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Q29RM9

- RGS4_BOVIN

UniProt

Q29RM9 - RGS4_BOVIN

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Protein

Regulator of G-protein signaling 4

Gene

RGS4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).By similarity

GO - Biological processi

  1. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_209033. G alpha (z) signalling events.
REACT_210568. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGS4
Gene namesi
Name:RGS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Regulator of G-protein signaling 4PRO_0000244458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21S-palmitoyl cysteineBy similarity
Lipidationi12 – 121S-palmitoyl cysteineBy similarity
Lipidationi95 – 951S-palmitoyl cysteineBy similarity

Post-translational modificationi

Palmitoylated on Cys-2 and/or Cys-12.By similarity
Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ29RM9.

Expressioni

Gene expression databases

ExpressionAtlasiQ29RM9. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ29RM9.
SMRiQ29RM9. Positions 51-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 178117RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG013233.
InParanoidiQ29RM9.
KOiK16449.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29RM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHS KKDKVVICQR
60 70 80 90 100
VSHEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK
110 120 130 140 150
IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD
160 170 180 190 200
EAQRKIFNLM EKDSYRRFLK SRFYLDLVNL SSCGSEKQKG AKSSTDCASL

VPQCA
Length:205
Mass (Da):23,328
Last modified:April 4, 2006 - v1
Checksum:i47F56C83C9FE84DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114106 mRNA. Translation: AAI14107.1.
RefSeqiNP_001040065.1. NM_001046600.2.
UniGeneiBt.35908.

Genome annotation databases

GeneIDi617437.
KEGGibta:617437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114106 mRNA. Translation: AAI14107.1 .
RefSeqi NP_001040065.1. NM_001046600.2.
UniGenei Bt.35908.

3D structure databases

ProteinModelPortali Q29RM9.
SMRi Q29RM9. Positions 51-179.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q29RM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 617437.
KEGGi bta:617437.

Organism-specific databases

CTDi 5999.

Phylogenomic databases

HOVERGENi HBG013233.
InParanoidi Q29RM9.
KOi K16449.

Enzyme and pathway databases

Reactomei REACT_209033. G alpha (z) signalling events.
REACT_210568. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 20900665.

Gene expression databases

ExpressionAtlasi Q29RM9. baseline.

Family and domain databases

Gene3Di 1.10.196.10. 1 hit.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiRGS4_BOVIN
AccessioniPrimary (citable) accession number: Q29RM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3