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Protein

Cdc42 homolog

Gene

Cdc42

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 homolog
Gene namesi
Name:Cdc42By similarity
ORF Names:GA11680
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0071730 Dpse\GA11680

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128211 – 188Cdc42 homologBy similarityAdd BLAST188
PropeptideiPRO_0000312822189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Expressioni

Gene expression databases

BgeeiFBgn0071730

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7237.FBpp0285703

Structurei

3D structure databases

ProteinModelPortaliQ29HY3
SMRiQ29HY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.Sequence analysis

Phylogenomic databases

InParanoidiQ29HY3
KOiK04393
OMAiMQTLKCV
PhylomeDBiQ29HY3

Family and domain databases

CDDicd01874 Cdc42, 1 hit
InterProiView protein in InterPro
IPR037874 Cdc42
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q29HY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP
60 70 80 90 100
YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE
110 120 130 140 150
ITHHCQKTPF LLVGTQIDLR DETSTLEKLA KNKQKPITME QGEKLAKELK
160 170 180 190
AVKYVECSAL TQKGLKNVFD EAILAALEPP EPTKKRKCKF L
Length:191
Mass (Da):21,390
Last modified:April 4, 2006 - v1
Checksum:i944B6574B83D00F6
GO

Sequence cautioni

The sequence EAL31624 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379064 Genomic DNA Translation: EAL31624.1 Sequence problems.
RefSeqiXP_001354570.1, XM_001354534.3
XP_015041468.1, XM_015185982.1

Genome annotation databases

EnsemblMetazoaiFBtr0287265; FBpp0285703; FBgn0071730
FBtr0367625; FBpp0330542; FBgn0071730
GeneIDi4814629
KEGGidpo:Dpse_GA11680

Similar proteinsi

Entry informationi

Entry nameiCDC42_DROPS
AccessioniPrimary (citable) accession number: Q29HY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 4, 2006
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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