ID   IMPA3_DROPS             Reviewed;         355 AA.
AC   Q29JH0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   10-FEB-2009, entry version 21.
DE   RecName: Full=Putative inositol monophosphatase 3;
DE            EC=3.1.3.25;
DE   AltName: Full=Inositol-1(or 4)-monophosphatase 3;
DE            Short=IMPase 3;
DE            Short=IMP 3;
DE   AltName: Full=Myo-inositol monophosphatase A3;
GN   ORFNames=GA13929;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- CATALYTIC ACTIVITY: Myo-inositol phosphate + H(2)O = myo-inositol
CC       + phosphate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-
CC       inositol from D-glucose 6-phosphate: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the inositol monophosphatase family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL32331.2; Type=Erroneous gene model prediction;
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CH379063; EAL32331.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001355274.2; -.
DR   GeneID; 4815471; -.
DR   KEGG; dpo:Dpse_GA13929; -.
DR   FlyBase; FBgn0073961; Dpse\GA13929.
DR   BRENDA; 3.1.3.25; 190795.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008934; F:inositol-1(or 4)-monophosphatase activity; ISS:UniProtKB.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006796; P:phosphate metabolic process; ISS:UniProtKB.
DR   GO; GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
DR   InterPro; IPR000760; Inositol_P.
DR   PANTHER; PTHR20854; Inositol_P; 1.
DR   Pfam; PF00459; Inositol_P; 1.
DR   PRINTS; PR00378; INOSPHPHTASE.
DR   PROSITE; PS00629; IMP_1; FALSE_NEG.
DR   PROSITE; PS00630; IMP_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Magnesium; Membrane; Metal-binding;
KW   Transmembrane.
FT   CHAIN         1    355       Putative inositol monophosphatase 3.
FT                                /FTId=PRO_0000289047.
FT   TRANSMEM     16     36       Potential.
FT   METAL       127    127       Magnesium 1 (By similarity).
FT   METAL       167    167       Magnesium 1 (By similarity).
FT   METAL       167    167       Magnesium 2 (By similarity).
FT   METAL       169    169       Magnesium 1; via carbonyl oxygen (By
FT                                similarity).
FT   METAL       170    170       Magnesium 2 (By similarity).
FT   METAL       292    292       Magnesium 2 (By similarity).
SQ   SEQUENCE   355 AA;  39302 MW;  D3AFB892A79E837E CRC64;
     MSSSKMNGRS IRINRVPATI FAILLTIVLV YFLNFHQEER PAIYGKLRSD NPNRVNLRKM
     LIAAIQASQR GGLEVLDVAR SRQLKVRSKG QTDEGVNDPF TDADGRSHCV MKQGLQRIFP
     RVRIFSEEDK EHCKESHSYD LDPTVLHETA QVPDVSVNAQ DVTVWVDPLD ATKEFTEELY
     EYVTTMVCVA VAGRPVIGVI HSPFNGQTAW AWVGNSMSEY LAGLHPPHGQ ENELPIITVS
     RSHTAGAKDL ARGIFGEQVN LLTAAGAGYK VLQVVANNAT AYLHTSKIKK WDICAGDAIL
     HALGGTMTTL NDQLIRYGPD ESPVNTEGLL ATLEKHDKYM DQLVKYRTAH NGQLA
//