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Protein

Protein O-mannosyl-transferase 2

Gene

tw

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.By similarity

Catalytic activityi

Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.Curated

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-mannosyl-transferase 2 (EC:2.4.1.109)
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 2
Protein twisted
Gene namesi
Name:twBy similarity
ORF Names:GA11548
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0071599. Dpse\GA11548.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei572 – 592HelicalSequence analysisAdd BLAST21
Transmembranei645 – 665HelicalSequence analysisAdd BLAST21
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21
Transmembranei703 – 723HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079271 – 749Protein O-mannosyl-transferase 2Add BLAST749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Glycosylationi443N-linked (GlcNAc...)Sequence analysis1
Glycosylationi735N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with Rt/POMT1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ29IL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 372MIR 1PROSITE-ProRule annotationAdd BLAST57
Domaini382 – 438MIR 2PROSITE-ProRule annotationAdd BLAST57
Domaini443 – 499MIR 3PROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Sequence analysis
Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ29IL2.
KOiK00728.
OMAiTIEDLWE.
PhylomeDBiQ29IL2.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR003342. Glyco_trans_39/83.
IPR016093. MIR_motif.
IPR032421. PMT_4TMC.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 2 hits.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
PF16192. PMT_4TMC. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29IL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVVKTPK CPRRGSAKEQ QSKASPKSNN ESNNWHWWIL LASVFLITFA
60 70 80 90 100
TRFYKVTEPD HICWDETHFG KMGSWYINRT FFFDVHPPLG KMLIGLSGYL
110 120 130 140 150
TGYNGTFPFE KPGDKYNETA YQGMRYFCTT LGALIMPMGF DTVYDLTRSH
160 170 180 190 200
EAALLSAAYL IFDVGLLTLN QYILLDPILL FFMMGSVWGM VKISKATASG
210 220 230 240 250
GSYSVRWWFW LFLTGTMLSC TISVKFVGLF VVLLVGLHTA TELWLILGDL
260 270 280 290 300
GQPIVETLKQ IACRAIALIL WPILLYTLFF YIHLSVLNRS GNGDGFYSSA
310 320 330 340 350
FQSRLIGNSL YNASMPRDVA YGSVVTIKNH KTGGGYLHSH FHLYPKGSGA
360 370 380 390 400
RQQQITTYTH KDDNNKWVIK PHNKQRLPKD KLQLLRHGDL VRLEHLVTKR
410 420 430 440 450
NLHSHSEPAP MTKKHLQVTG YGESGVGDAN DVWRVLIVGG KVNETVHTVT
460 470 480 490 500
SRLMLIHYLQ NCALTSSGKQ LPKWGFEQQE VSCNLNVRDK YAHWNVEDNE
510 520 530 540 550
HKLLPSVSFS VYAPGFFARF LESHAVMLQG NAGLKPKEGE VTSRPWQWPI
560 570 580 590 600
NYRGQFFSGS SYRIYLLGNP VIWWSNLVFL ALFVAVFLGN AILEQRRAGQ
610 620 630 640 650
ARALVRSQAD SEDSEPSTTD VPLCTCCPEE QQLLSRPREE HRDPLGAAAW
660 670 680 690 700
LFVGWLLHYL PFWAMGRVLY FHHYFPALIF NSLLTGVMFH HIIQSLPRWI
710 720 730 740
QHVLLGGLLS LIVYSFALFS PLAYGMSGPL ANEPNSTMHS LKWLSTWEF
Length:749
Mass (Da):84,957
Last modified:April 4, 2006 - v1
Checksum:i4235318C19C91334
GO

Sequence cautioni

The sequence EAL32641 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379063 Genomic DNA. Translation: EAL32641.1. Sequence problems.
RefSeqiXP_001355582.1. XM_001355546.3.

Genome annotation databases

EnsemblMetazoaiFBtr0275095; FBpp0273533; FBgn0071599.
GeneIDi4815847.
KEGGidpo:Dpse_GA11548.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379063 Genomic DNA. Translation: EAL32641.1. Sequence problems.
RefSeqiXP_001355582.1. XM_001355546.3.

3D structure databases

ProteinModelPortaliQ29IL2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0275095; FBpp0273533; FBgn0071599.
GeneIDi4815847.
KEGGidpo:Dpse_GA11548.

Organism-specific databases

FlyBaseiFBgn0071599. Dpse\GA11548.

Phylogenomic databases

InParanoidiQ29IL2.
KOiK00728.
OMAiTIEDLWE.
PhylomeDBiQ29IL2.

Enzyme and pathway databases

UniPathwayiUPA00378.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR003342. Glyco_trans_39/83.
IPR016093. MIR_motif.
IPR032421. PMT_4TMC.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 2 hits.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
PF16192. PMT_4TMC. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOMT2_DROPS
AccessioniPrimary (citable) accession number: Q29IL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 4, 2006
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.