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Q29RP8

- SV421_BOVIN

UniProt

Q29RP8 - SV421_BOVIN

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Protein
Histone-lysine N-methyltransferase SUV420H1
Gene
SUV420H1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone methyltransferase activity (H4-K20 specific) Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB

GO - Biological processi

  1. histone H4-K20 trimethylation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUV420H1 (EC:2.1.1.43)
Alternative name(s):
Suppressor of variegation 4-20 homolog 1
Short name:
Su(var)4-20 homolog 1
Short name:
Suv4-20h1
Gene namesi
Name:SUV420H1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Nucleus. Chromosome By similarity
Note: Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin By similarity.

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Histone-lysine N-methyltransferase SUV420H1
PRO_0000281786Add
BLAST

Proteomic databases

PRIDEiQ29RP8.

Interactioni

Subunit structurei

Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001570.

Structurei

3D structure databases

ProteinModelPortaliQ29RP8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini193 – 308116SET
Add
BLAST

Sequence similaritiesi

Contains 1 SET domain.

Phylogenomic databases

eggNOGiNOG325204.
HOVERGENiHBG106119.
KOiK11429.

Family and domain databases

InterProiIPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29RP8-1 [UniParc]FASTAAdd to Basket

« Hide

MKWLGESKNM VVNGRRHGGK LSNDHQQNQS KLQHSGKDNV KAGRNAGERR    50
SSRCNGNSGF EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM 100
NTSAFPPRSS RHFSKSDSFS HNNPVRFRPI KGRQEELKEV IERFKKDEHL 150
EKAFKCLTSG EWARHYFLNK NKMQEKLFKE HVFIYLRMFA TDSGFEILPC 200
NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN MLLRHGENDF 250
SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG 300
EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRVGLPA PAPVINSKYG 350
LRETDKRLNR LKKLGDSSKN SDSQSVSSNT DADTTQGRND ASK 393
Length:393
Mass (Da):44,552
Last modified:April 4, 2006 - v1
Checksum:iB793EC4D45BF608C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114079 mRNA. Translation: AAI14080.1.
RefSeqiNP_001070019.1. NM_001076551.2.
UniGeneiBt.30964.

Genome annotation databases

GeneIDi767828.
KEGGibta:767828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114079 mRNA. Translation: AAI14080.1 .
RefSeqi NP_001070019.1. NM_001076551.2.
UniGenei Bt.30964.

3D structure databases

ProteinModelPortali Q29RP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000001570.

Proteomic databases

PRIDEi Q29RP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 767828.
KEGGi bta:767828.

Organism-specific databases

CTDi 51111.

Phylogenomic databases

eggNOGi NOG325204.
HOVERGENi HBG106119.
KOi K11429.

Miscellaneous databases

NextBioi 20918199.

Family and domain databases

InterProi IPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiSV421_BOVIN
AccessioniPrimary (citable) accession number: Q29RP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 4, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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