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Q29RM9

- RGS4_BOVIN

UniProt

Q29RM9 - RGS4_BOVIN

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Protein
Regulator of G-protein signaling 4
Gene
RGS4
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein By similarity.

GO - Biological processi

  1. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_209033. G alpha (z) signalling events.
REACT_210568. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGS4
Gene namesi
Name:RGS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Regulator of G-protein signaling 4
PRO_0000244458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21S-palmitoyl cysteine By similarity
Lipidationi12 – 121S-palmitoyl cysteine By similarity
Lipidationi95 – 951S-palmitoyl cysteine By similarity

Post-translational modificationi

Palmitoylated on Cys-2 and/or Cys-12 By similarity.
Phosphorylated by cyclic GMP-dependent protein kinase By similarity.

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ29RM9.

Structurei

3D structure databases

ProteinModelPortaliQ29RM9.
SMRiQ29RM9. Positions 51-179.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 178117RGS
Add
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

HOVERGENiHBG013233.
KOiK16449.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29RM9-1 [UniParc]FASTAAdd to Basket

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MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHS KKDKVVICQR    50
VSHEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK 100
IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD 150
EAQRKIFNLM EKDSYRRFLK SRFYLDLVNL SSCGSEKQKG AKSSTDCASL 200
VPQCA 205
Length:205
Mass (Da):23,328
Last modified:April 4, 2006 - v1
Checksum:i47F56C83C9FE84DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114106 mRNA. Translation: AAI14107.1.
RefSeqiNP_001040065.1. NM_001046600.2.
UniGeneiBt.35908.

Genome annotation databases

GeneIDi617437.
KEGGibta:617437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114106 mRNA. Translation: AAI14107.1 .
RefSeqi NP_001040065.1. NM_001046600.2.
UniGenei Bt.35908.

3D structure databases

ProteinModelPortali Q29RM9.
SMRi Q29RM9. Positions 51-179.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q29RM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 617437.
KEGGi bta:617437.

Organism-specific databases

CTDi 5999.

Phylogenomic databases

HOVERGENi HBG013233.
KOi K16449.

Enzyme and pathway databases

Reactomei REACT_209033. G alpha (z) signalling events.
REACT_210568. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 20900665.

Family and domain databases

Gene3Di 1.10.196.10. 1 hit.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiRGS4_BOVIN
AccessioniPrimary (citable) accession number: Q29RM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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