRCE DAESRPACDK DKPPPNIELT GRGYNALTGQ
160 170 180 190 200
FRNQVLNTKS FGGQCRKVYS GDGRDFYRLS GNILSYTFQV KINNDFNNEF
210 220 230 240 250
YNSTWAYVKE TSTEHSSSSK GRFLFFSSSS SSHGYSSNTN ILTKKKSYQL
260 270 280 290 300
LVLQNTVEVA QFINNNPEFL QLAESFWKEL SYLPSLYDYS AYRRLIDQYG
310 320 330 340 350
THYLQSGSLG GEYKVIFHMD SEKVKKFDFH SEDKRKCASS HFQFLFTSSK
360 370 380 390 400
QKCTTMEEVL KSVSENEGNL LRGVPFVRGG HSGFLAGLSY LDLNNPAGNK
410 420 430 440 450
RRYSQWAGSV PDLPEVIKQK LTPLYELVKE VPCASVKKLY LKRAIEEYLD
460 470 480 490 500
EFDPCHCRPC HNGGMATVQG SQCQCYCKPK TSGVACEQGV LLGDQAGGVD
510 520 530 540 550
GGWNCWSSWG PCVQGKKTRS RQCNNPSPSA GGKSCIGETS ETRQCEDEEL
560 570 580 590 600
EHLRLLEPHC FPLSLVPTKF CSSPPALKDG FVQDEGATFP VGKNIMYTCK
610 620 630 640 650
EGYSLVGDPV ARCGEDLQWL VGNMHCQKIA CVLPALMDGI QSHPHKPFYT
660 670 680 690 700
IGEKVTISCS GGRSLEGPST FLCSSSLKWS PEVKDVQCVQ REAPLTPKVP
710 720 730 740 750
KCQPWEKLQN SRCVCKMPYE CGSSLGVCAR DERSKRILPL TVCKMHVLQC
760 770 780 790 800
QGRNYTVAGR ESCTLPASAE KACGVCPLWE KCDAEGSECV CRAASECEEA
810 820 830 840
GFSVCVEVNG REQTMTECEA GVLRCRGLSI SVTGIRPCVA EAA
Length:843
Mass (Da):93,090
Last modified:April 4, 2006 - v1
Checksum:i7CCC4B1DA34D6A07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114076 mRNA. Translation: AAI14077.1.
RefSeqiNP_001039431.1. NM_001045966.1.
UniGeneiBt.18557.

Genome annotation databases

GeneIDi507339.
KEGGibta:507339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114076 mRNA. Translation: AAI14077.1.
RefSeqiNP_001039431.1. NM_001045966.1.
UniGeneiBt.18557.

3D structure databases

ProteinModelPortaliQ29RQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047583.

Proteomic databases

PaxDbiQ29RQ1.
PRIDEiQ29RQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi507339.
KEGGibta:507339.

Organism-specific databases

CTDi730.

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
HOGENOMiHOG000111868.
HOVERGENiHBG005367.
InParanoidiQ29RQ1.
KOiK03996.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR003884. FacI_MAC.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 2 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiCO7_BOVIN
AccessioniPrimary (citable) accession number: Q29RQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 4, 2006
Last modified: June 8, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.