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Q29I35

- ARM_DROPS

UniProt

Q29I35 - ARM_DROPS

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Protein

Armadillo segment polarity protein

Gene

arm

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (By similarity).By similarity

GO - Molecular functioni

  1. cadherin binding Source: UniProtKB
  2. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. intracellular protein transport Source: InterPro
  3. neuroblast fate commitment Source: UniProtKB
  4. segment polarity determination Source: UniProtKB-KW
  5. vesicle-mediated transport Source: InterPro
  6. Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:armBy similarity
ORF Names:GA27602
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0248967. Dpse\GA27602.

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
Note: Inner surface of cell membrane and adherens junction.By similarity

GO - Cellular componenti

  1. adherens junction Source: UniProtKB
  2. membrane coat Source: InterPro
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Armadillo segment polarity proteinPRO_0000312834Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0285007.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati149 – 18840ARM 1Add
BLAST
Repeati191 – 23141ARM 2Add
BLAST
Repeati233 – 27240ARM 3Add
BLAST
Repeati275 – 31440ARM 4Add
BLAST
Repeati359 – 39739ARM 5Add
BLAST
Repeati398 – 43740ARM 6Add
BLAST
Repeati440 – 48142ARM 7Add
BLAST
Repeati487 – 52741ARM 8Add
BLAST
Repeati597 – 63640ARM 9Add
BLAST
Repeati638 – 67740ARM 10Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Sequence Analysis
Contains 10 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
InParanoidiQ29I35.
KOiK02105.
OrthoDBiEOG7X9G6B.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q29I35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYMPAQNRT MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LGDSGIHSGA
60 70 80 90 100
VTQVPSLSGK EDEEMEGDPL MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ
110 120 130 140 150
RVRAAMFPET LEEGIEIPST QFDPQQPTAV QRLSEPSQML KHAVVNLINY
160 170 180 190 200
QDDAELATRA IPELIKLLND EDQVVVSQAA MMVHQLSKKE ASRHAIMNSP
210 220 230 240 250
QMVAALVRAI SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK
260 270 280 290 300
LLSSPVESVL FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK
310 320 330 340 350
FLAIVTDCLQ ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR
360 370 380 390 400
VLKVLSVCSS NKPAIVDAGG MQALAMHLGN MSPRLVQNCL WTLRNLSDAA
410 420 430 440 450
TKVEGLEALL QSLVQVLGST DVNVVTCAAG ILSNLTCNNQ RNKATVCQVG
460 470 480 490 500
GVDALVRTII NAGDREEITE PAVCALRHLT SRHVDSELAQ NAVRLNYGLS
510 520 530 540 550
VIVKLLHPPS RWPLIKAVIG LIRNLALCPA NHAPLREHGA IHHLVRLLMR
560 570 580 590 600
AFQDTERQRS SIATTGSQQP SAYADGVRME EIVEGTVGAL HILARESHNR
610 620 630 640 650
ALIRQQSVIP IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT
660 670 680 690 700
GPLTDLLHSR NEGVATYAAA VLFRMSEDKP QDYKKRLSIE LTNSLLREDN
710 720 730 740 750
NIWANADLGM GPDLQVGSLQ GASALILLLY IFSISPYRLF AGYDTLPIDS
760 770 780 790 800
MQGLEISSPV GGGGATGNSG GVNSASAGSG AVVPPSGAPT SPYSMDMDVG
810 820 830
EIDAGALNFD LDAMPTPPND NNNLAAWYDT DC
Length:832
Mass (Da):90,293
Last modified:January 20, 2009 - v2
Checksum:i52205E16C85BE598
GO

Sequence cautioni

The sequence EDY72488.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379064 Genomic DNA. Translation: EDY72488.1. Sequence problems.
RefSeqiXP_002133861.1. XM_002133825.1.

Genome annotation databases

GeneIDi6901160.
KEGGidpo:Dpse_GA27602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379064 Genomic DNA. Translation: EDY72488.1 . Sequence problems.
RefSeqi XP_002133861.1. XM_002133825.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0285007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6901160.
KEGGi dpo:Dpse_GA27602.

Organism-specific databases

FlyBasei FBgn0248967. Dpse\GA27602.

Phylogenomic databases

eggNOGi NOG297695.
InParanoidi Q29I35.
KOi K02105.
OrthoDBi EOG7X9G6B.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiARM_DROPS
AccessioniPrimary (citable) accession number: Q29I35
Secondary accession number(s): B5DLU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 20, 2009
Last modified: October 29, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3