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Protein

Armadillo segment polarity protein

Gene

arm

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Segmentation polarity protein
Biological processCell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:armBy similarity
ORF Names:GA27602
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0248967. Dpse\GA27602.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128341 – 832Armadillo segment polarity proteinAdd BLAST832

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7237.FBpp0285007.

Structurei

3D structure databases

SMRiQ29I35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati149 – 188ARM 1Add BLAST40
Repeati191 – 231ARM 2Add BLAST41
Repeati233 – 272ARM 3Add BLAST40
Repeati275 – 314ARM 4Add BLAST40
Repeati359 – 397ARM 5Add BLAST39
Repeati398 – 437ARM 6Add BLAST40
Repeati440 – 481ARM 7Add BLAST42
Repeati487 – 527ARM 8Add BLAST41
Repeati597 – 636ARM 9Add BLAST40
Repeati638 – 677ARM 10Add BLAST40

Sequence similaritiesi

Belongs to the beta-catenin family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ29I35.
KOiK02105.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
PfamiView protein in Pfam
PF00514. Arm. 4 hits.
PRINTSiPR01869. BCATNINFAMLY.
SMARTiView protein in SMART
SM00185. ARM. 12 hits.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS50176. ARM_REPEAT. 9 hits.

Sequencei

Sequence statusi: Complete.

Q29I35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYMPAQNRT MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LGDSGIHSGA
60 70 80 90 100
VTQVPSLSGK EDEEMEGDPL MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ
110 120 130 140 150
RVRAAMFPET LEEGIEIPST QFDPQQPTAV QRLSEPSQML KHAVVNLINY
160 170 180 190 200
QDDAELATRA IPELIKLLND EDQVVVSQAA MMVHQLSKKE ASRHAIMNSP
210 220 230 240 250
QMVAALVRAI SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK
260 270 280 290 300
LLSSPVESVL FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK
310 320 330 340 350
FLAIVTDCLQ ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR
360 370 380 390 400
VLKVLSVCSS NKPAIVDAGG MQALAMHLGN MSPRLVQNCL WTLRNLSDAA
410 420 430 440 450
TKVEGLEALL QSLVQVLGST DVNVVTCAAG ILSNLTCNNQ RNKATVCQVG
460 470 480 490 500
GVDALVRTII NAGDREEITE PAVCALRHLT SRHVDSELAQ NAVRLNYGLS
510 520 530 540 550
VIVKLLHPPS RWPLIKAVIG LIRNLALCPA NHAPLREHGA IHHLVRLLMR
560 570 580 590 600
AFQDTERQRS SIATTGSQQP SAYADGVRME EIVEGTVGAL HILARESHNR
610 620 630 640 650
ALIRQQSVIP IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT
660 670 680 690 700
GPLTDLLHSR NEGVATYAAA VLFRMSEDKP QDYKKRLSIE LTNSLLREDN
710 720 730 740 750
NIWANADLGM GPDLQVGSLQ GASALILLLY IFSISPYRLF AGYDTLPIDS
760 770 780 790 800
MQGLEISSPV GGGGATGNSG GVNSASAGSG AVVPPSGAPT SPYSMDMDVG
810 820 830
EIDAGALNFD LDAMPTPPND NNNLAAWYDT DC
Length:832
Mass (Da):90,293
Last modified:January 20, 2009 - v2
Checksum:i52205E16C85BE598
GO

Sequence cautioni

The sequence EDY72488 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379064 Genomic DNA. Translation: EDY72488.1. Sequence problems.
RefSeqiXP_002133861.1. XM_002133825.2.
XP_015041425.1. XM_015185939.1.
XP_015041426.1. XM_015185940.1.

Genome annotation databases

EnsemblMetazoaiFBtr0286569; FBpp0285007; FBgn0248967.
FBtr0286573; FBpp0285011; FBgn0248971.
GeneIDi6901160.
KEGGidpo:Dpse_GA27602.

Similar proteinsi

Entry informationi

Entry nameiARM_DROPS
AccessioniPrimary (citable) accession number: Q29I35
Secondary accession number(s): B5DLU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 20, 2009
Last modified: August 30, 2017
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families