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Protein

Atypical kinase ADCK3, mitochondrial

Gene

ADCK3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Shows an unusual selectivity for binding ADP over ATP.By similarity

Enzyme regulationi

Autoinhibited by the N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket.By similarity

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei358 – 3581ATPBy similarity
Active sitei488 – 4881Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi336 – 3449ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Atypical kinase ADCK3, mitochondrialCurated (EC:2.7.-.-By similarity)
Alternative name(s):
Chaperone activity of bc1 complex-likeBy similarity
Short name:
Chaperone-ABC1-likeBy similarity
aarF domain-containing protein kinase 3
Gene namesi
Name:ADCK3
Synonyms:CABC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

  • Mitochondrion By similarity
  • Membrane Sequence analysis; Single-pass membrane protein Sequence analysisBy similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei214 – 23017HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 162162MitochondrionBy similarityAdd
BLAST
Chaini163 – 648486Atypical kinase ADCK3, mitochondrialPRO_0000271794Add
BLAST

Proteomic databases

PaxDbiQ29RI0.
PRIDEiQ29RI0.

Interactioni

Subunit structurei

Homodimer; homodimerizes via its transmembrane region.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029167.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini329 – 518190Protein kinaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi276 – 2794KxGQ motifBy similarity
Motifi337 – 3404AAAS motifBy similarity

Domaini

Adopts an atypical protein kinase-like fold: while it adopts a core fold similar to that of well-characterized protein kinase-like domains, a number of features are positioned to inhibit the kinase activity: (1) an atypical AAAS motif in an alanine-rich (A-rich) loop that replaces the canonical glycine-rich (G-rich) nucleotide-binding loop and limits ATP binding by establishing an unusual selectivity for ADP and (2) an N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket.By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1234. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00550000074739.
HOGENOMiHOG000201140.
HOVERGENiHBG061318.
InParanoidiQ29RI0.
KOiK08869.
OMAiYEVKVME.
OrthoDBiEOG7X9G6H.
TreeFamiTF300630.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29RI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMLGDAIM LIKGFVKLTQ AAVETHLQHL GLSGELLMAV RALQSTATEQ
60 70 80 90 100
VGMVFGQVQG QETPEEYYSE SLDDPEGAFH FSGMRAESAS ADVSAASSPE
110 120 130 140 150
QSPPPWAHAA GSEGPAPAYV ASAPFREGGV LGQAASPLGR VNGRLFASPR
160 170 180 190 200
DPFSAPGLQR RVYHQDQSSM GGLTAEDIEK ARQAKARPES KPHKQALSEH
210 220 230 240 250
ARERKVPVTR IGRLANFGGL AVGLGFGALA EVAKKSLRPD DPSGKKAVLD
260 270 280 290 300
SSPFLSEANA ERIVRTLCKV RGAALKLGQM LSIQDDAFIN PHLAKIFDRV
310 320 330 340 350
RQSADFMPLK QMMKTLNNDL GPNWRDKLEY FEERPFAAAS IGQVHLARLK
360 370 380 390 400
GGREVAMKIQ YPGVAQSINS DVNNLMTVLN MSNMLPEGLF PEHLIDVLRR
410 420 430 440 450
ELALECDYQR EAACARRFRE LLKDHPFFYV PEIVDELCSP HVLTTELVSG
460 470 480 490 500
FPLDQAEGLS QEIRNEICYN ILVLCLRELF EFQFMQTDPN WSNFFYDPEL
510 520 530 540 550
HKVALLDFGA TREFDRSFTD LYIQIIRAAA NQDREAVLKK SIEMKFLTGY
560 570 580 590 600
EVKAMEDAHL DAILILGEAF ASEEPFDFGT QSTTEKIHNL IPIMLKHRLV
610 620 630 640
PPPEETYSLH RKMGGSFLIC SKLKARFPCK AMFEEAYSNY CRRQAEQQ
Length:648
Mass (Da):72,082
Last modified:April 4, 2006 - v1
Checksum:i217518E10C95C73D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114164 mRNA. Translation: AAI14165.1.
BT026249 mRNA. Translation: ABG67088.1.
RefSeqiNP_001039884.1. NM_001046419.2.
XP_010811432.1. XM_010813130.2.
UniGeneiBt.22379.

Genome annotation databases

EnsembliENSBTAT00000029167; ENSBTAP00000029167; ENSBTAG00000021880.
GeneIDi536925.
KEGGibta:536925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114164 mRNA. Translation: AAI14165.1.
BT026249 mRNA. Translation: ABG67088.1.
RefSeqiNP_001039884.1. NM_001046419.2.
XP_010811432.1. XM_010813130.2.
UniGeneiBt.22379.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029167.

Proteomic databases

PaxDbiQ29RI0.
PRIDEiQ29RI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029167; ENSBTAP00000029167; ENSBTAG00000021880.
GeneIDi536925.
KEGGibta:536925.

Organism-specific databases

CTDi56997.

Phylogenomic databases

eggNOGiKOG1234. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00550000074739.
HOGENOMiHOG000201140.
HOVERGENiHBG061318.
InParanoidiQ29RI0.
KOiK08869.
OMAiYEVKVME.
OrthoDBiEOG7X9G6H.
TreeFamiTF300630.

Enzyme and pathway databases

UniPathwayiUPA00232.

Miscellaneous databases

NextBioi20877036.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 262-648.

Entry informationi

Entry nameiADCK3_BOVIN
AccessioniPrimary (citable) accession number: Q29RI0
Secondary accession number(s): Q0V8G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 4, 2006
Last modified: April 13, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.