Reviewed, UniProtKB/Swiss-Prot Q29RA5 (TIGRA_DANRE)

Names and origin

Protein names

Recommended name:
    Probable fructose-2,6-bisphosphatase TIGAR A
    EC=3.1.3.46
Alternative name(s):
    TP53-induced glycolysis and apoptosis regulator A

Gene names

Name:	tigara
ORF Names:	zgc:136900

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable fructose-biphosphatase. Lowers cellular levels of fructose 2,6-bisphosphate. Protects cells against reactive oxygen species and against apoptosis induced by tp53 By similarity.
Catalytic activity	Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
Sequence similarities	Belongs to the phosphoglycerate mutase family.
Caution	Not expected to have any kinase activity.

Ontologies

Keywords
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	fructose-2,6-bisphosphate 2-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Probable fructose-2,6-bisphosphatase TIGAR A		PRO_0000363067
Sites
	Active site	11	1	Tele-phosphohistidine intermediate By similarity
	Active site	186	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29RA5-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: E87E233413A199A7	FASTA	256	28,180
	10 20 30 40 50 60 MLAFGLTVVR HGETQCNKDG LLQGQKIDSL LSDIGIQQSE AAGQYLRDVK FTNVFVSNMK 70 80 90 100 110 120 RAKQTAEIIV RNNRTCHDLE LVADPSLIER SFGIAEGGRV IDMKNMAKAA GQPLPEFTPP 130 140 150 160 170 180 EGETMEQVKL RIKDFLKAMY QRIANDHQDK VQDGGTSSAD ESTEAPAGLA NDGVSSVPVH 190 200 210 220 230 240 ALVVGHGAYM SIAMRYFFED LKCPVPRGLD PAQQFSICPN TGMCRFIITL KCSSVDIALS 250 DIKCVFINRR DHFKTN

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC114302 mRNA. Translation: AAI14303.1.
IPI	IPI00742481.
RefSeq	NP_001034925.1.
UniGene	Dr.83996
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSDART00000073420; ENSDARP00000067911; ENSDARG00000051749; Danio rerio. [Genome view] ENSDART00000111158; ENSDARP00000097862; ENSDARG00000051749; Danio rerio. [Genome view]
GeneID	664696.
KEGG	dre:664696.
Organism-specific databases
CTD	664696.
ZFIN	ZDB-GENE-060312-25. tigara.
Phylogenomic databases
HOGENOM	Q29RA5.
HOVERGEN	Q29RA5.
OMA	THGAYMC.
Gene expression databases
Bgee	Q29RA5.
Family and domain databases
InterPro	IPR001345. PG/BPGM_mutase_AC. IPR013078. PG_mutase. [Graphical view]
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TIGRA_DANRE

Accession

Primary (citable) accession number: Q29RA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	April 4, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project