Reviewed,
UniProtKB/Swiss-Prot Q29RP1 (UBP1_BOVIN)
Last modified
June 16, 2009.
Version 25.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquitin carboxyl-terminal hydrolase 1 EC=3.1.2.15 Alternative name(s): Ubiquitin thioesterase 1 Ubiquitin-specific-processing protease 1 Deubiquitinating enzyme 1 | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 783 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Negative regulator of DNA damage repair. Autocatalytic cleavage of USP1 leads to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis following DNA damage. Regulates ubiquitination of FANCD2 By similarity. UniProtKB O94782 |
| Catalytic activity | Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol. UniProtKB O94782 |
| Subunit structure | Interacts with FANCD2 By similarity. UniProtKB O94782 |
| Subcellular location | Nucleus By similarity. UniProtKB O94782 |
| Post-translational modification | Ubiquitinated; leading to its subsequent proteasomal degradation By similarity. Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. UniProtKB O94782 |
| Sequence similarities | Belongs to the peptidase C19 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair Ubl conjugation pathway |
| Cellular component | Nucleus |
| Molecular function | Hydrolase Protease Thiol protease |
| PTM | Autocatalytic cleavage Phosphoprotein Ubl conjugation |
| Gene Ontology (GO) | |
| Biological process | DNA repair Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-dependent protein catabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 783 | 783 | Ubiquitin carboxyl-terminal hydrolase 1 | PRO_0000306286 | |||||
Sites | |||||||||
| Active site | 90 | 1 | By similarity UniProtKB Q93009 | ||||||
| Active site | 582 | 1 | By similarity UniProtKB Q93009 | ||||||
| Active site | 591 | 1 | By similarity UniProtKB Q93009 | ||||||
| Site | 669 – 670 | 2 | Cleavage; by autolysis By similarity UniProtKB O94782 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 13 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 42 | 1 | Phosphoserine By similarity UniProtKB O94782 | ||||||
| Modified residue | 67 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle. |
Cross-references
Sequence databases | |
|---|---|
| BC114087 mRNA. Translation: AAI14088.1. | |
| IPI | IPI00708651. |
| RefSeq | NP_001039689.1. |
| UniGene | Bt.40485 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | C19.019. |
Genome annotation databases | |
| Ensembl | ENSBTAG00000020451. Bos taurus. [Contig view] |
| GeneID | 516328. |
| KEGG | bta:516328. |
Phylogenomic databases | |
| HOVERGEN | Q29RP1. |
Enzyme and pathway databases | |
| BRENDA | 3.1.2.15. 251. |
Family and domain databases | |
| InterPro | IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view] |
| Pfam | PF00443. UCH. 1 hit. [Graphical view] |
| PROSITE | PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UBP1_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q29RP1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


