Q29RA3 (DUPD1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity phosphatase DUPD1
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:	dupd1
ORF Names:	zgc:136906

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Dual specificity phosphatase DUPD1		PRO_0000295885
Regions
	Domain	33 – 181	149	Tyrosine-protein phosphatase
	Region	126 – 133	8	Substrate binding By similarity
Sites
	Active site	127	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29RA3 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 336926CEB46074C3	FASTA	189	22,004
	10 20 30 40 50 60 MSSAQAEDEQ DYETPSCYEL QKHFTHGGVA YTHVNEVWPG VYIGNEETAR DRYKLQTLGI 70 80 90 100 110 120 THILNAAEGE WNSVDTGAEY YKDMQIHYYG VTAEDTPTFN ISQYFYSAAE YIQQTLSDPH 130 140 150 160 170 180 NKLLLHCVMG RSRSATLFLA FLMLQQRMSL LQAVEQLAHR RHICPNWGFL KQLRELDTHL QEERRRTHT

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC114305 mRNA. Translation: AAI14306.1.
IPI	IPI00742491.
RefSeq	NP_001034926.1. NM_001039837.1.
UniGene	Dr.94086.
3D structure databases
HSSP	HSSP built from PDB template 2ESB based on UniProtKB Q8NEJ0.
ProteinModelPortal	Q29RA3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	664697.
KEGG	dre:664697.
Organism-specific databases
ZFIN	ZDB-GENE-060312-23. zgc:136906.
Phylogenomic databases
eggNOG	NOG314632.
HOVERGEN	HBG001524.
InParanoid	Q29RA3.
KO	K14165.
OrthoDB	EOG4R23W1.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20902313.

Entry information

Entry name

DUPD1_DANRE

Accession

Primary (citable) accession number: Q29RA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	April 4, 2006
Last modified:	March 6, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program