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Protein

Peroxisomal NADH pyrophosphatase NUDT12

Gene

NUDT12

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)+, ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity).By similarity

Catalytic activityi

NAD(H) + H2O = AMP + NMN(H).

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi352Magnesium or manganeseBy similarity1
Metal bindingi356Magnesium or manganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese, Metal-binding, NAD, NADP

Enzyme and pathway databases

ReactomeiR-BTA-197264. Nicotinamide salvaging.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal NADH pyrophosphatase NUDT12 (EC:3.6.1.22)
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 12
Short name:
Nudix motif 12
Gene namesi
Name:NUDT12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002607681 – 444Peroxisomal NADH pyrophosphatase NUDT12Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167N6-succinyllysineBy similarity1
Modified residuei274N6-succinyllysineBy similarity1

Proteomic databases

PaxDbiQ29RH3.
PRIDEiQ29RH3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000027728.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039749.

Structurei

3D structure databases

ProteinModelPortaliQ29RH3.
SMRiQ29RH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 40ANK 1Add BLAST30
Repeati60 – 80ANK 2Add BLAST21
Domaini301 – 435Nudix hydrolasePROSITE-ProRule annotationAdd BLAST135

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi337 – 358Nudix boxAdd BLAST22
Motifi442 – 444Microbody targeting signalBy similarity3

Sequence similaritiesi

Belongs to the Nudix hydrolase family. NudC subfamily.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG3084. Eukaryota.
COG2816. LUCA.
GeneTreeiENSGT00530000063600.
HOVERGENiHBG054394.
InParanoidiQ29RH3.
KOiK03426.
OMAiRSVLAWH.
OrthoDBiEOG091G0SLC.
TreeFamiTF106352.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR036770. Ankyrin_rpt-contain_sf.
IPR015375. NADH_PPase-like_N.
IPR015797. NUDIX_hydrolase-like_dom_sf.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015376. Znr_NADH_PPase.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
PF09296. NUDIX-like. 1 hit.
PF09297. zf-NADH-PPase. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q29RH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVKRSLNQ EIISQFHYSA AEGDIAKLTA ILSHSPSLLN ETSENGWSAL
60 70 80 90 100
ICDRSIVNKS RQTALDIAKF WGYKHIANLL ANAKGGKKPW FLTNEVEECE
110 120 130 140 150
NYFSKTLLDR KSEKRNNSDW LLAKESHPAT VYILFSDLNP LVTLGGNKES
160 170 180 190 200
FQQPEVRLCQ LNYTDIKDYL AQPEKITLIF LGVELEMKKE FFNYAGEISK
210 220 230 240 250
EEEDGLVAWF ALGIDTVAAE EFKQRHENCY FLHPPMPALL QLKEKEAGVV
260 270 280 290 300
AQARSVLAWH SRYKFCPTCG NATKIEEGGY KRVCLKEDCP SLHGVHNTSY
310 320 330 340 350
PRVDPVVIMQ VIHPDGTKCL LGRQKRFPPG MFTCLAGFIE PGETIEDAVR
360 370 380 390 400
REVEEESGVK VGHVQYVSCQ PWPMPSSLMI GCLAVAVSTE IKVDKNEIED
410 420 430 440
ARWFTREQVV DVLTKGKQQA FFVPPSRAIA HQLIKHWIGM NPNL
Length:444
Mass (Da):50,119
Last modified:April 4, 2006 - v1
Checksum:iD9352B6AFCD6F21B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114173 mRNA. Translation: AAI14174.1.
RefSeqiNP_001040073.1. NM_001046608.1.
UniGeneiBt.17805.

Genome annotation databases

EnsembliENSBTAT00000039965; ENSBTAP00000039749; ENSBTAG00000027728.
GeneIDi617720.
KEGGibta:617720.

Similar proteinsi

Entry informationi

Entry nameiNUD12_BOVIN
AccessioniPrimary (citable) accession number: Q29RH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 4, 2006
Last modified: November 22, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families