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Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene

PDS5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA repair Source: GO_Central
  • mitotic sister chromatid cohesion Source: UniProtKB
  • negative regulation of DNA replication Source: UniProtKB
  • sister chromatid cohesion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090308-MONOMER.
ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2468052. Establishment of Sister Chromatid Cohesion.
R-HSA-2470946. Cohesin Loading onto Chromatin.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog A
Alternative name(s):
Cell proliferation-inducing gene 54 protein
Sister chromatid cohesion protein 112
Short name:
SCC-112
Gene namesi
Name:PDS5AImported
Synonyms:KIAA0648Imported, PDS51 Publication
ORF Names:PIG54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29088. PDS5A.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: UniProtKB
  • chromosome Source: Reactome
  • chromosome, centromeric region Source: Reactome
  • cytosol Source: Reactome
  • nucleoplasm Source: HPA
  • nucleus Source: GO_Central
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23244.
OpenTargetsiENSG00000121892.
PharmGKBiPA162399027.

Polymorphism and mutation databases

BioMutaiPDS5A.
DMDMi121947590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002963411 – 1337Sister chromatid cohesion protein PDS5 homolog AAdd BLAST1337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei1097PhosphoserineCombined sources1
Modified residuei1146N6-acetyllysineCombined sources1
Modified residuei1195PhosphoserineCombined sources1
Modified residuei1208PhosphothreonineCombined sources1
Modified residuei1211N6-acetyllysineCombined sources1
Modified residuei1290N6-acetyllysineCombined sources1
Modified residuei1305PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ29RF7.
MaxQBiQ29RF7.
PaxDbiQ29RF7.
PeptideAtlasiQ29RF7.
PRIDEiQ29RF7.

PTM databases

iPTMnetiQ29RF7.
PhosphoSitePlusiQ29RF7.
SwissPalmiQ29RF7.

Expressioni

Tissue specificityi

Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.1 Publication

Developmental stagei

Cell cycle-regulated with highest level in G2 phase.1 Publication

Gene expression databases

BgeeiENSG00000121892.
CleanExiHS_PDS5A.
ExpressionAtlasiQ29RF7. baseline and differential.
GenevisibleiQ29RF7. HS.

Organism-specific databases

HPAiHPA036661.
HPA036662.

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDCA5Q96FF93EBI-1175454,EBI-718805
RAD21O602164EBI-1175454,EBI-80739
SMC3Q9UQE74EBI-1175454,EBI-80718
STAG1Q8WVM73EBI-1175454,EBI-1175097
STAG2Q8N3U43EBI-1175454,EBI-1057252

Protein-protein interaction databases

BioGridi116848. 71 interactors.
DIPiDIP-35419N.
IntActiQ29RF7. 34 interactors.
STRINGi9606.ENSP00000303427.

