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Q29RM9 (RGS4_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 4

Short name=RGS4
Gene names
Name:RGS4
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein By similarity.

Post-translational modification

Palmitoylated on Cys-2 and/or Cys-12 By similarity.

Phosphorylated by cyclic GMP-dependent protein kinase By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Regulator of G-protein signaling 4
PRO_0000244458

Regions

Domain62 – 178117RGS

Amino acid modifications

Lipidation21S-palmitoyl cysteine By similarity
Lipidation121S-palmitoyl cysteine By similarity
Lipidation951S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q29RM9 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 47F56C83C9FE84DC

FASTA20523,328
        10         20         30         40         50         60 
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHS KKDKVVICQR VSHEEVKKWA 

        70         80         90        100        110        120 
ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS 

       130        140        150        160        170        180 
VQATKEVNLD SCTREETSRN MLEPTITCFD EAQRKIFNLM EKDSYRRFLK SRFYLDLVNL 

       190        200 
SSCGSEKQKG AKSSTDCASL VPQCA 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC114106 mRNA. Translation: AAI14107.1.
RefSeqNP_001040065.1. NM_001046600.2.
UniGeneBt.35908.

3D structure databases

ProteinModelPortalQ29RM9.
SMRQ29RM9. Positions 51-179.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ29RM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID617437.
KEGGbta:617437.

Organism-specific databases

CTD5999.

Phylogenomic databases

HOVERGENHBG013233.
KOK16449.

Family and domain databases

Gene3D1.10.196.10. 1 hit.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20900665.

Entry information

Entry nameRGS4_BOVIN
AccessionPrimary (citable) accession number: Q29RM9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 4, 2006
Last modified: January 22, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families