ID   AP4A_BOVIN              Reviewed;         147 AA.
AC   Q29RJ1;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical];
DE            EC=3.6.1.17;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase;
DE            Short=Diadenosine tetraphosphatase;
DE            Short=Ap4A hydrolase;
DE            Short=Ap4Aase;
DE   AltName: Full=Nucleoside diphosphate-linked moiety X motif 2;
DE            Short=Nudix motif 2;
GN   Name=NUDT2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.
CC       Plays a major role in maintaining homeostasis.
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-guanosyl) tetraphosphate +
CC       H(2)O = GTP + GMP.
CC   -!- COFACTOR: Divalent ions (By similarity).
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family.
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DR   EMBL; BC114149; AAI14150.1; -; mRNA.
DR   IPI; IPI00742579; -.
DR   RefSeq; NP_001070570.1; -.
DR   UniGene; Bt.2818; -.
DR   SMR; Q29RJ1; 1-144.
DR   Ensembl; ENSBTAG00000031793; Bos taurus.
DR   GeneID; 768044; -.
DR   KEGG; bta:768044; -.
DR   HOVERGEN; Q29RJ1; -.
DR   OMA; Q29RJ1; HQFLCST.
DR   BRENDA; 3.6.1.17; 251.
DR   GO; GO:0004081; F:bis(5'-nucleosyl)-tetraphosphatase (asymmet...; IEA:EC.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR000086; NUDIX_hydrolase_core.
DR   InterPro; IPR003565; Tetra_PHTase.
DR   Gene3D; G3DSA:3.90.79.10; NUDIX_hydrolase; 1.
DR   Pfam; PF00293; NUDIX; 1.
DR   PRINTS; PR01405; TETRPHPHTASE.
DR   PROSITE; PS00893; NUDIX; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; GTP-binding; Hydrolase; Nucleotide-binding.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    147       Bis(5'-nucleosyl)-tetraphosphatase
FT                                [asymmetrical].
FT                                /FTId=PRO_0000260767.
FT   MOTIF        43     64       Nudix box.
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
SQ   SEQUENCE   147 AA;  16775 MW;  1BC4523DF285D130 CRC64;
     MALRACGLII FRRRLIPKVD NTAIEFLLLQ ASDGIHHWTP PKGHVEPGES DLETALRETQ
     EEAGIEAGQL TIIEGFRREL SYVARAKPKI VIYWLAEVKD CDVEVRLSRE HQAYRWLELE
     DACQLAQFEE MKAALQEGHQ FLCSTAT
//