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Protein

Gap junction gamma-2 protein

Gene

GJC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-2 protein
Alternative name(s):
Gap junction alpha-12 protein
Gene namesi
Name:GJC2
Synonyms:GJA12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 78ExtracellularSequence analysisAdd BLAST32
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 214CytoplasmicSequence analysisAdd BLAST115
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 263ExtracellularSequence analysisAdd BLAST28
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 429CytoplasmicSequence analysisAdd BLAST145

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002448761 – 429Gap junction gamma-2 proteinAdd BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei366PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ29RK8.
PRIDEiQ29RK8.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with TJP1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019857.

Structurei

3D structure databases

SMRiQ29RK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi145 – 174Glu-richAdd BLAST30

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3. Eukaryota.
ENOG410Z7PN. LUCA.
HOGENOMiHOG000231126.
HOVERGENiHBG009576.
InParanoidiQ29RK8.
KOiK07619.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29RK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNMSWSFLT RLLEEIHNHS TFVGKVWLTV LVVFRIVLTA VGGESIYSDE
60 70 80 90 100
QTKFTCNTRQ PGCDNVCYDA FAPLSHVRFW VFQIVVISTP SVMYLGYAVH
110 120 130 140 150
RLARASQDER RRASRRRPSR RAPRPPLPLP PPPHPGWPEP ADLGEEEPML
160 170 180 190 200
GLGEEDEDPG VAEGLGEDEE AEDTGAAKGA GGDTKVAGVP GPAGQHDGRR
210 220 230 240 250
RIQREGLMRV YVAQLVARAA FEVAFLVGQY LLYGFEVRPF FACSRQPCPH
260 270 280 290 300
VVDCFVSRPT EKTVFLLVMY VVSCLCLLLN LCEMAHLGLG NAQDAVRGRR
310 320 330 340 350
PLPASPGPMP RPPPCALPAA PSGLACPPDY SLVVRTAEHA RAQDQELASL
360 370 380 390 400
ALQALQDRRA LGDLDSPPGP GLPANARGPP KPGAPASGSG SATSGGTVGG
410 420
QGRQGIKPRM GSEKGSGSSS REGKTTVWI
Length:429
Mass (Da):46,067
Last modified:April 4, 2006 - v1
Checksum:i068C71AFEBBE9E6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114129 mRNA. Translation: AAI14130.1.
RefSeqiNP_001039905.1. NM_001046440.1.
UniGeneiBt.35166.

Genome annotation databases

GeneIDi538745.
KEGGibta:538745.

Similar proteinsi

Entry informationi

Entry nameiCXG2_BOVIN
AccessioniPrimary (citable) accession number: Q29RK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: April 4, 2006
Last modified: May 10, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families