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Protein

Mitochondrial thiamine pyrophosphate carrier

Gene

SLC25A19

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-BTA-196819 Vitamin B1 (thiamin) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier
Alternative name(s):
Solute carrier family 25 member 19
Gene namesi
Name:SLC25A19
Synonyms:DNC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:34747 SLC25A19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei122 – 142Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei173 – 193Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636271 – 318Mitochondrial thiamine pyrophosphate carrierAdd BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ29RM1
PRIDEiQ29RM1

Expressioni

Gene expression databases

BgeeiENSBTAG00000000202

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000237

Structurei

3D structure databases

ProteinModelPortaliQ29RM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 106Solcar 1Add BLAST94
Repeati116 – 202Solcar 2Add BLAST87
Repeati214 – 309Solcar 3Add BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi241 – 246Substrate recognitionBy similarity6

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752 Eukaryota
ENOG410ZRF1 LUCA
GeneTreeiENSGT00550000074902
HOGENOMiHOG000165726
HOVERGENiHBG105731
InParanoidiQ29RM1
KOiK15108
OMAiEPRVYKT
OrthoDBiEOG091G0FNV
TreeFamiTF313047

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q29RM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGYDPKADD RDISNVEVAV AGSVSGLVTR VLISPLDVIK IRFQLQIERL
60 70 80 90 100
SRSDPNAKYH GILQAGRQIL QEEGPTAFWK GHIPAQLLSI GYGAVQFLSF
110 120 130 140 150
EALTELVHRA SVRDARDFSV HFLCGGLSAC VATLAVHPVD VLRTRFAAQG
160 170 180 190 200
EPRVYKTLRD AVVTMYRTEG PLVFYKGLNP TLIAIFPYAG FQFSIYSSLK
210 220 230 240 250
RAYEWALPAE GKKNGNFKNL LCGSGAGVIS KTLTYPLDLF KKRLQVGGFE
260 270 280 290 300
QARASFGQVR SYKGLLDCAG QVLREEGAQG CFKGLSPSLL KAALSTGLVF
310
FWYELFCNFF HHMRKADS
Length:318
Mass (Da):35,112
Last modified:April 4, 2006 - v1
Checksum:iA9E4A57A27361586
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114115 mRNA Translation: AAI14116.1
RefSeqiNP_001039352.1, NM_001045887.1
XP_005221206.1, XM_005221149.3
XP_010814811.1, XM_010816509.2
XP_015314442.1, XM_015458956.1
XP_015314443.1, XM_015458957.1
UniGeneiBt.44282

Genome annotation databases

EnsembliENSBTAT00000000237; ENSBTAP00000000237; ENSBTAG00000000202
GeneIDi504418
KEGGibta:504418

Similar proteinsi

Entry informationi

Entry nameiTPC_BOVIN
AccessioniPrimary (citable) accession number: Q29RM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 4, 2006
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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