Structurei

3D structure databases

ProteinModelPortaliQ29RF7.
SMRiQ29RF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati393 – 429HEATSequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the PDS5 family.Curated
Contains 1 HEAT repeat.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1525. Eukaryota.
ENOG410XQW7. LUCA.
GeneTreeiENSGT00390000012488.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.
InParanoidiQ29RF7.
KOiK11267.
OMAiCNAESPK.
OrthoDBiEOG091G00ZG.
PhylomeDBiQ29RF7.
TreeFamiTF106415.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q29RF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFTAQPKPA TALCGVVSAD GKIAYPPGVK EITDKITTDE MIKRLKMVVK
60 70 80 90 100
TFMDMDQDSE DEKQQYLPLA LHLASEFFLR NPNKDVRLLV ACCLADIFRI
110 120 130 140 150
YAPEAPYTSH DKLKDIFLFI TRQLKGLEDT KSPQFNRYFY LLENLAWVKS
160 170 180 190 200
YNICFELEDC NEIFIQLFRT LFSVINNSHN KKVQMHMLDL MSSIIMEGDG
210 220 230 240 250
VTQELLDSIL INLIPAHKNL NKQSFDLAKV LLKRTVQTIE ACIANFFNQV
260 270 280 290 300
LVLGRSSVSD LSEHVFDLIQ ELFAIDPHLL LSVMPQLEFK LKSNDGEERL
310 320 330 340 350
AVVRLLAKLF GSKDSDLATQ NRPLWQCFLG RFNDIHVPVR LESVKFASHC
360 370 380 390 400
LMNHPDLAKD LTEYLKVRSH DPEEAIRHDV IVTIITAAKR DLALVNDQLL
410 420 430 440 450
GFVRERTLDK RWRVRKEAMM GLAQLYKKYC LHGEAGKEAA EKVSWIKDKL
460 470 480 490 500
LHIYYQNSID DKLLVEKIFA QYLVPHNLET EERMKCLYYL YASLDPNAVK
510 520 530 540 550
ALNEMWKCQN MLRSHVRELL DLHKQPTSEA NCSAMFGKLM TIAKNLPDPG
560 570 580 590 600
KAQDFVKKFN QVLGDDEKLR SQLELLISPT CSCKQADICV REIARKLANP
610 620 630 640 650
KQPTNPFLEM VKFLLERIAP VHIDSEAISA LVKLMNKSIE GTADDEEEGV
660 670 680 690 700
SPDTAIRSGL ELLKVLSFTH PTSFHSAETY ESLLQCLRME DDKVAEAAIQ
710 720 730 740 750
IFRNTGHKIE TDLPQIRSTL IPILHQKAKR GTPHQAKQAV HCIHAIFTNK
760 770 780 790 800
EVQLAQIFEP LSRSLNADVP EQLITPLVSL GHISMLAPDQ FASPMKSVVA
810 820 830 840 850
NFIVKDLLMN DRSTGEKNGK LWSPDEEVSP EVLAKVQAIK LLVRWLLGMK
860 870 880 890 900
NNQSKSANST LRLLSAMLVS EGDLTEQKRI SKSDMSRLRL AAGSAIMKLA
910 920 930 940 950
QEPCYHEIIT PEQFQLCALV INDECYQVRQ IFAQKLHKAL VKLLLPLEYM
960 970 980 990 1000
AIFALCAKDP VKERRAHARQ CLLKNISIRR EYIKQNPMAT EKLLSLLPEY
1010 1020 1030 1040 1050
VVPYMIHLLA HDPDFTRSQD VDQLRDIKEC LWFMLEVLMT KNENNSHAFM
1060 1070 1080 1090 1100
KKMAENIKLT RDAQSPDESK TNEKLYTVCD VALCVINSKS ALCNADSPKD
1110 1120 1130 1140 1150
PVLPMKFFTQ PEKDFCNDKS YISEETRVLL LTGKPKPAGV LGAVNKPLSA
1160 1170 1180 1190 1200
TGRKPYVRST GTETGSNINV NSELNPSTGN RSREQSSEAA ETGVSENEEN
1210 1220 1230 1240 1250
PVRIISVTPV KNIDPVKNKE INSDQATQGN ISSDRGKKRT VTAAGAENIQ
1260 1270 1280 1290 1300
QKTDEKVDES GPPAPSKPRR GRRPKSESQG NATKNDDLNK PINKGRKRAA
1310 1320 1330
VGQESPGGLE AGNAKAPKLQ DLAKKAAPAE RQIDLQR
Length:1,337
Mass (Da):150,830
Last modified:April 4, 2006 - v1
Checksum:iFA28EA9EF77499D9
GO
Isoform 2 (identifier: Q29RF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     591-600: REIARKLANP → VSKSYFTLFL
     601-1337: Missing.

Show »
Length:600
Mass (Da):69,000
Checksum:i12917E7912C86BFD
GO

Sequence cautioni

The sequence AAI26226 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM82347 differs from that shown. Probable cloning artifact.Curated
The sequence CAH18263 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207D → G in AAM82347 (PubMed:15019998).Curated1
Sequence conflicti471Q → R in AAT52214 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052491591 – 600REIARKLANP → VSKSYFTLFL in isoform 2. 4 Publications10
Alternative sequenceiVSP_052492601 – 1337Missing in isoform 2. 4 PublicationsAdd BLAST737

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY550968 mRNA. Translation: AAT52214.1.
AK098331 mRNA. Translation: BAC05286.1.
BC041361 mRNA. Translation: AAH41361.1.
BC114218 mRNA. Translation: AAI14219.1.
BC126225 mRNA. Translation: AAI26226.1. Different initiation.
AF294791 mRNA. Translation: AAM82347.1. Sequence problems.
CR749425 mRNA. Translation: CAH18263.1. Different initiation.
AB014548 mRNA. Translation: BAA31623.1.
CCDSiCCDS47045.1. [Q29RF7-1]
CCDS54759.1. [Q29RF7-3]
RefSeqiNP_001093869.1. NM_001100399.1. [Q29RF7-1]
NP_001093870.1. NM_001100400.1. [Q29RF7-3]
XP_011511974.1. XM_011513672.2. [Q29RF7-1]
XP_016863417.1. XM_017007928.1. [Q29RF7-1]
UniGeneiHs.331431.

