Reviewed, UniProtKB/Swiss-Prot Q29RA3 (DUPD1_DANRE)

Names and origin

Protein names

Recommended name:
    Dual specificity phosphatase DUPD1
    EC=3.1.3.48
    EC=3.1.3.16

Gene names

Name:	dupd1
ORF Names:	zgc:136906

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Dual specificity phosphatase DUPD1		PRO_0000295885
Regions
	Domain	33 – 181	149	Tyrosine-protein phosphatase
Sites
	Active site	127	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29RA3-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 336926CEB46074C3	FASTA	189	22,004
	10 20 30 40 50 60 MSSAQAEDEQ DYETPSCYEL QKHFTHGGVA YTHVNEVWPG VYIGNEETAR DRYKLQTLGI 70 80 90 100 110 120 THILNAAEGE WNSVDTGAEY YKDMQIHYYG VTAEDTPTFN ISQYFYSAAE YIQQTLSDPH 130 140 150 160 170 180 NKLLLHCVMG RSRSATLFLA FLMLQQRMSL LQAVEQLAHR RHICPNWGFL KQLRELDTHL QEERRRTHT

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC114305 mRNA. Translation: AAI14306.1.
IPI	IPI00742491.
RefSeq	NP_001034926.1.
UniGene	Dr.94086
3D structure databases
HSSP	HSSP built from PDB template 1VHR based on UniProtKB P51452.
ModBase	Search...
Genome annotation databases
Ensembl	ENSDARG00000068238. Danio rerio. [Contig view]
GeneID	664697.
KEGG	dre:664697.
Organism-specific databases
ZFIN	ZDB-GENE-060312-23. zgc:136906.
Phylogenomic databases
HOVERGEN	Q29RA3.
Enzyme and pathway databases
BRENDA	3.1.3.16. 96826. 3.1.3.48. 96826.
Family and domain databases
InterPro	IPR000387. Tyr_Pase. IPR016130. Tyr_Pase_AS. IPR000340. Tyr_Pase_dual_specific. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_DANRE

Accession

Primary (citable) accession number: Q29RA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	April 4, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project