Q29NU5 (GLT25_DROPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycosyltransferase 25 family member
EC=2.-.-.-

Gene names

ORF Names:

GA16561

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › obscura group › pseudoobscura subgroup › Drosophila pseudoobscura

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Endoplasmic reticulum lumen Potential.
Sequence similarities	Belongs to the glycosyltransferase 25 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 626	605	Glycosyltransferase 25 family member		PRO_0000309550
Regions
	Motif	623 – 626	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	113	1	N-linked (GlcNAc...) Potential
	Glycosylation	234	1	N-linked (GlcNAc...) Potential
	Glycosylation	272	1	N-linked (GlcNAc...) Potential
	Glycosylation	533	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q29NU5 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: 85B74CDB5474ECDE	FASTA	626	72,334
	10 20 30 40 50 60 MLKKQVFYGI LLICAFVCIY GEDEDEKEAQ DEYQPPTVLV ALLVRNKAHI LPMFLSYLEQ 70 80 90 100 110 120 QDYPKDRIAF WLRCDHSSDD SIDLLKQWLK HSGDLYHSVN YAFDSDGPHG YQNESSPYDW 130 140 150 160 170 180 TVSRFKHVIA LKEEAFTYAR DIWADFVFFL DADVLLTSQQ ALRTLTALRL PIVAPMLLSE 190 200 210 220 230 240 SLYSNFWCGM TEEYYYQRTD EYKEIYHVKK QGSFPVPMVH TAVLVDMNHK GARNLTFDRQ 250 260 270 280 290 300 RLRDIQQSNQ QLDQPLYEGP ADDIIVFAMS ANSSGIPLHV CNELTFGYIL QPLEPGDTLE 310 320 330 340 350 360 QDLQMLLNIR ASMVSDLGAV PPVLEYFQPL IKTPEKTKLT LDHIFMINLE RRPERRQKME 370 380 390 400 410 420 NLFEEIGLQV EHFPAVDGKE LNADRVQEMG IRFLPGYEDP YHHRAMTMGE IGCFLSHYRI 430 440 450 460 470 480 WVRMVQLELK EVLILEDDIR FDPYFRANAV RVLNQARSVV EYDLIYFGRK RLKEESEPWV 490 500 510 520 530 540 ADADSLVHAG YSYWTLGYVL SLQGALKLLA AKPLEKLIPV DEFLPVMFDR HPNKTWTAAF 550 560 570 580 590 600 KKRDLIALSA APLLLYPIHY TGESGYISDT EDSQQINVQT TEGVARLKSD REQVFVKKGD 610 620 DGILEQQLKM GESLSNVLPG KTHQEL

References

[1]

"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25 / Tucson 14011-0121.94.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH379058 Genomic DNA. Translation: EIM52215.1.
RefSeq	XP_003736142.1. XM_003736094.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0301991; FBpp0291201; FBgn0076576.
GeneID	4818107.
KEGG	dpo:Dpse_GA16561.
Organism-specific databases
FlyBase	FBgn0076576. Dpse\GA16561.
Phylogenomic databases
OMA	YEGADDP.
OrthoDB	EOG4CC2GV.
Family and domain databases
InterPro	IPR002654. Glyco_trans_25. [Graphical view]
Pfam	PF01755. Glyco_transf_25. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLT25_DROPS

Accession

Primary (citable) accession number: Q29NU5
Secondary accession number(s): I5AMN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	April 3, 2013
This is version 36 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project