Reviewed, UniProtKB/Swiss-Prot Q29I93 (ASGL1_DROPS)

Names and origin

Protein names

Recommended name:
    Probable L-asparaginase GA20639
    EC=3.5.1.1
Alternative name(s):
    L-asparagine amidohydrolase GA20639

Gene names

ORF Names:

GA20639

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly) [Complete proteome]

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Acts in asparagine catabolism By similarity.
Catalytic activity	L-asparagine + H2O = L-aspartate + NH3.
Sequence similarities	Belongs to the Ntn-hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparagine catabolic process via L-aspartate Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Probable L-asparaginase GA20639		PRO_0000305211
Sites
	Active site	184	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q29I93-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: BA6B5E618AB35038	FASTA	325	34,399
	10 20 30 40 50 60 MPRPVLLIHG GAGDIPDSRI AGKFKGIKEA LRCAWGSLVP ASGAKGGALD AVETAVRSME 70 80 90 100 110 120 LDENFNAGYG SCLNTDGQVE MEASLMEGQD LRAGCVTLLR DVMHPITVAR RLMEKQRHTF 130 140 150 160 170 180 IGGEAAQELA LSTGSERLPA NALVTEGARF TLQQFKEQLT QGKDPFFART ELAAEQKTDP 190 200 210 220 230 240 SGETVGAVAM DHNGQIVVGT STGGITGKWP GRIGDTPILG SGTYADNARG GVSTTGHGET 250 260 270 280 290 300 IMRYNLAQRI LAAIEHKGMS AQAAADQECR EMTRRIGGTG GAIVVGHAGD LGISFTSQRM 310 320 AWGYIQDDTI FYGIEGQVVH QEPLS

References

[1]

"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed: 15632085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH379063 Genomic DNA. Translation: EAL32760.1.
RefSeq	XP_001355701.1.
3D structure databases
SMR	Q29I93. Positions 4-306.
ModBase	Search...
Genome annotation databases
GeneID	4815446.
KEGG	dpo:Dpse_GA20639.
Organism-specific databases
FlyBase	FBgn0080633. Dpse\GA20639.
Phylogenomic databases
InParanoid	Q29I93.
OMA	NKQVGRV.
OrthoDB	EOG9Z62VP.
PhylomeDB	Q29I93.
Enzyme and pathway databases
BRENDA	3.5.1.1. 190795.
Family and domain databases
InterPro	IPR000246. Peptidase_T2. [Graphical view]
PANTHER	PTHR10188. Peptidase_T2. 1 hit.
Pfam	PF01112. Asparaginase_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASGL1_DROPS

Accession

Primary (citable) accession number: Q29I93

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	April 4, 2006
Last modified:	January 19, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project