Genome annotation databases

EnsembliENST00000303538; ENSP00000303427; ENSG00000121892. [Q29RF7-1]
ENST00000503396; ENSP00000426749; ENSG00000121892. [Q29RF7-3]
GeneIDi23244.
KEGGihsa:23244.
UCSCiuc003guv.4. human. [Q29RF7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY550968 mRNA. Translation: AAT52214.1.
AK098331 mRNA. Translation: BAC05286.1.
BC041361 mRNA. Translation: AAH41361.1.
BC114218 mRNA. Translation: AAI14219.1.
BC126225 mRNA. Translation: AAI26226.1. Different initiation.
AF294791 mRNA. Translation: AAM82347.1. Sequence problems.
CR749425 mRNA. Translation: CAH18263.1. Different initiation.
AB014548 mRNA. Translation: BAA31623.1.
CCDSiCCDS47045.1. [Q29RF7-1]
CCDS54759.1. [Q29RF7-3]
RefSeqiNP_001093869.1. NM_001100399.1. [Q29RF7-1]
NP_001093870.1. NM_001100400.1. [Q29RF7-3]
XP_011511974.1. XM_011513672.2. [Q29RF7-1]
XP_016863417.1. XM_017007928.1. [Q29RF7-1]
UniGeneiHs.331431.

3D structure databases

ProteinModelPortaliQ29RF7.
SMRiQ29RF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116848. 71 interactors.
DIPiDIP-35419N.
IntActiQ29RF7. 34 interactors.
STRINGi9606.ENSP00000303427.

PTM databases

iPTMnetiQ29RF7.
PhosphoSitePlusiQ29RF7.
SwissPalmiQ29RF7.

Polymorphism and mutation databases

BioMutaiPDS5A.
DMDMi121947590.

Proteomic databases

EPDiQ29RF7.
MaxQBiQ29RF7.
PaxDbiQ29RF7.
PeptideAtlasiQ29RF7.
PRIDEiQ29RF7.

Protocols and materials databases

DNASUi23244.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303538; ENSP00000303427; ENSG00000121892. [Q29RF7-1]
ENST00000503396; ENSP00000426749; ENSG00000121892. [Q29RF7-3]
GeneIDi23244.
KEGGihsa:23244.
UCSCiuc003guv.4. human. [Q29RF7-1]

Organism-specific databases

CTDi23244.
DisGeNETi23244.
GeneCardsiPDS5A.
HGNCiHGNC:29088. PDS5A.
HPAiHPA036661.
HPA036662.
MIMi613200. gene.
neXtProtiNX_Q29RF7.
OpenTargetsiENSG00000121892.
PharmGKBiPA162399027.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1525. Eukaryota.
ENOG410XQW7. LUCA.
GeneTreeiENSGT00390000012488.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.
InParanoidiQ29RF7.
KOiK11267.
OMAiCNAESPK.
OrthoDBiEOG091G00ZG.
PhylomeDBiQ29RF7.
TreeFamiTF106415.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090308-MONOMER.
ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2468052. Establishment of Sister Chromatid Cohesion.
R-HSA-2470946. Cohesin Loading onto Chromatin.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.

Miscellaneous databases

ChiTaRSiPDS5A. human.
GeneWikiiPDS5A.
GenomeRNAii23244.
PROiQ29RF7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121892.
CleanExiHS_PDS5A.
ExpressionAtlasiQ29RF7. baseline and differential.
GenevisibleiQ29RF7. HS.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPDS5A_HUMAN
AccessioniPrimary (citable) accession number: Q29RF7
Secondary accession number(s): Q2TTR5
, Q68DF7, Q8N7J4, Q8NG14, Q9Y4D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

HeLa cells with a reduced level of PDS5A show a mild defect in sister chromatid cohesion. HeLa cells with a reduced level of RAD21 show reduced association of PDS5A with chromatin.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.