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Q29IL2

- POMT2_DROPS

UniProt

Q29IL2 - POMT2_DROPS

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Protein
Protein O-mannosyl-transferase 2
Gene
tw, GA11548
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development By similarity.

Catalytic activityi

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid glycosylation Source: UniProtKB
  2. muscle organ development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-mannosyl-transferase 2 (EC:2.4.1.109)
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 2
Protein twisted
Gene namesi
Name:tw
ORF Names:GA11548
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0071599. Dpse\GA11548.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421Helical; Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Reviewed prediction
Add
BLAST
Transmembranei173 – 19321Helical; Reviewed prediction
Add
BLAST
Transmembranei204 – 22421Helical; Reviewed prediction
Add
BLAST
Transmembranei226 – 24621Helical; Reviewed prediction
Add
BLAST
Transmembranei266 – 28621Helical; Reviewed prediction
Add
BLAST
Transmembranei572 – 59221Helical; Reviewed prediction
Add
BLAST
Transmembranei645 – 66521Helical; Reviewed prediction
Add
BLAST
Transmembranei669 – 68921Helical; Reviewed prediction
Add
BLAST
Transmembranei703 – 72321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Protein O-mannosyl-transferase 2
PRO_0000307927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi735 – 7351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with Rt/POMT1 By similarity.By similarity

Protein-protein interaction databases

STRINGi7237.FBpp0273533.

Structurei

3D structure databases

ProteinModelPortaliQ29IL2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 37257MIR 1
Add
BLAST
Domaini382 – 43857MIR 2
Add
BLAST
Domaini443 – 49957MIR 3
Add
BLAST

Sequence similaritiesi

Contains 3 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1928.
InParanoidiQ29IL2.
KOiK00728.
OMAiWLCISRF.
OrthoDBiEOG79KPDP.
PhylomeDBiQ29IL2.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29IL2-1 [UniParc]FASTAAdd to Basket

« Hide

MAASVVKTPK CPRRGSAKEQ QSKASPKSNN ESNNWHWWIL LASVFLITFA    50
TRFYKVTEPD HICWDETHFG KMGSWYINRT FFFDVHPPLG KMLIGLSGYL 100
TGYNGTFPFE KPGDKYNETA YQGMRYFCTT LGALIMPMGF DTVYDLTRSH 150
EAALLSAAYL IFDVGLLTLN QYILLDPILL FFMMGSVWGM VKISKATASG 200
GSYSVRWWFW LFLTGTMLSC TISVKFVGLF VVLLVGLHTA TELWLILGDL 250
GQPIVETLKQ IACRAIALIL WPILLYTLFF YIHLSVLNRS GNGDGFYSSA 300
FQSRLIGNSL YNASMPRDVA YGSVVTIKNH KTGGGYLHSH FHLYPKGSGA 350
RQQQITTYTH KDDNNKWVIK PHNKQRLPKD KLQLLRHGDL VRLEHLVTKR 400
NLHSHSEPAP MTKKHLQVTG YGESGVGDAN DVWRVLIVGG KVNETVHTVT 450
SRLMLIHYLQ NCALTSSGKQ LPKWGFEQQE VSCNLNVRDK YAHWNVEDNE 500
HKLLPSVSFS VYAPGFFARF LESHAVMLQG NAGLKPKEGE VTSRPWQWPI 550
NYRGQFFSGS SYRIYLLGNP VIWWSNLVFL ALFVAVFLGN AILEQRRAGQ 600
ARALVRSQAD SEDSEPSTTD VPLCTCCPEE QQLLSRPREE HRDPLGAAAW 650
LFVGWLLHYL PFWAMGRVLY FHHYFPALIF NSLLTGVMFH HIIQSLPRWI 700
QHVLLGGLLS LIVYSFALFS PLAYGMSGPL ANEPNSTMHS LKWLSTWEF 749
Length:749
Mass (Da):84,957
Last modified:April 4, 2006 - v1
Checksum:i4235318C19C91334
GO

Sequence cautioni

The sequence EAL32641.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379063 Genomic DNA. Translation: EAL32641.1. Sequence problems.
RefSeqiXP_001355582.1. XM_001355546.2.

Genome annotation databases

EnsemblMetazoaiFBtr0275095; FBpp0273533; FBgn0071599.
GeneIDi4815847.
KEGGidpo:Dpse_GA11548.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379063 Genomic DNA. Translation: EAL32641.1 . Sequence problems.
RefSeqi XP_001355582.1. XM_001355546.2.

3D structure databases

ProteinModelPortali Q29IL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0273533.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0275095 ; FBpp0273533 ; FBgn0071599 .
GeneIDi 4815847.
KEGGi dpo:Dpse_GA11548.

Organism-specific databases

FlyBasei FBgn0071599. Dpse\GA11548.

Phylogenomic databases

eggNOGi COG1928.
InParanoidi Q29IL2.
KOi K00728.
OMAi WLCISRF.
OrthoDBi EOG79KPDP.
PhylomeDBi Q29IL2.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiPOMT2_DROPS
AccessioniPrimary (citable) accession number: Q29IL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi