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Q29IL2

- POMT2_DROPS

UniProt

Q29IL2 - POMT2_DROPS

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Protein

Protein O-mannosyl-transferase 2

Gene

tw

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.By similarity

Catalytic activityi

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.Curated

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid glycosylation Source: UniProtKB
  2. muscle organ development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-mannosyl-transferase 2 (EC:2.4.1.109)
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 2
Protein twisted
Gene namesi
Name:twBy similarity
ORF Names:GA11548
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0071599. Dpse\GA11548.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Protein O-mannosyl-transferase 2PRO_0000307927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi735 – 7351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with Rt/POMT1.By similarity

Protein-protein interaction databases

STRINGi7237.FBpp0273533.

Structurei

3D structure databases

ProteinModelPortaliQ29IL2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence AnalysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Transmembranei572 – 59221HelicalSequence AnalysisAdd
BLAST
Transmembranei645 – 66521HelicalSequence AnalysisAdd
BLAST
Transmembranei669 – 68921HelicalSequence AnalysisAdd
BLAST
Transmembranei703 – 72321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 37257MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini382 – 43857MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini443 – 49957MIR 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Sequence Analysis
Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1928.
InParanoidiQ29IL2.
KOiK00728.
OMAiWLCISRF.
OrthoDBiEOG79KPDP.
PhylomeDBiQ29IL2.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29IL2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASVVKTPK CPRRGSAKEQ QSKASPKSNN ESNNWHWWIL LASVFLITFA
60 70 80 90 100
TRFYKVTEPD HICWDETHFG KMGSWYINRT FFFDVHPPLG KMLIGLSGYL
110 120 130 140 150
TGYNGTFPFE KPGDKYNETA YQGMRYFCTT LGALIMPMGF DTVYDLTRSH
160 170 180 190 200
EAALLSAAYL IFDVGLLTLN QYILLDPILL FFMMGSVWGM VKISKATASG
210 220 230 240 250
GSYSVRWWFW LFLTGTMLSC TISVKFVGLF VVLLVGLHTA TELWLILGDL
260 270 280 290 300
GQPIVETLKQ IACRAIALIL WPILLYTLFF YIHLSVLNRS GNGDGFYSSA
310 320 330 340 350
FQSRLIGNSL YNASMPRDVA YGSVVTIKNH KTGGGYLHSH FHLYPKGSGA
360 370 380 390 400
RQQQITTYTH KDDNNKWVIK PHNKQRLPKD KLQLLRHGDL VRLEHLVTKR
410 420 430 440 450
NLHSHSEPAP MTKKHLQVTG YGESGVGDAN DVWRVLIVGG KVNETVHTVT
460 470 480 490 500
SRLMLIHYLQ NCALTSSGKQ LPKWGFEQQE VSCNLNVRDK YAHWNVEDNE
510 520 530 540 550
HKLLPSVSFS VYAPGFFARF LESHAVMLQG NAGLKPKEGE VTSRPWQWPI
560 570 580 590 600
NYRGQFFSGS SYRIYLLGNP VIWWSNLVFL ALFVAVFLGN AILEQRRAGQ
610 620 630 640 650
ARALVRSQAD SEDSEPSTTD VPLCTCCPEE QQLLSRPREE HRDPLGAAAW
660 670 680 690 700
LFVGWLLHYL PFWAMGRVLY FHHYFPALIF NSLLTGVMFH HIIQSLPRWI
710 720 730 740
QHVLLGGLLS LIVYSFALFS PLAYGMSGPL ANEPNSTMHS LKWLSTWEF
Length:749
Mass (Da):84,957
Last modified:April 4, 2006 - v1
Checksum:i4235318C19C91334
GO

Sequence cautioni

The sequence EAL32641.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379063 Genomic DNA. Translation: EAL32641.1. Sequence problems.
RefSeqiXP_001355582.1. XM_001355546.2.

Genome annotation databases

EnsemblMetazoaiFBtr0275095; FBpp0273533; FBgn0071599.
GeneIDi4815847.
KEGGidpo:Dpse_GA11548.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379063 Genomic DNA. Translation: EAL32641.1 . Sequence problems.
RefSeqi XP_001355582.1. XM_001355546.2.

3D structure databases

ProteinModelPortali Q29IL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0273533.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0275095 ; FBpp0273533 ; FBgn0071599 .
GeneIDi 4815847.
KEGGi dpo:Dpse_GA11548.

Organism-specific databases

FlyBasei FBgn0071599. Dpse\GA11548.

Phylogenomic databases

eggNOGi COG1928.
InParanoidi Q29IL2.
KOi K00728.
OMAi WLCISRF.
OrthoDBi EOG79KPDP.
PhylomeDBi Q29IL2.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiPOMT2_DROPS
AccessioniPrimary (citable) accession number: Q29IL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 4, 2006
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3