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Q29I35

- ARM_DROPS

UniProt

Q29I35 - ARM_DROPS

Protein

Armadillo segment polarity protein

Gene

arm

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity.By similarity

    GO - Molecular functioni

    1. cadherin binding Source: UniProtKB
    2. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. intracellular protein transport Source: InterPro
    3. neuroblast fate commitment Source: UniProtKB
    4. segment polarity determination Source: UniProtKB-KW
    5. vesicle-mediated transport Source: InterPro
    6. Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Segmentation polarity protein

    Keywords - Biological processi

    Cell adhesion, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Armadillo segment polarity protein
    Gene namesi
    Name:armBy similarity
    ORF Names:GA27602
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0248967. Dpse\GA27602.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
    Note: Inner surface of cell membrane and adherens junction.By similarity

    GO - Cellular componenti

    1. adherens junction Source: UniProtKB
    2. membrane coat Source: InterPro
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 832832Armadillo segment polarity proteinPRO_0000312834Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7237.FBpp0285007.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati149 – 18840ARM 1Add
    BLAST
    Repeati191 – 23141ARM 2Add
    BLAST
    Repeati233 – 27240ARM 3Add
    BLAST
    Repeati275 – 31440ARM 4Add
    BLAST
    Repeati359 – 39739ARM 5Add
    BLAST
    Repeati398 – 43740ARM 6Add
    BLAST
    Repeati440 – 48142ARM 7Add
    BLAST
    Repeati487 – 52741ARM 8Add
    BLAST
    Repeati597 – 63640ARM 9Add
    BLAST
    Repeati638 – 67740ARM 10Add
    BLAST

    Sequence similaritiesi

    Belongs to the beta-catenin family.Sequence Analysis
    Contains 10 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG297695.
    InParanoidiQ29I35.
    KOiK02105.
    OrthoDBiEOG7X9G6B.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF00514. Arm. 3 hits.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 12 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q29I35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYMPAQNRT MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LGDSGIHSGA    50
    VTQVPSLSGK EDEEMEGDPL MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ 100
    RVRAAMFPET LEEGIEIPST QFDPQQPTAV QRLSEPSQML KHAVVNLINY 150
    QDDAELATRA IPELIKLLND EDQVVVSQAA MMVHQLSKKE ASRHAIMNSP 200
    QMVAALVRAI SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK 250
    LLSSPVESVL FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK 300
    FLAIVTDCLQ ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR 350
    VLKVLSVCSS NKPAIVDAGG MQALAMHLGN MSPRLVQNCL WTLRNLSDAA 400
    TKVEGLEALL QSLVQVLGST DVNVVTCAAG ILSNLTCNNQ RNKATVCQVG 450
    GVDALVRTII NAGDREEITE PAVCALRHLT SRHVDSELAQ NAVRLNYGLS 500
    VIVKLLHPPS RWPLIKAVIG LIRNLALCPA NHAPLREHGA IHHLVRLLMR 550
    AFQDTERQRS SIATTGSQQP SAYADGVRME EIVEGTVGAL HILARESHNR 600
    ALIRQQSVIP IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT 650
    GPLTDLLHSR NEGVATYAAA VLFRMSEDKP QDYKKRLSIE LTNSLLREDN 700
    NIWANADLGM GPDLQVGSLQ GASALILLLY IFSISPYRLF AGYDTLPIDS 750
    MQGLEISSPV GGGGATGNSG GVNSASAGSG AVVPPSGAPT SPYSMDMDVG 800
    EIDAGALNFD LDAMPTPPND NNNLAAWYDT DC 832
    Length:832
    Mass (Da):90,293
    Last modified:January 20, 2009 - v2
    Checksum:i52205E16C85BE598
    GO

    Sequence cautioni

    The sequence EDY72488.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379064 Genomic DNA. Translation: EDY72488.1. Sequence problems.
    RefSeqiXP_002133861.1. XM_002133825.1.

    Genome annotation databases

    GeneIDi6901160.
    KEGGidpo:Dpse_GA27602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379064 Genomic DNA. Translation: EDY72488.1 . Sequence problems.
    RefSeqi XP_002133861.1. XM_002133825.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0285007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6901160.
    KEGGi dpo:Dpse_GA27602.

    Organism-specific databases

    FlyBasei FBgn0248967. Dpse\GA27602.

    Phylogenomic databases

    eggNOGi NOG297695.
    InParanoidi Q29I35.
    KOi K02105.
    OrthoDBi EOG7X9G6B.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF00514. Arm. 3 hits.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 12 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiARM_DROPS
    AccessioniPrimary (citable) accession number: Q29I35
    Secondary accession number(s): B5DLU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3