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Q29RM9

- RGS4_BOVIN

UniProt

Q29RM9 - RGS4_BOVIN

Protein

Regulator of G-protein signaling 4

Gene

RGS4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein By similarity.By similarity

    GO - Biological processi

    1. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_209033. G alpha (z) signalling events.
    REACT_210568. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 4
    Short name:
    RGS4
    Gene namesi
    Name:RGS4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Regulator of G-protein signaling 4PRO_0000244458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21S-palmitoyl cysteineBy similarity
    Lipidationi12 – 121S-palmitoyl cysteineBy similarity
    Lipidationi95 – 951S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Palmitoylated on Cys-2 and/or Cys-12.By similarity
    Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiQ29RM9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29RM9.
    SMRiQ29RM9. Positions 51-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 178117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG013233.
    KOiK16449.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29RM9-1 [UniParc]FASTAAdd to Basket

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    MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHS KKDKVVICQR    50
    VSHEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK 100
    IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD 150
    EAQRKIFNLM EKDSYRRFLK SRFYLDLVNL SSCGSEKQKG AKSSTDCASL 200
    VPQCA 205
    Length:205
    Mass (Da):23,328
    Last modified:April 4, 2006 - v1
    Checksum:i47F56C83C9FE84DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114106 mRNA. Translation: AAI14107.1.
    RefSeqiNP_001040065.1. NM_001046600.2.
    UniGeneiBt.35908.

    Genome annotation databases

    GeneIDi617437.
    KEGGibta:617437.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114106 mRNA. Translation: AAI14107.1 .
    RefSeqi NP_001040065.1. NM_001046600.2.
    UniGenei Bt.35908.

    3D structure databases

    ProteinModelPortali Q29RM9.
    SMRi Q29RM9. Positions 51-179.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q29RM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 617437.
    KEGGi bta:617437.

    Organism-specific databases

    CTDi 5999.

    Phylogenomic databases

    HOVERGENi HBG013233.
    KOi K16449.

    Enzyme and pathway databases

    Reactomei REACT_209033. G alpha (z) signalling events.
    REACT_210568. G alpha (i) signalling events.

    Miscellaneous databases

    NextBioi 20900665.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiRGS4_BOVIN
    AccessioniPrimary (citable) accession number: Q29RM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3