ID   DUPD1_DANRE             Reviewed;         189 AA.
AC   Q29RA3;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Dual specificity phosphatase DUPD1;
DE            EC=3.1.3.48;
DE            EC=3.1.3.16;
GN   Name=dupd1; ORFNames=zgc:136906;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Non-receptor class dual specificity subfamily.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BC114305; AAI14306.1; -; mRNA.
DR   IPI; IPI00742491; -.
DR   RefSeq; NP_001034926.1; -.
DR   UniGene; Dr.94086; -.
DR   HSSP; P51452; 1VHR.
DR   Ensembl; ENSDARG00000068238; Danio rerio.
DR   GeneID; 664697; -.
DR   KEGG; dre:664697; -.
DR   ZFIN; ZDB-GENE-060312-23; zgc:136906.
DR   HOVERGEN; Q29RA3; -.
DR   BRENDA; 3.1.3.16; 96826.
DR   BRENDA; 3.1.3.48; 96826.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphata...; IEA:InterPro.
DR   GO; GO:0006470; P:protein amino acid dephosphorylation; IEA:InterPro.
DR   InterPro; IPR000387; Tyr_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000340; Tyr_Pase_dual_specific.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00195; DSPc; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Protein phosphatase.
FT   CHAIN         1    189       Dual specificity phosphatase DUPD1.
FT                                /FTId=PRO_0000295885.
FT   DOMAIN       33    181       Tyrosine-protein phosphatase.
FT   ACT_SITE    127    127       Phosphocysteine intermediate (By
FT                                similarity).
SQ   SEQUENCE   189 AA;  22004 MW;  336926CEB46074C3 CRC64;
     MSSAQAEDEQ DYETPSCYEL QKHFTHGGVA YTHVNEVWPG VYIGNEETAR DRYKLQTLGI
     THILNAAEGE WNSVDTGAEY YKDMQIHYYG VTAEDTPTFN ISQYFYSAAE YIQQTLSDPH
     NKLLLHCVMG RSRSATLFLA FLMLQQRMSL LQAVEQLAHR RHICPNWGFL KQLRELDTHL
     QEERRRTHT
//