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Q29RP8 (SV421_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase SUV420H1

EC=2.1.1.43
Alternative name(s):
Suppressor of variegation 4-20 homolog 1
Short name=Su(var)4-20 homolog 1
Short name=Suv4-20h1
Gene names
Name:SUV420H1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subunit structure

Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 By similarity.

Subcellular location

Nucleus. Chromosome By similarity. Note: Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Histone-lysine N-methyltransferase SUV420H1
PRO_0000281786

Regions

Domain193 – 308116SET

Sequences

Sequence LengthMass (Da)Tools
Q29RP8 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: B793EC4D45BF608C

FASTA39344,552
        10         20         30         40         50         60 
MKWLGESKNM VVNGRRHGGK LSNDHQQNQS KLQHSGKDNV KAGRNAGERR SSRCNGNSGF 

        70         80         90        100        110        120 
EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM NTSAFPPRSS RHFSKSDSFS 

       130        140        150        160        170        180 
HNNPVRFRPI KGRQEELKEV IERFKKDEHL EKAFKCLTSG EWARHYFLNK NKMQEKLFKE 

       190        200        210        220        230        240 
HVFIYLRMFA TDSGFEILPC NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN 

       250        260        270        280        290        300 
MLLRHGENDF SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG 

       310        320        330        340        350        360 
EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRVGLPA PAPVINSKYG LRETDKRLNR 

       370        380        390 
LKKLGDSSKN SDSQSVSSNT DADTTQGRND ASK 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Heart ventricle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC114079 mRNA. Translation: AAI14080.1.
RefSeqNP_001070019.1. NM_001076551.2.
UniGeneBt.30964.

3D structure databases

ProteinModelPortalQ29RP8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000001570.

Proteomic databases

PRIDEQ29RP8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID767828.
KEGGbta:767828.

Organism-specific databases

CTD51111.

Phylogenomic databases

eggNOGNOG325204.
HOVERGENHBG106119.
KOK11429.

Family and domain databases

InterProIPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
[Graphical view]
SMARTSM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20918199.

Entry information

Entry nameSV421_BOVIN
AccessionPrimary (citable) accession number: Q29RP8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 4, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families