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Q29IL2

- POMT2_DROPS

UniProt

Q29IL2 - POMT2_DROPS

Protein

Protein O-mannosyl-transferase 2

Gene

tw

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.By similarity

    Catalytic activityi

    Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.Curated

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid glycosylation Source: UniProtKB
    2. muscle organ development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein O-mannosyl-transferase 2 (EC:2.4.1.109)
    Alternative name(s):
    Dolichyl-phosphate-mannose--protein mannosyltransferase 2
    Protein twisted
    Gene namesi
    Name:twBy similarity
    ORF Names:GA11548
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0071599. Dpse\GA11548.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 749749Protein O-mannosyl-transferase 2PRO_0000307927Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi735 – 7351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with Rt/POMT1.By similarity

    Protein-protein interaction databases

    STRINGi7237.FBpp0273533.

    Structurei

    3D structure databases

    ProteinModelPortaliQ29IL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei572 – 59221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei645 – 66521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei669 – 68921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei703 – 72321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini316 – 37257MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini382 – 43857MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini443 – 49957MIR 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyltransferase 39 family.Sequence Analysis
    Contains 3 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1928.
    InParanoidiQ29IL2.
    KOiK00728.
    OMAiWLCISRF.
    OrthoDBiEOG79KPDP.
    PhylomeDBiQ29IL2.

    Family and domain databases

    InterProiIPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    [Graphical view]
    PANTHERiPTHR10050. PTHR10050. 1 hit.
    PfamiPF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view]
    SMARTiSM00472. MIR. 3 hits.
    [Graphical view]
    SUPFAMiSSF82109. SSF82109. 1 hit.
    PROSITEiPS50919. MIR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29IL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASVVKTPK CPRRGSAKEQ QSKASPKSNN ESNNWHWWIL LASVFLITFA    50
    TRFYKVTEPD HICWDETHFG KMGSWYINRT FFFDVHPPLG KMLIGLSGYL 100
    TGYNGTFPFE KPGDKYNETA YQGMRYFCTT LGALIMPMGF DTVYDLTRSH 150
    EAALLSAAYL IFDVGLLTLN QYILLDPILL FFMMGSVWGM VKISKATASG 200
    GSYSVRWWFW LFLTGTMLSC TISVKFVGLF VVLLVGLHTA TELWLILGDL 250
    GQPIVETLKQ IACRAIALIL WPILLYTLFF YIHLSVLNRS GNGDGFYSSA 300
    FQSRLIGNSL YNASMPRDVA YGSVVTIKNH KTGGGYLHSH FHLYPKGSGA 350
    RQQQITTYTH KDDNNKWVIK PHNKQRLPKD KLQLLRHGDL VRLEHLVTKR 400
    NLHSHSEPAP MTKKHLQVTG YGESGVGDAN DVWRVLIVGG KVNETVHTVT 450
    SRLMLIHYLQ NCALTSSGKQ LPKWGFEQQE VSCNLNVRDK YAHWNVEDNE 500
    HKLLPSVSFS VYAPGFFARF LESHAVMLQG NAGLKPKEGE VTSRPWQWPI 550
    NYRGQFFSGS SYRIYLLGNP VIWWSNLVFL ALFVAVFLGN AILEQRRAGQ 600
    ARALVRSQAD SEDSEPSTTD VPLCTCCPEE QQLLSRPREE HRDPLGAAAW 650
    LFVGWLLHYL PFWAMGRVLY FHHYFPALIF NSLLTGVMFH HIIQSLPRWI 700
    QHVLLGGLLS LIVYSFALFS PLAYGMSGPL ANEPNSTMHS LKWLSTWEF 749
    Length:749
    Mass (Da):84,957
    Last modified:April 4, 2006 - v1
    Checksum:i4235318C19C91334
    GO

    Sequence cautioni

    The sequence EAL32641.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379063 Genomic DNA. Translation: EAL32641.1. Sequence problems.
    RefSeqiXP_001355582.1. XM_001355546.2.

    Genome annotation databases

    EnsemblMetazoaiFBtr0275095; FBpp0273533; FBgn0071599.
    GeneIDi4815847.
    KEGGidpo:Dpse_GA11548.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379063 Genomic DNA. Translation: EAL32641.1 . Sequence problems.
    RefSeqi XP_001355582.1. XM_001355546.2.

    3D structure databases

    ProteinModelPortali Q29IL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0273533.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0275095 ; FBpp0273533 ; FBgn0071599 .
    GeneIDi 4815847.
    KEGGi dpo:Dpse_GA11548.

    Organism-specific databases

    FlyBasei FBgn0071599. Dpse\GA11548.

    Phylogenomic databases

    eggNOGi COG1928.
    InParanoidi Q29IL2.
    KOi K00728.
    OMAi WLCISRF.
    OrthoDBi EOG79KPDP.
    PhylomeDBi Q29IL2.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    [Graphical view ]
    PANTHERi PTHR10050. PTHR10050. 1 hit.
    Pfami PF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view ]
    SMARTi SM00472. MIR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF82109. SSF82109. 1 hit.
    PROSITEi PS50919. MIR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiPOMT2_DROPS
    AccessioniPrimary (citable) accession number: Q29IL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3