Q29RP8 (SV421_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase SUV420H1
EC=2.1.1.43

Alternative name(s):
Suppressor of variegation 4-20 homolog 1
Short name=Su(var)4-20 homolog 1
Short name=Suv4-20h1

Gene names

Name:

SUV420H1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subunit structure	Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 By similarity.
Subcellular location	Nucleus. Chromosome By similarity. Note: Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Repressor Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone H4-K20 trimethylation Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone methyltransferase activity (H4-K20 specific) Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Histone-lysine N-methyltransferase SUV420H1		PRO_0000281786
Regions
	Domain	193 – 312	120	SET

Sequences

	Sequence		Length	Mass (Da)
	Q29RP8 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: B793EC4D45BF608C	FASTA	393	44,552
	10 20 30 40 50 60 MKWLGESKNM VVNGRRHGGK LSNDHQQNQS KLQHSGKDNV KAGRNAGERR SSRCNGNSGF 70 80 90 100 110 120 EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM NTSAFPPRSS RHFSKSDSFS 130 140 150 160 170 180 HNNPVRFRPI KGRQEELKEV IERFKKDEHL EKAFKCLTSG EWARHYFLNK NKMQEKLFKE 190 200 210 220 230 240 HVFIYLRMFA TDSGFEILPC NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN 250 260 270 280 290 300 MLLRHGENDF SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG 310 320 330 340 350 360 EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRVGLPA PAPVINSKYG LRETDKRLNR 370 380 390 LKKLGDSSKN SDSQSVSSNT DADTTQGRND ASK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC114079 mRNA. Translation: AAI14080.1.
IPI	IPI00903741.
RefSeq	NP_001070019.1. NM_001076551.2.
UniGene	Bt.30964.
3D structure databases
ProteinModelPortal	Q29RP8.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000001570.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	767828.
KEGG	bta:767828.
Organism-specific databases
CTD	51111.
Phylogenomic databases
eggNOG	NOG325204.
HOVERGEN	HBG106119.
KO	K11429.
Family and domain databases
InterPro	IPR025790. Hist-Lys_N-MTase_Suvar4-20. IPR001214. SET_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20918199.

Entry information

Entry name

SV421_BOVIN

Accession

Primary (citable) accession number: Q29RP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 4, 2006
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program