Reviewed, UniProtKB/Swiss-Prot Q29JH0 (IMPA3_DROPS)

Names and origin

Protein names

Recommended name:
    Putative inositol monophosphatase 3
    EC=3.1.3.25
Alternative name(s):
    Inositol-1(or 4)-monophosphatase 3
      Short name=IMPase 3
      Short name=IMP 3
    Myo-inositol monophosphatase A3

Gene names

ORF Names:

GA13929

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly) [Complete proteome]

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the inositol monophosphatase family.
Sequence caution	The sequence EAL32331.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylinositol biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB signal transduction Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	inositol-1(or 4)-monophosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Putative inositol monophosphatase 3		PRO_0000289047
Regions
	Transmembrane	16 – 36	21	Potential
Sites
	Metal binding	127	1	Magnesium 1 By similarity
	Metal binding	167	1	Magnesium 1 By similarity
	Metal binding	167	1	Magnesium 2 By similarity
	Metal binding	169	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	170	1	Magnesium 2 By similarity
	Metal binding	292	1	Magnesium 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29JH0-1 [UniParc]. Last modified May 29, 2007. Version 2. Checksum: D3AFB892A79E837E	FASTA	355	39,302
	10 20 30 40 50 60 MSSSKMNGRS IRINRVPATI FAILLTIVLV YFLNFHQEER PAIYGKLRSD NPNRVNLRKM 70 80 90 100 110 120 LIAAIQASQR GGLEVLDVAR SRQLKVRSKG QTDEGVNDPF TDADGRSHCV MKQGLQRIFP 130 140 150 160 170 180 RVRIFSEEDK EHCKESHSYD LDPTVLHETA QVPDVSVNAQ DVTVWVDPLD ATKEFTEELY 190 200 210 220 230 240 EYVTTMVCVA VAGRPVIGVI HSPFNGQTAW AWVGNSMSEY LAGLHPPHGQ ENELPIITVS 250 260 270 280 290 300 RSHTAGAKDL ARGIFGEQVN LLTAAGAGYK VLQVVANNAT AYLHTSKIKK WDICAGDAIL 310 320 330 340 350 HALGGTMTTL NDQLIRYGPD ESPVNTEGLL ATLEKHDKYM DQLVKYRTAH NGQLA

References

[1]

"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed: 15632085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH379063 Genomic DNA. Translation: EAL32331.2. Sequence problems.
RefSeq	XP_001355274.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4815471.
KEGG	dpo:Dpse_GA13929.
Organism-specific databases
FlyBase	FBgn0073961. Dpse\GA13929.
Enzyme and pathway databases
BRENDA	3.1.3.25. 190795.
Family and domain databases
InterPro	IPR000760. Inositol_P. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00378. INOSPHPHTASE.
PROSITE	PS00629. IMP_1. False negative. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IMPA3_DROPS

Accession

Primary (citable) accession number: Q29JH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	February 10, 2009
This is version 21 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project