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Q29IL2 (POMT2_DROPS) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein O-mannosyl-transferase 2

EC=2.4.1.109
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 2
Protein twisted
Gene names
Name:tw
ORF Names:GA11548
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]
Taxonomic identifier46245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length749 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development By similarity.

Catalytic activity

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

Pathway

Protein modification; protein glycosylation.

Subunit structure

Interacts with Rt/POMT1 By similarity. UniProtKB Q9W5D4

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity UniProtKB Q9W5D4.

Sequence similarities

Belongs to the glycosyltransferase 39 family.

Contains 3 MIR domains.

Sequence caution

The sequence EAL32641.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 749749Protein O-mannosyl-transferase 2
PRO_0000307927

Regions

Transmembrane34 – 5421Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane266 – 28621Helical; Potential
Transmembrane572 – 59221Helical; Potential
Transmembrane645 – 66521Helical; Potential
Transmembrane669 – 68921Helical; Potential
Transmembrane703 – 72321Helical; Potential
Domain316 – 37257MIR 1
Domain382 – 43857MIR 2
Domain443 – 49957MIR 3

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation2881N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation4431N-linked (GlcNAc...) Potential
Glycosylation7351N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q29IL2 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: 4235318C19C91334

FASTA74984,957
        10         20         30         40         50         60 
MAASVVKTPK CPRRGSAKEQ QSKASPKSNN ESNNWHWWIL LASVFLITFA TRFYKVTEPD 

        70         80         90        100        110        120 
HICWDETHFG KMGSWYINRT FFFDVHPPLG KMLIGLSGYL TGYNGTFPFE KPGDKYNETA 

       130        140        150        160        170        180 
YQGMRYFCTT LGALIMPMGF DTVYDLTRSH EAALLSAAYL IFDVGLLTLN QYILLDPILL 

       190        200        210        220        230        240 
FFMMGSVWGM VKISKATASG GSYSVRWWFW LFLTGTMLSC TISVKFVGLF VVLLVGLHTA 

       250        260        270        280        290        300 
TELWLILGDL GQPIVETLKQ IACRAIALIL WPILLYTLFF YIHLSVLNRS GNGDGFYSSA 

       310        320        330        340        350        360 
FQSRLIGNSL YNASMPRDVA YGSVVTIKNH KTGGGYLHSH FHLYPKGSGA RQQQITTYTH 

       370        380        390        400        410        420 
KDDNNKWVIK PHNKQRLPKD KLQLLRHGDL VRLEHLVTKR NLHSHSEPAP MTKKHLQVTG 

       430        440        450        460        470        480 
YGESGVGDAN DVWRVLIVGG KVNETVHTVT SRLMLIHYLQ NCALTSSGKQ LPKWGFEQQE 

       490        500        510        520        530        540 
VSCNLNVRDK YAHWNVEDNE HKLLPSVSFS VYAPGFFARF LESHAVMLQG NAGLKPKEGE 

       550        560        570        580        590        600 
VTSRPWQWPI NYRGQFFSGS SYRIYLLGNP VIWWSNLVFL ALFVAVFLGN AILEQRRAGQ 

       610        620        630        640        650        660 
ARALVRSQAD SEDSEPSTTD VPLCTCCPEE QQLLSRPREE HRDPLGAAAW LFVGWLLHYL 

       670        680        690        700        710        720 
PFWAMGRVLY FHHYFPALIF NSLLTGVMFH HIIQSLPRWI QHVLLGGLLS LIVYSFALFS 

       730        740 
PLAYGMSGPL ANEPNSTMHS LKWLSTWEF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH379063 Genomic DNA. Translation: EAL32641.1. Sequence problems.
RefSeqXP_001355582.1. XM_001355546.2.

3D structure databases

ProteinModelPortalQ29IL2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7237.FBpp0273533.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0275095; FBpp0273533; FBgn0071599.
GeneID4815847.
KEGGdpo:Dpse_GA11548.

Organism-specific databases

FlyBaseFBgn0071599. Dpse\GA11548.

Phylogenomic databases

eggNOGCOG1928.
InParanoidQ29IL2.
KOK00728.
OMAWLCISRF.
OrthoDBEOG79KPDP.
PhylomeDBQ29IL2.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERPTHR10050. PTHR10050. 1 hit.
PfamPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMSSF82109. SSF82109. 1 hit.
PROSITEPS50919. MIR. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePOMT2_DROPS
AccessionPrimary (citable) accession number: Q29IL2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase